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公开(公告)号：US11236343B2
公开(公告)日：2022-02-01
申请号：US16346251
申请日：2017-11-01
Inventor： Won Jong Kim , Jeong Hun Kim , Jihyun Lee , Byung Joo Lee
IPC: C12N15/115 , A61K47/61 , A61P27/02 , A61P35/00 , A61K31/713
Abstract: The present invention relates to a method for producing dextran polymer-based amplified nucleic acid aptamer nanoconstructs which efficiently and selectively capture a specific target molecule, the method comprising linking a short nucleic acid sequence or a complementary sequence for formation of nanoconstructs and a nucleic acid aptamer sequence for capture of the specific target molecule to a dextran polymer by a chemical reaction, mixing the resulting polymer/nucleic acid substances with each other to form nanostructures, subjecting the nanostructures to rolling circle amplification, thereby forming a nucleic acid aptamer having a repeated structure. The dextran polymer-based amplified nucleic acid aptamer nanoconstructs have the effect of efficiently and selectively capturing a specific target molecule.
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公开(公告)号：US10517963B2
公开(公告)日：2019-12-31
申请号：US15337252
申请日：2016-10-28
Inventor： Won Jong Kim , Jinhwan Kim
Abstract: Provided is a gene delivery including a polymer network formed by binding phenylboronic acid, sugar, and a low-molecular weight branched polymer. The gene delivery may be stably maintained in vivo and efficiently deliver a gene specifically to cancer cells, such that the gene delivery system may be usefully used as a gene delivery system for chemotherapy.
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3.发明授权公开(公告)号：US10301332B2
公开(公告)日：2019-05-28
申请号：US15359474
申请日：2016-11-22
Inventor： Won Jong Kim , Jihoon Kim , Hyung Woo Choi
IPC: C07F7/18 , B01J20/04 , B01J20/22 , A61K33/00 , C01B21/24 , A61K31/655 , A61K31/695 , A61K47/54 , A61K47/69 , B82Y5/00
Abstract: Provided is a method of controlling release of nitric oxide, and more particularly, to a method of selectively releasing nitric oxide depending on a change in pH using calcium phosphate.The method of selectively releasing nitric oxide according to the present invention may stably deliver nitric oxide to a desired site, and induce release of nitric oxide by a change in pH, thereby making it possible to improve a therapeutic effect while preventing a loss of nitric oxide.
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Patent Agency Ranking
公开(公告)号：US11981780B2
公开(公告)日：2024-05-14
申请号：US16606143
申请日：2018-04-18
Inventor： Won Jong Kim , Junghong Park
CPC classification number: C08J3/075 , C08J3/24 , F01N11/00 , C08J2387/00 , F01N2570/12 , G02C7/04
Abstract: The present invention relates to a polymeric gel comprising crosslink points, which are dissociated in response to nitrogen monoxide, and to a method for preparing a hydrogel, the method comprising the steps of: a) polymerizing a mixture of monomers comprising a monofunctional hydrophilic monomer and a monomer comprising a plurality of functional groups comprising an o-phenylenediamine residue; and b) separating a hydrogel formed by the polymerization.
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公开(公告)号：US11414667B2
公开(公告)日：2022-08-16
申请号：US16963315
申请日：2018-04-13
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong Kim , Ji Hyun Lee
IPC: C12N15/115 , A61K31/713 , C12Q1/6886
Abstract: The present invention relates to a highly efficient aptamer complex comprising a branched DNA and an aptamer, and a pharmaceutical use thereof. More specifically, the aptamer complex of the present invention relates to a highly efficient aptamer complex including a Y-shaped DNA as the branched DNA and using vascular endothelial growth factor (VEGF) as a target molecule. The aptamer complex of the present invention and a pharmaceutical composition comprising the same as an active ingredient are expected to be widely used in the medical field since the binding efficiency with the target molecule is more remarkable than that of the conventional aptamer.
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6.发明申请公开(公告)号：US20150051269A1
公开(公告)日：2015-02-19
申请号：US14384509
申请日：2013-03-12
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION , KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC CORPORATION FOUNDATION
Inventor： Won Jong Kim , Ran Namgung , Byung Heon Lee , In San Kim , Allan Hoffman
IPC: A61K31/337 , A61K47/48 , A61K47/40
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/5161 , A61K47/58 , A61K47/62 , A61K47/6951 , B82Y5/00
Abstract: The present invention relates to a hydrophobic drug delivery conjugate, to which cyclodextrin, poly(maleic anhydride), and a hydrophobic drug are bonded, and to a pharmaceutical composition comprising the hydrophobic drug delivery conjugate as an active ingredient. The hydrophobic drug delivery conjugate according to the present invention can effectively control the release rate and the delivery rate of a hydrophobic drug by regulating the physicochemical bonding and/or composition of the cyclodextrin, poly(maleic anhydride), and hydrophobic drug, and can also increase the effect of the drug by significantly increasing the solubility of the hydrophobic drug. Further, the present invention can enable the type of the hydrophobic drug to be varied, as well as a peptide having target directivity to be introduced into a surface of the conjugate, such that the present invention can be applied to the treatment of various diseases in addition to cancer treatment.
Abstract translation: 本发明涉及结合了环糊精，聚（马来酸酐）和疏水性药物的疏水性药物递送缀合物，以及包含疏水药物递送缀合物作为活性成分的药物组合物。 根据本发明的疏水药物递送缀合物可以通过调节环糊精，聚（马来酸酐）和疏水性药物的物理化学键合和/或组成来有效地控制疏水性药物的释放速率和释放速率，并且还可以 通过显着增加疏水性药物的溶解度来增加药物的作用。 此外，本发明能够使疏水性药物的种类以及具有靶向性的肽引入缀合物的表面，使得本发明可以应用于各种疾病的治疗 除了癌症治疗。
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公开(公告)号：US11426426B2
公开(公告)日：2022-08-30
申请号：US17182504
申请日：2021-02-23
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong Kim , Ji Won Yeo
IPC: A61K31/785 , A61K9/00 , A61K9/06
Abstract: The invention relates to a nitric oxide-responsive acrylamide-based polymer, and more particularly, to an acrylamide-based polymer that is produced using an acrylamide-based monomer and a nitric oxide-sensitive crosslinking agent and allows prevention or treatment of a disease or illness caused by overexpression of nitric oxide.
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公开(公告)号：US09623156B2
公开(公告)日：2017-04-18
申请号：US13860899
申请日：2013-04-11
Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
Inventor： Won Jong Kim , Jihoon Kim , Haeshin Lee , Seonki Hong
CPC classification number: A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/114
Abstract: A method of coating surfaces of various body-implantable materials with control-releasable nitrogen monoxide using a catecholamine, more particularly, technology of preparing a coating film containing a diazeniumdiolate functional group on a surface of a material to be coated using a catecholamine, is provided. The coating film prepared by the method has advantages in that nitrogen monoxide can be stably supplied under an in vivo environment, and can be suitably used in a living body without causing cytotoxicity. Therefore, among the materials having a coating film formed on a surface thereof, the body-implantable material is especially expected to be widely used for medical and health applications including treatment of ischemic disorders such as arteriosclerosis through controlled release of nitrogen monoxide, regulation of penile erections, antibacterial and antiviral effects, and wound healing.
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