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公开(公告)号：US10357297B2
公开(公告)日：2019-07-23
申请号：US14554521
申请日：2014-11-26
发明人： Pei-Yi Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hsin-Hsin Shen , Yi-Hung Lin , De-Yau Lin , Jui-Sheng Sun , Chuan-Sheng Chuang , An-Li Chen , Ching-Chih Lin
摘要： A bionic apparatus is provided. The bionic apparatus includes a flexible portion having a plurality of pores, a rigid portion connected with the flexible portion, and a supporting element disposed in the flexible portion. The pore size of each pore is between 50 μm to 500 μm. The flexible portion, the rigid portion and the supporting element are one-piece formed by a additive manufacturing process.
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公开(公告)号：US10507041B2
公开(公告)日：2019-12-17
申请号：US14555251
申请日：2014-11-26
发明人： Pei-Yi Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hsin-Hsin Shen , Yi-Hung Lin , De-Yau Lin , Jui-Sheng Sun , Chuan-Sheng Chuang , An-Li Chen , Ching-Chih Lin
IPC分类号： A61B17/68
摘要： A bionic fixing apparatus is provided. The bionic fixing apparatus includes a body having a through hole and at least one slit. The through hole penetrates the body from the top surface to the bottom surface to form a top opening and a bottom opening. An inner diameter of the top opening is larger than an inner diameter of the bottom opening. The slit is connected to the bottom opening and extends upwardly from the bottom surface of the body, such that the body has a flexible bottom portion.
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公开(公告)号：US09770276B2
公开(公告)日：2017-09-26
申请号：US14555204
申请日：2014-11-26
发明人： Pei-Yi Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hsin-Hsin Shen , Yi-Hung Lin , De-Yau Lin , Jui-Sheng Sun , Chuan-Sheng Chuang , An-Li Chen , Ching-Chih Lin
CPC分类号： A61B17/8625 , A61B17/72 , A61C8/0018 , A61C8/0022 , A61C8/0037 , A61C2008/0046 , A61F2/442
摘要： A bionic fixing apparatus is provided. The bionic fixing apparatus includes a flexible portion having at least one trench. The trench is disposed on the surface of the flexible portion and has a first end and a second end. An interval is disposed between the first end and the second end. The trench is disposed for spreading the stress applied on the bionic fixing apparatus and preventing stress concentration and stress shielding.
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公开(公告)号：US20170156878A1
公开(公告)日：2017-06-08
申请号：US14977234
申请日：2015-12-21
发明人： Jane SC Tsai , Hsin-Hsin Shen , Fang-Hei Tsau , Ji-Bin Horng , Pei-Yi Tsai , Chih-Chieh Huang , Yi-Hung Wen , Hong-Jen Lai , Sung-Ho Liu , Ching-Chih Lin , Meng-Huang Wu
CPC分类号： A61F2/442 , A61B17/86 , A61F2/4455 , A61F2/447 , A61F2002/30733 , A61F2002/30784 , A61F2002/3092 , A61F2002/3093 , A61F2002/4475 , A61F2002/4495
摘要： An implant device for osseous integration includes a plurality of connection bars and at least one frame bar. These connection bars are connected with each other to form a three-dimensional (3D) grid structure. The frame bar is connected with at least two of the connection bars to define at least one edge of the 3D grid structure. Wherein, the frame bar has a diameter substantially greater than that of these connection bars.
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公开(公告)号：US11242516B2
公开(公告)日：2022-02-08
申请号：US16137925
申请日：2018-09-21
发明人： Pei-Yi Tsai , Chih-Hung Chen , Yi-Hung Lin , Chih-Chieh Huang , Hsin-Hsin Shen , Liang-Yin Ke , Chu-Huang Chen
摘要： A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.
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6.发明申请BIOCHEMISTRY REACTIVE MATERIAL AND DEVICE FOR ELIMINATING ELECTRONEGATIVE LOW-DENSITY LIPOPROTEIN (LDL) AND METHOD FOR TREATING BLOOD OR PLASMA EX VIVO TO ELIMINATE ELECTRONEGATIVE LOW-DENSITY LIPOPROTEIN THEREIN 审中-公开用于消除电子低密度脂蛋白（LDL）的生物化学反应性材料和装置以及用于治疗血液或血浆的方法以消除电子密度低密度脂蛋白公开(公告)号：US20170044516A1
公开(公告)日：2017-02-16
申请号：US14984938
申请日：2015-12-30
发明人： Pei-Yi Tsai , Chih-Hung CHEN , Yi-Hung LIN , Chih-Chieh HUANG , Hsin-Hsin SHEN , Liang-Yin KE , Chu-Huang CHEN
CPC分类号： C12N11/12 , A61M1/3486 , A61M2202/08 , C12M45/09 , C12N11/10 , C12N11/14
摘要： The present disclosure provides a biochemistry reactive material, including a substrate and an enzyme composition immobilized on the substrate. The enzyme composition is selected from a group consisting of a first enzyme, a second enzyme, and a combination thereof. The first enzyme is used for eliminating a glycan residue of an electronegative low-density lipoprotein (electronegative LDL). The second enzyme is used for eliminating ceramide carried by an electronegative low-density lipoprotein. The biochemistry reactive material is capable of eliminating electronegative low-density lipoprotein.
摘要翻译： 本公开提供了生物化学反应性材料，其包括固定在基材上的底物和酶组合物。 酶组合物选自第一酶，第二酶及其组合。 第一种酶用于消除电负性低密度脂蛋白（电负性LDL）的聚糖残基。 第二种酶用于消除由负电性低密度脂蛋白携带的神经酰胺。 生物化学反应性材料能够消除电负性低密度脂蛋白。
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