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公开(公告)号：US20090312404A1
公开(公告)日：2009-12-17
申请号：US12280572
申请日：2007-02-23
IPC分类号： A61K31/385 , C07D339/04 , A61P43/00
CPC分类号： A61K31/205 , A61K31/385 , A61K47/542 , A61K47/55 , A61K2300/00
摘要： The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound.
摘要翻译： 本发明包括新化合物，包括但不限于式A和式B，以及改进的递送方法。 这些化合物和方法可用于预防或治疗与自由基存在相关或由其引起的疾病或病症，并且可用于增加细胞代谢同时减轻由此导致的氧化应激增加。 具体地，肉碱与硫辛酸衍生物或二氢硫辛酸或其衍生物结合使用可水解接头以形成单一化合物。
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公开(公告)号：US08318954B2
公开(公告)日：2012-11-27
申请号：US12280572
申请日：2007-02-23
申请人： Inder Pal Singh , Shradha Singh , Antoine Noujiam , Bruce D. Hirsche, legal representative , David S. Tam
发明人： Inder Pal Singh , Shradha Singh , Antoine Noujiam , David S. Tam
IPC分类号： C07D339/04
CPC分类号： A61K31/205 , A61K31/385 , A61K47/542 , A61K47/55 , A61K2300/00
摘要： The invention includes novel compounds, including but not limited to formula A and formula B, and an improved delivery method. These compounds and methods are useful in preventing or treating diseases or conditions associated with or caused by the presence of free radicals, and are useful for increasing cellular metabolism while simultaneously alleviating the resultant increase in oxidative stress. Specifically, a carnitine is bound to a lipoic acid derivative or to dihydrolipoic acid or its derivatives using a hydrolysable linker to form a single compound.
摘要翻译： 本发明包括新化合物，包括但不限于式A和式B，以及改进的递送方法。 这些化合物和方法可用于预防或治疗与自由基存在相关或由其引起的疾病或病症，并且可用于增加细胞代谢同时减轻由此导致的氧化应激增加。 具体地，肉碱与硫辛酸衍生物或二氢硫辛酸或其衍生物结合使用可水解接头以形成单一化合物。
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公开(公告)号：US09278340B2
公开(公告)日：2016-03-08
申请号：US13059932
申请日：2009-08-20
申请人： Inder Pal Singh , Shradha Singh , Ritesh Patel , Bharat Mistry , Manish Mehta , Peter Omolo Otieno
发明人： Inder Pal Singh , Shradha Singh , Ritesh Patel , Bharat Mistry , Manish Mehta , Peter Omolo Otieno
IPC分类号： B01J29/06 , B01J23/10 , B01J23/00 , B01J27/26 , B01J29/70 , B01J35/00 , B01J37/00 , B01J37/03 , C07B41/12 , C07C67/03 , C07C67/08 , C10L1/02 , C11C3/00
CPC分类号： C07C67/08 , B01J23/002 , B01J23/10 , B01J27/26 , B01J29/06 , B01J29/072 , B01J29/076 , B01J29/7003 , B01J29/7053 , B01J35/0006 , B01J37/0009 , B01J37/03 , B01J2229/42 , B01J2523/00 , C07B41/12 , C07C67/03 , C10G2300/1011 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C11C3/003 , C11C3/10 , Y02E50/13 , Y02P30/20 , C07C69/52 , C07C69/24 , B01J2523/27 , B01J2523/3706 , B01J2523/23 , B01J2523/31
摘要： Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active.
摘要翻译： 描述了用于将甘油三酯和游离脂肪酸转化为生物柴油的固体混合催化剂和方法。 可以使用间歇或连续方法与用于甘油三酯与烷基醇的酯交换的催化剂以高产率和纯度产生相应的单羧酸酯和甘油。 类似地，烷基和芳基羧酸和游离脂肪酸也被转化为相应的烷基酯。 所描述的催化剂是耐热的，持久的和高活性的。
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公开(公告)号：US20110185625A1
公开(公告)日：2011-08-04
申请号：US13059932
申请日：2009-08-20
申请人： Inder Pal Singh , Shradha Singh , Ritesh Patel , Bharat Mistry , Manish Mehta , Peter Omolo Otieno
发明人： Inder Pal Singh , Shradha Singh , Ritesh Patel , Bharat Mistry , Manish Mehta , Peter Omolo Otieno
CPC分类号： C07C67/08 , B01J23/002 , B01J23/10 , B01J27/26 , B01J29/06 , B01J29/072 , B01J29/076 , B01J29/7003 , B01J29/7053 , B01J35/0006 , B01J37/0009 , B01J37/03 , B01J2229/42 , B01J2523/00 , C07B41/12 , C07C67/03 , C10G2300/1011 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C11C3/003 , C11C3/10 , Y02E50/13 , Y02P30/20 , C07C69/52 , C07C69/24 , B01J2523/27 , B01J2523/3706 , B01J2523/23 , B01J2523/31
摘要： Solid mixed catalysts and methods for use in conversion of triglycerides and free fatty acids to biodiesel are described. A batch or continuous process may be used with the catalysts for transesterification of triglycerides with an alkyl alcohol to produce corresponding mono carboxylic acid esters and glycerol in high yields and purity. Similarly, alkyl and aryl carboxylic acids and free fatty acids are also converted to corresponding alkyl esters. The described catalysts are thermostable, long lasting, and highly active.
