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12 条记录 (耗时 0.036 秒)

    ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS
    5.
    发明申请
    ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS 审中-公开
    从人类皮肤细胞衍生的成年干细胞

    公开(公告)号：US20140170122A1

    公开(公告)日：2014-06-19

    申请号：US14240330

    申请日：2012-08-24

    申请人： Joong Hyun Shim ,  Seung Ha Yang ,  Tae Ryong Lee ,  Hak Hee Kang ,  Dong Wook Shin

    发明人： Joong Hyun Shim ,  Seung Ha Yang ,  Tae Ryong Lee ,  Hak Hee Kang ,  Dong Wook Shin

    IPC分类号： C12N5/0775 ,  A61K35/28

    CPC分类号： C12N5/0668 ,  A61K35/28 ,  A61K35/32 ,  A61K35/35 ,  A61K35/36 ,  C12N5/0625 ,  C12N2533/54 ,  C12Q1/6881 ,  C12Q2600/158 ,  G01N33/74 ,  G01N2333/475 ,  G01N2333/485 ,  G01N2333/49 ,  G01N2333/50

    摘要： Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and adipocytes differentiated from the adult stem cells derived from human skin dermis, and a differentiation method therefor. Further provided in the present invention is a composition for osteogenesis or lipogenesis containing the stem cells, osteoblastic cells, or adipocytes. The isolation method of the present invention enables the adult stem cells derived from human skin dermis to be obtained in an easy and simple manner at a high yield rate. Genes and growth factors which are specifically expressed in the adult stem cells derived from human skin dermis isolated using the method can be separated, identified, and used later.

    摘要翻译： 本发明中提供的是源自人皮肤真皮的成体干细胞及其分离方法。 本发明还提供了从源于人皮肤真皮的成体干细胞分化的成骨细胞和脂肪细胞及其分化方法。 本发明还提供了含有干细胞，成骨细胞或脂肪细胞的成骨或脂肪生成组合物。 本发明的分离方法能够以高产率以容易且简单的方式获得源自人皮肤真皮的成体干细胞。 在使用该方法分离的来自人皮肤真皮的成体干细胞中特异性表达的基因和生长因子可以被分离，鉴定和使用。

    METHOD FOR SCREENING FOR MATERIALS FOR PROMOTING THE DIFFERENTIATION OF SKIN CELLS
    7.
    发明申请
    METHOD FOR SCREENING FOR MATERIALS FOR PROMOTING THE DIFFERENTIATION OF SKIN CELLS 审中-公开
    筛选用于促进皮肤细胞分化的材料的方法

    公开(公告)号：US20130236904A1

    公开(公告)日：2013-09-12

    申请号：US13988270

    申请日：2011-11-18

    申请人： Hyun Choi ,  Yeun Kyung Kim ,  Seung Ha Yang ,  Tae Ryong Lee ,  Min Soo Noh ,  Dong Wook Shin

    发明人： Hyun Choi ,  Yeun Kyung Kim ,  Seung Ha Yang ,  Tae Ryong Lee ,  Min Soo Noh ,  Dong Wook Shin

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/148 ,  C12Q2600/158

    摘要： The present invention relates to a method for screening for materials for promoting the differentiation of skin cells, comprising: a step of treating skin cells with a test material; and a step of checking the relative degree of the expression of the DUOX 1 gene in the skin cells treated with the test material in the previous step. The present invention also relates to a kit for screening for materials for promoting the differentiation of skin cells, comprising a device for checking the relative degree of expression of the DUOX 1 gene in skin cells. The present invention also relates to a composition which contains, as an active ingredient, a material for increasing the expression of the DUOX 1 gene to promote the differentiation of skin cells, moisturize the skin, improve skin barrier function, or alleviate or treat symptoms of atopic dermatitis.

