公开(公告)号：US11596659B2

公开(公告)日：2023-03-07

申请号：US15930394

申请日：2020-05-12

申请人： iNtRON Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Jee Soo Son ,  In Hwang Kim ,  Hyoung Rok Paik ,  Hyun Joo Im ,  Hyun Jin Yu ,  Cheol Ahn ,  Tae Yeol Kim ,  Soo Youn Jun ,  Sang Hyeon Kang

IPC分类号： A61K35/76 ,  A61K45/06 ,  A61P31/04

摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage Esc-COP-18 having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.

公开(公告)号：US11583565B2

公开(公告)日：2023-02-21

申请号：US16840334

申请日：2020-04-04

申请人： iNtRON Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Jee Soo Son ,  In Hwang Kim ,  Hyoung Rok Paik ,  Hyun Joo Im ,  Ji Young Park ,  Hyun Jin Yu ,  Ji Yeong Seo ,  Soo Youn Jun ,  Sang Hyeon Kang

IPC分类号： A61K35/76 ,  A61K45/06 ,  A61P31/04

摘要： A composition for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes a Myoviridae bacteriophage having an ability to lyse the pathogenic Escherichia coli and a pharmaceutically acceptable carrier. A method for preventing or treating an infection or disease caused by a pathogenic Escherichia coli includes administering to a subject a Myoviridae bacteriophage and lysing the pathogenic Escherichia coli by the Myoviridae bacteriophage.

公开(公告)号：US11492378B2

公开(公告)日：2022-11-08

申请号：US17100232

申请日：2020-11-20

申请人： Intron Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Myung Soo Kang ,  Soo Youn Jun ,  Jong Hyun Kim ,  Gi Mo Jung ,  Jee Soo Son ,  Hyoun Rok Paik ,  Sang Hyeon Kang

IPC分类号： C07K14/005 ,  A61P31/04 ,  C12N15/70 ,  A61K38/00

摘要： The present invention relates to an antibacterial protein EFAL-2 derived from bacteriophage Ent-FAP-4 (Accession number: KCTC 12854BP), which has the ability to kill Enterococcus faecium and an amino acid sequence represented by SEQ ID NO: 2, a pharmaceutical composition containing the same as an active ingredient, and a method for preventing or treating diseases caused by Enterococcus faecium using the pharmaceutical composition.

公开(公告)号：US20210054345A1

公开(公告)日：2021-02-25

申请号：US17043847

申请日：2019-02-19

申请人： Intron Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Soo Youn Jun ,  Jee Soo Son ,  Hyoun Rok Paik ,  Beom Seok Kim ,  Sang Hyeon Kang

IPC分类号： C12N7/00 ,  A01N63/40 ,  A61K35/76 ,  A61P31/04 ,  A23K10/16 ,  A23L2/52 ,  A23L33/10

摘要： The present invention relates to a Siphoviridae bacteriophage STP-2 (Accession number: KCTC 12853BP) isolated from nature and characterized by having the ability to destroy Salmonella Typhimurium and having a genome represented by SEQ ID NO:1; and to a method for preventing and treating diseases caused by Salmonella Typhimurium using Siphoviridae bacteriophage STP-2 containing the same as an active ingredient.

公开(公告)号：US10696989B2

公开(公告)日：2020-06-30

申请号：US16475409

申请日：2017-12-06

申请人： INTRON BIOTECHNOLOGY, INC.

发明人： Seong Jun Yoon ,  Jung In Pyo ,  Soon Hye Hwang ,  Soo Youn Jun ,  Sang Hyeon Kang

IPC分类号： C12P9/00 ,  C07D487/22

摘要： The present invention relates to heme iron not derived from porcine blood and a method of preparing the same, and more particularly to a method of biologically preparing heme iron not derived from porcine blood, a method of preparing a salt thereof, and an iron supplement containing the salt thus prepared as an active ingredient.

公开(公告)号：US10568917B2

公开(公告)日：2020-02-25

申请号：US16064747

申请日：2016-11-10

申请人： INTRON BIOTECHNOLOGY, INC.

发明人： Seong Jun Yoon ,  Soo Youn Jun ,  Hyoun Rok Paik ,  Jee Soo Son ,  Dong Min Kang ,  Sang Hyeon Kang

IPC分类号： A61K39/102 ,  A61K35/76 ,  A61K8/99 ,  A23K20/195 ,  C12N7/00 ,  A61Q17/00 ,  A23K10/18 ,  A23K50/30 ,  A23K50/60 ,  A61Q19/10 ,  A23K20/10 ,  A61P31/04

摘要： The present invention relates to: Myoviridae bacteriophage Pas-MUP-1 (accession number KCTC 12706BP) which has the capability to specifically destroy Pasteurella multocida, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Pasteurella multocida infections, using a composition containing bacteriophage Pas-MUP-1 as an active ingredient.

公开(公告)号：US20200055902A1

公开(公告)日：2020-02-20

申请号：US16487508

申请日：2018-01-11

申请人： Intron Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Myung Soo Kang ,  Soo Youn Jun ,  Jong Hyun Kim ,  Gi Mo Jung ,  Jee Soo Son ,  Hyoun Rok Paik ,  Sang Hyeon Kang

IPC分类号： C07K14/005 ,  A61P31/04 ,  C12N15/70

摘要： The present invention relates to an antibacterial protein EFAL-2 derived from bacteriophage Ent-FAP-4 (deposition number KCTC 12854BP), a pharmaceutical composition including the same as an active ingredient, and a method for preventing or treating diseases caused by Enterococcus faecium by using the pharmaceutical composition, the antibacterial protein EFAL-2 being characterized by having the ability capable of killing Enterococcus faecium and having an amino acid sequence represented by SEQ ID NO: 2.

公开(公告)号：US20180369299A1

公开(公告)日：2018-12-27

申请号：US16064698

申请日：2016-11-10

申请人： INTRON BIOTECHNOLOGY, INC.

发明人： Seong Jun Yoon ,  Soo Youn Jun ,  An Sung Kwon ,  Soon Hye Hwang ,  Sang Hyeon Kang

IPC分类号： A61K35/76 ,  A23K20/195 ,  A61P31/04

CPC分类号： A61K35/76 ,  A23K20/195 ,  A23K50/80 ,  A61P31/04 ,  C12N7/00 ,  C12N2795/10221 ,  C12N2795/10232

摘要： The present invention relates to: Podoviridae bacteriophage Vib-PAP-1 (accession number KCTC 12817BP) which has the capability to specifically destroy Vibrio parahaemolyticus, is characterized by having a genome represented by SEQ ID NO: 1, and is isolated from nature; and a method for preventing and treating Vibrio parahaemolyticus infections, using a composition containing bacteriophage Vib-PAP-1 as an active ingredient.

公开(公告)号：US20180303885A1

公开(公告)日：2018-10-25

申请号：US15766497

申请日：2016-09-30

申请人： Intron Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Soo Youn Jun ,  An Sung Kwon ,  Hyun Min Song ,  Sang Hyeon Kang

IPC分类号： A61K35/76 ,  C12N7/00 ,  A61P31/04 ,  A23K10/18 ,  A23K50/80

CPC分类号： A61K35/76 ,  A01N63/00 ,  A23K10/16 ,  A23K10/18 ,  A23K20/158 ,  A23K20/163 ,  A23K20/20 ,  A23K50/80 ,  A61K8/99 ,  A61P31/04 ,  C12N7/00 ,  C12N2795/10321 ,  C12N2795/10332 ,  C12N2795/10371

摘要： The present invention relates to a Siphoviridae bacteriophage Str-INP-1 (Accession NO: KCTC 12687BP) that is isolated from the nature and can kill specifically Streptococcus iniae cells, which has a genome represented by the nucleotide sequence of SEQ. ID. NO: 1, and a method for preventing and treating the infections of Streptococcus iniae using the composition comprising said bacteriophage as an active ingredient.

公开(公告)号：US09540616B2

公开(公告)日：2017-01-10

申请号：US14934920

申请日：2015-11-06

申请人： iNtRON Biotechnology, Inc.

发明人： Seong Jun Yoon ,  Sooyoun Jun ,  Hyoungrok Paik ,  Gimo Jung ,  Yoonsik Shin ,  Sanghyeon Kang

IPC分类号： A61K35/76 ,  C12N7/00

CPC分类号： C12N7/00 ,  A61K35/76 ,  C12N2795/00021 ,  C12N2795/00032 ,  Y02A50/471 ,  Y02A50/481 ,  Y02A50/483

摘要： The present invention relates to a composition comprising bacteriophage SP-1, the bacteriophage capable of destroying Salmonella once being infected in Salmonella, as an active ingredient, and a method for prevention and treatment of Salmonella infection using the same. Bacteriophage SP-1, the active ingredient of the composition of the present invention, characteristically has the killing activity to Salmonella and has the genome represented by SEQ. ID. NO: 1.

摘要翻译： 本发明涉及包含噬菌体SP-1，能够在沙门氏菌中被感染的沙门氏菌的噬菌体作为活性成分的组合物，以及使用该组合物的沙门氏菌感染的预防和治疗方法。 噬菌体SP-1是本发明组合物的活性成分，其特征在于具有沙门氏菌的杀伤活性，并具有SEQ ID NO： ID。 NO：1。