公开(公告)号：US09274131B2

公开(公告)日：2016-03-01

申请号：US14293661

申请日：2014-06-02

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shao-Hsing Yeh ,  Yu-Ying Lin ,  Chi-Han Chiou ,  Liang-Ju Chien

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N35/00 ,  B03C1/01 ,  B03C1/033 ,  B03C1/035 ,  B03C1/28 ,  B01L3/00

CPC classification number: G01N35/0098 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2300/087 ,  B01L2400/043 ,  B03C1/01 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N1/28 ,  Y10T137/0391 ,  Y10T137/206 ,  Y10T137/2191 ,  Y10T137/2224

Abstract: The disclosure relates to a droplet manipulating device and a method for manipulating a droplet. The droplets manipulating device includes a first magnetic field generator, a second magnetic field generator, and a flow channel. The first magnetic field generator produces a first magnetic field on the droplet, so that the droplet has the direction of magnetic field corresponding to the first magnetic field. Further, the second magnetic field generator produces a second magnetic field on the droplet so as to drive the droplet to be in motion in the flow channel.

Abstract translation: 本发明涉及液滴操纵装置和操纵液滴的方法。 液滴操纵装置包括第一磁场发生器，第二磁场发生器和流动通道。 第一磁场发生器在液滴上产生第一磁场，使得液滴具有对应于第一磁场的磁场方向。 此外，第二磁场发生器在液滴上产生第二磁场，以便驱动液滴在流动通道中运动。

公开(公告)号：US20150029491A1

公开(公告)日：2015-01-29

申请号：US14221286

申请日：2014-03-21

Applicant: Industrial Technology Research Institute

Inventor： Liang-Ju Chien ,  Chi-Han Chiou ,  Shao-Hsing Yeh ,  Yu-Ying Lin

IPC: G01N1/28

CPC classification number: G01N35/0098 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2300/087 ,  B01L2300/1861 ,  B01L2400/043

Abstract: A apparatus for microfluid detection for detecting a sample fluid including a plurality of magnetic particles is provided. The apparatus for microfluid detection includes a microfluidic chip and a magnetic generating module. The microfluidic chip includes a substrate and microfluidic channels, wherein the sample fluid is carried by a carry surface of the substrate. The magnetic generating module is adapted for providing a positioning magnetic field and a surrounding magnetic field. The magnetic module controls to move the sample fluid and change a distribution of the magnetic particles in the sample fluid through the positioning magnetic field and the surrounding magnetic field.

Abstract translation: 提供了一种用于检测包括多个磁性颗粒的样品流体的微流体检测装置。 用于微流体检测的装置包括微流体芯片和磁发生模块。 微流体芯片包括基底和微流体通道，其中样品流体由基底的携带表面承载。 磁性发生模块适于提供定位磁场和周围磁场。 磁性模块控制移动样品流体并通过定位磁场和周围磁场改变样品流体中磁性颗粒的分布。

公开(公告)号：US09279820B2

公开(公告)日：2016-03-08

申请号：US14706353

申请日：2015-05-07

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shao-Hsing Yeh ,  Yu-Ying Lin ,  Chi-Han Chiou ,  Liang-Ju Chien

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N35/00 ,  G01N1/28

CPC classification number: G01N35/0098 ,  B01L3/502761 ,  B01L3/502784 ,  B01L2200/0647 ,  B01L2300/087 ,  B01L2400/043 ,  B03C1/01 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N1/28 ,  Y10T137/0391 ,  Y10T137/206 ,  Y10T137/2191 ,  Y10T137/2224

Abstract: A method for manipulating a droplet by a droplet manipulating device including a flow channel, a first magnetic field generator, and a second magnetic field generator is provided. The first magnetic field generator includes two first magnetic field modules and are at two sides of the flow channel. The second magnetic field generator is between the two first magnetic field modules and includes multiple second magnetic field coils. The droplet is provided in the flow channel and includes a magnetic particle. A first magnetic field is produced on the flow channel by the first magnetic field modules, so the magnetic particle in the droplet has the direction of magnetic field corresponding to the first magnetic field. A second magnetic field is produced on the flow channel by the second magnetic field coils, for driving the magnetic particle in the droplet to be in motion in the flow channel.

Abstract translation: 提供了一种通过包括流动通道的液滴操纵装置来操纵液滴的方法，第一磁场发生器和第二磁场发生器。 第一磁场发生器包括两个第一磁场模块，并且位于流动通道的两侧。 第二磁场发生器位于两个第一磁场模块之间，并且包括多个第二磁场线圈。 液滴设置在流路中并包括磁性颗粒。 通过第一磁场模块在流动通道上产生第一磁场，因此液滴中的磁性颗粒具有对应于第一磁场的磁场方向。 通过第二磁场线圈在流路上产生第二磁场，用于驱动液滴中的磁性颗粒在流动通道中运动。

公开(公告)号：US09341639B2

公开(公告)日：2016-05-17

申请号：US14221286

申请日：2014-03-21

Applicant: Industrial Technology Research Institute

Inventor： Liang-Ju Chien ,  Chi-Han Chiou ,  Shao-Hsing Yeh ,  Yu-Ying Lin

IPC: G01N35/00 ,  B01L3/00

CPC classification number: G01N35/0098 ,  B01L3/502792 ,  B01L2200/0668 ,  B01L2300/087 ,  B01L2300/1861 ,  B01L2400/043

Abstract: A apparatus for microfluid detection for detecting a sample fluid including a plurality of magnetic particles is provided. The apparatus for microfluid detection includes a microfluidic chip and a magnetic generating module. The microfluidic chip includes a substrate and microfluidic channels, wherein the sample fluid is carried by a carry surface of the substrate. The magnetic generating module is adapted for providing a positioning magnetic field and a surrounding magnetic field. The magnetic module controls to move the sample fluid and change a distribution of the magnetic particles in the sample fluid through the positioning magnetic field and the surrounding magnetic field.

Abstract translation: 提供了一种用于检测包括多个磁性颗粒的样品流体的微流体检测装置。 用于微流体检测的装置包括微流体芯片和磁发生模块。 微流体芯片包括基底和微流体通道，其中样品流体由基底的携带表面承载。 磁性发生模块适于提供定位磁场和周围磁场。 磁性模块控制移动样品流体并通过定位磁场和周围磁场改变样品流体中磁性颗粒的分布。