    摘要翻译： 本发明涉及一种用于筛选促进皮肤细胞分化的材料的方法，包括：用试验材料处理皮肤细胞的步骤; 以及检查在前一步骤中用试验材料处理的皮肤细胞中DUOX1基因表达的相对程度的步骤。 本发明还涉及用于筛选用于促进皮肤细胞分化的材料的试剂盒，其包括用于检查皮肤细胞中DUOX1基因的相对表达程度的装置。 本发明还涉及含有作为活性成分的用于增加DUOX1基因表达以促进皮肤细胞分化，增湿皮肤，改善皮肤屏障功能或缓解或治疗 特应性皮炎。

    USE FOR TREATING OBESITY AND DIABETES
    8.
    发明申请
    USE FOR TREATING OBESITY AND DIABETES 审中-公开
    用于治疗肥胖和糖尿病

    公开(公告)号：US20100056560A1

    公开(公告)日：2010-03-04

    申请号：US12447800

    申请日：2007-08-29

    申请人： Hyun Woo Park ,  Ji Young Chun ,  Eui Seok Shin ,  Yoo Kim ,  Tae Ryong Lee ,  Sang Jun Lee

    发明人： Hyun Woo Park ,  Ji Young Chun ,  Eui Seok Shin ,  Yoo Kim ,  Tae Ryong Lee ,  Sang Jun Lee

    IPC分类号： A61K31/352 ,  A61K31/437 ,  A61P3/00

    CPC分类号： A61K31/198 ,  A61K31/205 ,  A61K31/35 ,  A61K2300/00

    摘要： Disclosed herein is the use of a composition, containing isoflavone-containing soybean extract, L-carnitine, caffeine and arginine as active ingredients, for the treatment of obesity and diabetes. The disclosed composition contains isoflavone-containing soybean extract, carnitine, caffeine and arginine in the form of a mixture, and thus shows not only the effect of promoting lipolysis and fat burning, but also anti-obesity and anti-diabetic effects by increasing the expressions of adiponectin and Glut4 genes to restore insulin sensitivity.

    摘要翻译： 本文公开了含有含异黄酮的大豆提取物，L-肉碱，咖啡因和精氨酸作为活性成分的组合物用于治疗肥胖症和糖尿病的用途。 所公开的组合物含有混合物形式的含异黄酮的大豆提取物，肉碱，咖啡因和精氨酸，因此不仅显示促进脂肪分解和脂肪燃烧的效果，而且通过增加表达来显示抗肥胖和抗糖尿病作用 的脂联素和Glut4基因以恢复胰岛素敏感性。

    METHOD FOR CALCULATING A THERMAL PROTECTION FACTOR
    10.
    发明申请
    METHOD FOR CALCULATING A THERMAL PROTECTION FACTOR 有权
    计算热保护因子的方法

    公开(公告)号：US20130329766A1

    公开(公告)日：2013-12-12

    申请号：US14000543

    申请日：2012-02-15

    申请人： Eui Dong Son ,  Hyeon Chung Kim ,  Ji Hyun Kim ,  Hyun Jung Choi ,  Gae Won Nam ,  Tae Ryong Lee ,  Jin Ho Chung ,  Seon Pil Jin

    发明人： Eui Dong Son ,  Hyeon Chung Kim ,  Ji Hyun Kim ,  Hyun Jung Choi ,  Gae Won Nam ,  Tae Ryong Lee ,  Jin Ho Chung ,  Seon Pil Jin

    IPC分类号： G01K11/00

    CPC分类号： G01K11/00 ,  A61B5/01 ,  A61B5/441

    摘要： The present invention relates to a method for calculating a thermal protection factor, wherein the method comprises the steps of: applying heat to a first area coated with a thermal protection material, and a second area not coated with the thermal protection material; measuring the respective saturation temperatures of the first area and second area; calculating a first energy by dividing the energy corresponding to the heat applied to the first area by the saturation temperature of the first area; calculating a second energy by dividing the energy corresponding to the heat applied to the second area by the saturation temperature of the second area; and calculating the thermal protection factor of a thermal protection material by dividing the first energy by the second energy or dividing the difference between the first energy and the second energy by the first energy.

    摘要翻译： 本发明涉及一种计算热保护因子的方法，其中该方法包括以下步骤：将热量施加到涂覆有热保护材料的第一区域和未涂覆有热保护材料的第二区域; 测量第一区域和第二区域的各自的饱和温度; 通过将对应于第一区域的热量的能量除以第一区域的饱和温度来计算第一能量; 通过将对应于第二区域的热量的能量除以第二区域的饱和温度来计算第二能量; 以及通过将第一能量除以第二能量或将第一能量与第二能量之间的差除以第一能量来计算热保护材料的热保护因子。