Cleavable carnitine compound
    3.
    发明授权
    Cleavable carnitine compound 有权
    可切割的肉碱化合物

    公开(公告)号:US08318954B2

    公开(公告)日:2012-11-27

    申请号:US12280572

    申请日:2007-02-23

    IPC分类号: C07D339/04

    摘要: The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound.

    摘要翻译: 本发明包括新化合物,包括但不限于式A和式B,以及改进的递送方法。 这些化合物和方法可用于预防或治疗与自由基存在相关或由其引起的疾病或病症,并且可用于增加细胞代谢同时减轻由此导致的氧化应激增加。 具体地,肉碱与硫辛酸衍生物或二氢硫辛酸或其衍生物结合使用可水解接头以形成单一化合物。

    Cleavable Carnitine Compound
    4.
    发明申请
    Cleavable Carnitine Compound 有权
    可克服的肉碱化合物

    公开(公告)号:US20090312404A1

    公开(公告)日:2009-12-17

    申请号:US12280572

    申请日:2007-02-23

    摘要: The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound.

    摘要翻译: 本发明包括新化合物,包括但不限于式A和式B,以及改进的递送方法。 这些化合物和方法可用于预防或治疗与自由基存在相关或由其引起的疾病或病症,并且可用于增加细胞代谢同时减轻由此导致的氧化应激增加。 具体地,肉碱与硫辛酸衍生物或二氢硫辛酸或其衍生物结合使用可水解接头以形成单一化合物。

    Process for the production of N,N-carbonyl diimidazole
    5.
    发明授权
    Process for the production of N,N-carbonyl diimidazole 失效
    制备N,N-羰基二咪唑的方法

    公开(公告)号:US06455702B1

    公开(公告)日:2002-09-24

    申请号:US09983338

    申请日:2001-10-24

    IPC分类号: C07D23354

    CPC分类号: C07D233/54

    摘要: A high purity N,N-Carbonyl diimidazole (I) is obtained by the reaction of Imidazole, general formula-II, and bis (trichloromethyl) carbonate. Synthesis of N,N-Carbonyl diimidazole (I) is described:

    摘要翻译: 通过咪唑,通式II和碳酸双(三氯甲基)酯的反应获得高纯度N,N-羰基二咪唑(I)。 描述了N,N-羰基二咪唑(I)的合成: