公开(公告)号：US20100135856A1

公开(公告)日：2010-06-03

申请号：US12482223

申请日：2009-06-10

申请人： Hyeon-Bong PYO ,  Moon-Youn Jung ,  Seon-Hee Park

发明人： Hyeon-Bong PYO ,  Moon-Youn Jung ,  Seon-Hee Park

IPC分类号： G01N33/543 ,  B32B5/00 ,  G01N33/544 ,  G01N33/551 ,  G01N33/552 ,  G01N33/553

CPC分类号： G01N33/54346 ,  B82Y15/00 ,  G01N2610/00 ,  Y10T428/2991

摘要： Provided are a nanoparticle for detecting biomaterials and a biosensor by using the nanoparticle. The nanoparticle includes a metal nanostructure around which an electric field is induced by localized surface plasmon resonance when light is irradiated onto a surface of the metal nanostructure, a spacer covering the surface of the metal nanostructure, and capture molecules specifically reacting with fluorophore-labeled target molecules, and immobilized on a surface of the spacer.

摘要翻译： 提供了通过使用纳米颗粒检测生物材料的纳米颗粒和生物传感器。 纳米颗粒包括金属纳米结构，当光照射到金属纳米结构的表面上时，通过局部表面等离子体共振诱发电场，覆盖金属纳米结构表面的间隔区，并捕获与荧光团标记的靶特异性反应的分子 分子，并固定在间隔物的表面上。

公开(公告)号：US20120162643A1

公开(公告)日：2012-06-28

申请号：US13289396

申请日：2011-11-04

申请人： Hyeon-Bong PYO ,  Moon Youn JUNG

发明人： Hyeon-Bong PYO ,  Moon Youn JUNG

IPC分类号： G01J3/28 ,  G01N15/02

CPC分类号： G01N15/0205

摘要： A method for measuring the size of microparticles includes: measuring an extinction spectrum of a medium having microparticles dispersed therein; and calculating average size of the microparticles based on the measured extinction spectrum and the Mie scattering theory.

摘要翻译： 测定微粒尺寸的方法包括：测定其中分散有微粒的介质的消光谱; 并基于测得的消光谱和米氏散射理论计算微粒的平均尺寸。

公开(公告)号：US20080135502A1

公开(公告)日：2008-06-12

申请号：US11929800

申请日：2007-10-30

申请人： Hyeon-Bong PYO ,  Kwang-Hyo CHUNG ,  Young-Jun KIM ,  Se-Ho PARK ,  Seon-Hee PARK ,  Won-Ick JANG ,  Dae-Sik LEE

发明人： Hyeon-Bong PYO ,  Kwang-Hyo CHUNG ,  Young-Jun KIM ,  Se-Ho PARK ,  Seon-Hee PARK ,  Won-Ick JANG ,  Dae-Sik LEE

IPC分类号： B01D21/28 ,  B01D21/00 ,  B01D21/34 ,  B01D21/26

CPC分类号： G01N33/491 ,  B01D21/0075 ,  B01D21/0087 ,  B01D21/265 ,  B01D2221/10 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0409 ,  B01L2400/0487 ,  B01L2400/086

摘要： Provided is a blood plasma separator for separating blood plasma and blood cells from whole blood without an additional complicated structure by passing the whole blood through a micro channel having a predetermined shape to make the whole blood flow turbulently and cause a velocity difference or deflection between flows of the blood plasma and the blood cells of the whole blood, and a blood plasma separation method thereof. The blood plasma separator includes: a body; a micro channel formed in the body to allow blood to pass therethrough; a separation member formed at the micro channel to make flow of blood cells or blood plasma turbulent to separate the blood cells from the blood plasma; an inlet connected to the micro channel and configured to introduce blood into the micro channel; and an outlet connected to the micro channel and configured to discharge blood from the micro channel.

摘要翻译： 提供一种血浆分离器，用于通过使全血通过具有预定形状的微通道而使血液和血细胞从全血中分离而没有额外的复杂结构，以使整个血流紊流，并引起流动之间的速度差或偏转 的血浆和全血的血细胞，以及血浆分离方法。 血浆分离器包括：身体; 形成在体内以允许血液通过的微通道; 在所述微通道处形成分离构件以使血细胞或血浆紊流以使血细胞与血浆分离; 入口，其连接到所述微通道并且被配置为将血液引入所述微通道中; 以及连接到微通道并被配置为从微通道排出血液的出口。