摘要翻译： 描述了用于将甘油三酯和游离脂肪酸转化为生物柴油的固体混合催化剂和方法。 可以使用间歇或连续方法与用于甘油三酯与烷基醇的酯交换的催化剂以高产率和纯度产生相应的单羧酸酯和甘油。 类似地，烷基和芳基羧酸和游离脂肪酸也被转化为相应的烷基酯。 所描述的催化剂是耐热的，持久的和高活性的。
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公开(公告)号：US06455702B1
公开(公告)日：2002-09-24
申请号：US09983338
申请日：2001-10-24
申请人： Inder Pal Singh , Shradha Singh
发明人： Inder Pal Singh , Shradha Singh
IPC分类号： C07D23354
CPC分类号： C07D233/54
摘要： A high purity N,N-Carbonyl diimidazole (I) is obtained by the reaction of Imidazole, general formula-II, and bis (trichloromethyl) carbonate. Synthesis of N,N-Carbonyl diimidazole (I) is described:
摘要翻译： 通过咪唑，通式II和碳酸双（三氯甲基）酯的反应获得高纯度N，N-羰基二咪唑（I）。 描述了N，N-羰基二咪唑（I）的合成：
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6.发明申请公开(公告)号：US20110023180A1
公开(公告)日：2011-01-27
申请号：US12838387
申请日：2010-07-16
申请人： Timothy Robert HAWKES , Michael Phillip Langford , Russell Colin Viner , Bernardus Theodorus Maria Vernooij , Richard Dale , Shradha Singh , Vance Kramer
发明人： Timothy Robert HAWKES , Michael Phillip Langford , Russell Colin Viner , Bernardus Theodorus Maria Vernooij , Richard Dale , Shradha Singh , Vance Kramer
IPC分类号： C12N15/82 , C12N9/02 , C07H21/00 , C12N5/10 , A01H5/00 , A01H5/10 , A01N43/40 , A01N43/56 , A01N43/18 , A01N43/80 , A01N33/22 , A01N43/08 , A01P13/00
CPC分类号： C12N9/0069 , A01N41/10 , A01N43/40 , A01N43/80 , C12N9/0004 , C12N9/0073 , C12N15/09 , C12N15/8274 , C12Y113/11027
摘要： Novel hydroxyphenyl pyruvate dioxygenase (HPPD) polypeptides, variants and fragments thereof, as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring HPPD herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for HPPD polypeptides, as well as polynucleotides encoding the same. Methods for the production and use of HPPD herbicide resistant plants that express these novel HPPD polypeptides, methods for selectively controlling weeds in a field at a crop locus, and methods for the assay, characterization, identification and selection of these novel HPPDs are also provided.
摘要翻译： 新型羟基苯基丙酮酸双加氧酶（HPPD）多肽，其变体和片段，以及编码该多肽的多核苷酸，能赋予赋予植物HPPD除草剂抗性或耐受性的商业水平。 组合物包括用于HPPD多肽的氨基酸序列及其变体和片段，以及编码该多肽的多核苷酸。 还提供了用于生产和使用表达这些新型HPPD多肽的HPPD除草剂抗性植物的方法，在作物基因座上选择性控制杂草的方法，以及用于测定，表征，鉴定和选择这些新型HPPD的方法。
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公开(公告)号：US09347046B2
公开(公告)日：2016-05-24
申请号：US12838387
申请日：2010-07-16
申请人： Timothy Robert Hawkes , Michael Phillip Langford , Russell Colin Viner , Bernardus Theodorus Maria Vernooij , Richard Dale , Shradha Singh , Vance Kramer
发明人： Timothy Robert Hawkes , Michael Phillip Langford , Russell Colin Viner , Bernardus Theodorus Maria Vernooij , Richard Dale , Shradha Singh , Vance Kramer
IPC分类号： A01H5/00 , A01H5/10 , C12N15/01 , C12N15/82 , C12N15/63 , C12N9/02 , C12N15/29 , A01N25/00 , C12N15/09
CPC分类号： C12N9/0069 , A01N41/10 , A01N43/40 , A01N43/80 , C12N9/0004 , C12N9/0073 , C12N15/09 , C12N15/8274 , C12Y113/11027
摘要： Novel hydroxyphenyl pyruvate dioxygenase (HPPD) polypeptides, variants and fragments thereof, as well as polynucleotides encoding the same, capable of conferring commercial levels of conferring HPPD herbicide resistance or tolerance to plants. Compositions include amino acid sequences, and variants and fragments thereof, for HPPD polypeptides, as well as polynucleotides encoding the same. Methods for the production and use of HPPD herbicide resistant plants that express these novel HPPD polypeptides, methods for selectively controlling weeds in a field at a crop locus, and methods for the assay, characterization, identification and selection of these novel HPPDs are also provided.
摘要翻译： 新型羟基苯基丙酮酸双加氧酶（HPPD）多肽，其变体和片段，以及编码该多肽的多核苷酸，能赋予赋予植物HPPD除草剂抗性或耐受性的商业水平。 组合物包括用于HPPD多肽的氨基酸序列及其变体和片段，以及编码该多肽的多核苷酸。 还提供了用于生产和使用表达这些新型HPPD多肽的HPPD除草剂抗性植物的方法，在作物基因座上选择性控制杂草的方法，以及用于测定，表征，鉴定和选择这些新型HPPD的方法。
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