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公开(公告)号：US09117513B2
公开(公告)日：2015-08-25
申请号：US13554635
申请日：2012-07-20
申请人： Hyun-Sang Hwang , Xinjun Liu , Myoung-Woo Son
发明人： Hyun-Sang Hwang , Xinjun Liu , Myoung-Woo Son
CPC分类号： G11C13/0021 , G11C13/0002 , G11C13/0004 , G11C13/0007 , G11C13/003 , G11C13/0069 , G11C2013/0073 , G11C2013/0083 , G11C2213/15 , G11C2213/55 , G11C2213/76 , H01L45/08 , H01L45/12 , H01L45/1233 , H01L45/1253 , H01L45/146 , H01L45/1633
摘要： A resistive random access memory (ReRAM) includes a first electrode, a threshold switching layer formed over the first electrode and configured to perform a switching operation according to an applied voltage, a resistance change layer formed over the threshold switching layer, and configured to perform a resistance change operation, and a second electrode formed over the resistance change layer, wherein the threshold switching layer comprises a stoichiometric transition oxide while the resistance change layer comprises a non-stoichiometric transition metal oxide.
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公开(公告)号：US20130021835A1
公开(公告)日：2013-01-24
申请号：US13554635
申请日：2012-07-20
申请人： Hyun-Sang Hwang , Xinjun Liu , Myoung-Woo Son
发明人： Hyun-Sang Hwang , Xinjun Liu , Myoung-Woo Son
CPC分类号： G11C13/0021 , G11C13/0002 , G11C13/0004 , G11C13/0007 , G11C13/003 , G11C13/0069 , G11C2013/0073 , G11C2013/0083 , G11C2213/15 , G11C2213/55 , G11C2213/76 , H01L45/08 , H01L45/12 , H01L45/1233 , H01L45/1253 , H01L45/146 , H01L45/1633
摘要： A resistive random access memory (ReRAM) includes a first electrode, a threshold switching layer formed over the first electrode and configured to perform a switching operation according to an applied voltage, a resistance change layer formed over the threshold switching layer, and configured to perform a resistance change operation, and a second electrode formed over the resistance change layer, wherein the threshold switching layer comprises a stoichiometric transition oxide while the resistance change layer comprises a non-stoichiometric transition metal oxide.
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3.发明授权Antibody-based arrays for detecting multiple signal transducers in rate circulating cells 有权用于在稀有循环细胞中检测多个信号传感器的基于抗体的阵列公开(公告)号：US08658388B2
公开(公告)日：2014-02-25
申请号：US12046381
申请日：2008-03-11
申请人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
发明人： Jeanne Harvey , Sharat Singh , Phillip Kim , Xinjun Liu , Robert Barham , Limin Liu
IPC分类号： G01N33/573 , C07H21/04
CPC分类号： G01N33/574 , C40B30/08 , C40B40/10 , G01N33/542 , G01N33/57415 , G01N33/582 , G01N33/6845 , G01N33/6854 , G01N2333/902 , G01N2333/908
摘要： The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.
摘要翻译： 本发明提供用于检测稀有循环细胞中多个信号转导分子的活化状态和/或总量的基于抗体的阵列及其用于促进癌症预后和诊断以及个性化靶向治疗的设计的方法。
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公开(公告)号：US08558023B2
公开(公告)日：2013-10-15
申请号：US13090632
申请日：2011-04-20
申请人： Zijun Liu , Sanhui Lin , Wenge Li , Jingyang Zhu , Xinjun Liu , Xiaojuan Zhang , Hui Lu , Fei Xiong , Zhongwei Tian
发明人： Zijun Liu , Sanhui Lin , Wenge Li , Jingyang Zhu , Xinjun Liu , Xiaojuan Zhang , Hui Lu , Fei Xiong , Zhongwei Tian
IPC分类号： C07C229/28 , C07C229/32
CPC分类号： C07C47/47 , C07C227/06 , C07C231/10 , C07C231/12 , C07C231/18 , C07C233/86 , C07C2601/10 , C07D209/52 , C07D263/42 , C07C229/28
摘要： A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril:
摘要翻译： 制备具有以下结构的对映体富集的环烯烃取代的丙氨酸化合物的方法：通过不对称地氢化具有以下结构的脱氢氨基酸化合物：在合适的反应介质中，在具有与手性膦配体复合的过渡金属部分的催化剂存在下， 制备具有式（IA）或（IB）结构的对映体富集的环烯烃取代的丙氨酸化合物，其是ACE抑制剂雷米普利和perindolpril的关键中间体：
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5.发明申请公开(公告)号：US20130237436A9
公开(公告)日：2013-09-12
申请号：US13014674
申请日：2011-01-26
申请人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
发明人： Sharat Singh , Phillip Kim , Xinjun Liu , Belen Ybarrondo
IPC分类号： C40B30/04
CPC分类号： G01N33/5011 , G01N33/5041
摘要： The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer.