公开(公告)号：US20100159614A1

公开(公告)日：2010-06-24

申请号：US12484806

申请日：2009-06-15

申请人： Hyun-Woo SONG ,  Yo-Han CHOI ,  Hyeon-Bong PYO

发明人： Hyun-Woo SONG ,  Yo-Han CHOI ,  Hyeon-Bong PYO

IPC分类号： G01N33/566 ,  B32B15/04 ,  B32B27/28 ,  B32B15/08

CPC分类号： G01N33/553 ,  G01N33/54393 ,  Y10T428/31507 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31692

摘要： Provided is a biochip and an apparatus for detecting a biomaterial. The biochip includes a metal thin film on the surface of a substrate, restraining autofluorescence of the substrate, and a spacer on the metal thin film, having capture molecules immobilized on the surface of the spacer and specifically bound to target molecules. The spacer has a thickness controlled to enhance the strength of a fluorescence signal emitted from a fluorophore labeled with the target molecules and immobilized on the spacer by the specific binding between the capture molecule and the target molecule.

摘要翻译： 提供了一种生物芯片和用于检测生物材料的装置。 生物芯片包括在基板表面上的金属薄膜，抑制基板的自发荧光和金属薄膜上的间隔物，其中捕获分子固定在间隔物的表面上并且特异性地结合到靶分子上。 间隔物具有被控制的厚度，以增强从用靶分子标记的荧光团发射的荧光信号的强度，并通过捕获分子和靶分子之间的特异性结合固定在间隔基上。

公开(公告)号：US20080233752A1

公开(公告)日：2008-09-25

申请号：US11927810

申请日：2007-10-30

申请人： Sang-Choon KO ,  Chi-Hoon JUN ,  Hyeon-Bong PYO ,  Seon-Hee PARK

发明人： Sang-Choon KO ,  Chi-Hoon JUN ,  Hyeon-Bong PYO ,  Seon-Hee PARK

IPC分类号： H01L21/306

CPC分类号： B81C1/00801 ,  B81C2201/0133 ,  B81C2201/0136

摘要： Provided is a method for manufacturing a floating structure of a MEMS. The method for manufacturing a floating structure of a microelectromechanical system (MEMS), comprising the steps of: a) forming a sacrificial layer including a thin layer pattern doped with impurities on a substrate; b) forming a support layer on the sacrificial layer; c) forming a structure to be floated on the support layer by using a subsequent process; d) forming an etch hole exposing both side portions of the thin layer pattern; and e) removing the sacrificial layer through the etch hole to form an air gap between the support layer and the substrate.

摘要翻译： 提供了一种用于制造MEMS的浮动结构的方法。 一种用于制造微机电系统（MEMS）的浮动结构的方法，包括以下步骤：a）在衬底上形成包含掺杂有杂质的薄层图案的牺牲层; b）在牺牲层上形成支撑层; c）通过使用随后的方法形成浮在支撑层上的结构; d）形成暴露薄层图案的两侧部分的蚀刻孔; 以及e）通过所述蚀刻孔去除所述牺牲层，以在所述支撑层和所述基底之间形成气隙。

公开(公告)号：US20080072964A1

公开(公告)日：2008-03-27

申请号：US11675146

申请日：2007-02-15

申请人： Sung-Jin KIM ,  Kwang-Hyo CHUNG ,  Hyeon-Bong PYO

发明人： Sung-Jin KIM ,  Kwang-Hyo CHUNG ,  Hyeon-Bong PYO

IPC分类号： F15B5/00

CPC分类号： B01L3/502746 ,  B01J2219/00837 ,  B01J2219/00891 ,  B01L2200/0636 ,  B01L2400/088 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/2278 ,  Y10T137/87571 ,  Y10T137/87917

摘要： Provided are a microfluidic device and a microfluidic network formed by connecting such microfluidic devices. The microfluidic device can equalize the flow of multiple microfluids in a chamber in parallel to thereby have an equal flow rate when the microfluids transferred through different flow channels join in the chamber having a changing cross-sectional area. The microfluidic device includes: multiple flow channels formed between an upper substrate and a lower substrate to transfer the microfluids and including inlets for injecting the microfluids in one side and fluid stopping surfaces for stopping the flow of the microfluids in the other side; a pressure controlling flow channel for removing a pressure difference between the microfluids; a fluid converging part for converging the microfluids; and a chamber composed of hydrophilic surfaces and hydrophobic surfaces disposed alternately in a flow direction so that the microfluids join and flow in parallel and equal.

摘要翻译： 提供了通过连接这种微流体装置形成的微流体装置和微流体网络。 微流体装置可以平行地均衡腔室中的多个微流体的流动，从而当通过不同流动通道传送的微流体连接在具有变化的横截面积的腔室中时具有相等的流速。 微流体装置包括：在上基板和下基板之间形成的多个流动通道，以转移微流体并且包括用于在一侧注入微流体的入口和用于阻止另一侧的微流体流动的流体停止表面; 用于去除所述微流体之间的压力差的压力控制流路; 用于会聚微流体的流体收敛部分; 以及由流动方向交替设置的亲水性表面和疏水性表面构成的室，使得微流体并流并平行流动。

公开(公告)号：US20080134753A1

公开(公告)日：2008-06-12

申请号：US11951986

申请日：2007-12-06

申请人： Chi-Hoon JUN ,  Sang-Choon KO ,  Hyeon-Bong PYO ,  Seon-Hee PARK

发明人： Chi-Hoon JUN ,  Sang-Choon KO ,  Hyeon-Bong PYO ,  Seon-Hee PARK

IPC分类号： G01N7/00

CPC分类号： G01N27/128

摘要： Provided are a micro gas sensor for measuring a gas concentration configured to achieve a high heating and cooling rate of a gas sensitive layer, achieve temperature uniformity, and achieve durability against thermal impact and mechanical impact; and a method for manufacturing the micro gas sensor. The micro gas sensor includes: a vacuum cavity disposed in a substrate; a support layer covering the vacuum cavity; a sealing layer sealing the support layer and the vacuum cavity; a micro heater disposed on the sealing layer; a plurality of electrodes disposed on the micro heater, insulated from the micro heater; and a gas sensitive layer covering the electrodes.

摘要翻译： 提供一种微气体传感器，用于测量构成为实现气敏感层的高加热和冷却速度的气体浓度，实现温度均匀性，并且实现耐热冲击和机械冲击的耐久性; 以及微气体传感器的制造方法。 微气体传感器包括：设置在基板中的真空腔; 覆盖真空腔的支撑层; 密封层，密封支撑层和真空腔; 设置在密封层上的微加热器; 设置在微加热器上的多个电极，与微加热器绝缘; 以及覆盖电极的气敏层。

公开(公告)号：US20120262930A1

公开(公告)日：2012-10-18

申请号：US13436750

申请日：2012-03-30

申请人： Hyeon-Bong PYO

发明人： Hyeon-Bong PYO

IPC分类号： F21V21/00

CPC分类号： H01S3/2308 ,  H01S3/005

摘要： Provided is an apparatus for enhancing light source intensity. The apparatus for enhancing light source intensity includes a light source outputting light having an ultrashort pulse width, a dielectric substrate, and metal nanostructures disposed on the dielectric substrate, wherein the metal nanostructures are combined with the light having an ultrashort pulse width on the dielectric substrate to generate a surface plasmon polariton resonance.

摘要翻译： 提供了一种用于增强光源强度的装置。 用于增强光源强度的装置包括：输出具有超短脉冲宽度的光的光源，电介质基板和设置在电介质基板上的金属纳米结构，其中金属纳米结构与介电基片上具有超短脉冲宽度的光结合 以产生表面等离子体极化子共振。

公开(公告)号：US20080130004A1

公开(公告)日：2008-06-05

申请号：US11949744

申请日：2007-12-03

申请人： Hyeon-Bong PYO ,  Seon-Hee PARK

发明人： Hyeon-Bong PYO ,  Seon-Hee PARK

IPC分类号： G01N21/55

CPC分类号： G01N21/553 ,  G01N21/211 ,  G01N21/274 ,  G01N21/8422

摘要： There is provided a surface plasmon resonance imaging sensor capable of performing absolute calibration comprising: a transparent substrate; a first prism and a second prism formed at one surface of the substrate and symmetrically positioned with reference to the center axis of the substrate; an optical system for providing light to the first and second prisms; and a light receiving part for detecting the light reflected from the substrate, wherein a surface plasmon resonance (SPR) angle change of an object to be measured by the first prism is measured, and a refractive index change on each pixel of the object is obtained as a two-dimensional difference image by the second prism.

摘要翻译： 提供能够执行绝对校准的表面等离子体共振成像传感器，包括：透明基板; 形成在所述基板的一个表面并相对于所述基板的中心轴对称地定位的第一棱镜和第二棱镜; 用于向第一和第二棱镜提供光的光学系统; 以及用于检测从基板反射的光的光接收部分，其中测量由第一棱镜测量的物体的表面等离子体共振（SPR）角度变化，并且获得物体的每个像素上的折射率变化 作为第二棱镜的二维差分图像。