摘要翻译： 本发明提供了选择合适的抗癌疗法以及鉴定和预测胃癌治疗反应的方法。
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公开(公告)号：US09726669B2
公开(公告)日：2017-08-08
申请号：US12854144
申请日：2010-08-10
申请人： Phillip Kim , Xinjun Liu , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Phillip Kim , Xinjun Liu , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
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7.发明授权公开(公告)号：US09488654B2
公开(公告)日：2016-11-08
申请号：US13545947
申请日：2012-07-10
申请人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , G01N2333/71 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译： 本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。 关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。
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8.发明授权公开(公告)号：US08609349B2
公开(公告)日：2013-12-17
申请号：US13439737
申请日：2012-04-04
申请人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
发明人： Sharat Singh , Jeanne Harvey , Phillip Kim , Xinjun Liu , Limin Liu , Robert Barham , Bruce Neri
IPC分类号： G01N33/50 , G01N33/548 , C12Q1/26 , C12Q1/28
CPC分类号： G01N33/57415 , G01N33/5011 , G01N2800/52 , G01N2800/60
摘要： The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译： 本发明提供用于检测肿瘤细胞中信号转导途径的组分的激活状态的组合物和方法。 关于使用本发明的信号转导途径的组分的激活状态的信息可用于癌症诊断，预后和癌症治疗的设计。
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9.发明申请公开(公告)号：US20130012407A1
公开(公告)日：2013-01-10
申请号：US13545947
申请日：2012-07-10
申请人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
发明人： Xinjun Liu , Phillip Kim , Richard Kirkland , Tani Lee , Belen Ybarrondo , Sharat Singh
IPC分类号： C40B30/04
CPC分类号： G01N33/57415 , G01N2333/71 , G01N2800/52
摘要： The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.
摘要翻译： 本发明提供用于检测肿瘤细胞如三阴性转移性乳腺肿瘤细胞中的信号转导途径的组分的表达和/或活化水平的组合物和方法。 关于衍生自本发明的信号转导途径的组分的表达和/或活化水平的信息可用于癌症诊断，预后和癌症治疗的设计。
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公开(公告)号：US20110257408A1
公开(公告)日：2011-10-20
申请号：US13090632
申请日：2011-04-20
申请人： Zijun Liu , Sanhui Lin , Wenge Li , Jingyang Zhu , Xinjun Liu , Xiaojuan Zhang , Hui Lu , Fei Xiong , Zhongwei Tian
发明人： Zijun Liu , Sanhui Lin , Wenge Li , Jingyang Zhu , Xinjun Liu , Xiaojuan Zhang , Hui Lu , Fei Xiong , Zhongwei Tian
IPC分类号： C07C229/32 , C07D263/42 , C07C47/47 , C07C47/457 , C07C227/32 , C07D209/52
CPC分类号： C07C47/47 , C07C227/06 , C07C231/10 , C07C231/12 , C07C231/18 , C07C233/86 , C07C2601/10 , C07D209/52 , C07D263/42 , C07C229/28
摘要： A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure: by asymmetrically hydrogenating a dehydro amino acid compound having the structure: in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril:
摘要翻译： 制备具有以下结构的对映体富集的环烯烃取代的丙氨酸化合物的方法：通过不对称地氢化具有以下结构的脱氢氨基酸化合物：在合适的反应介质中，在具有与手性膦配体复合的过渡金属部分的催化剂存在下， 制备具有式（IA）或（IB）结构的对映体富集的环烯烃取代的丙氨酸化合物，其是ACE抑制剂雷米普利和perindolpril的关键中间体：
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