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1.发明授权Cytotoxic T-cell epitopes of the papillomavirus L1-protein and use thereof in diagnostics and therapy 失效乳头瘤病毒L1蛋白的细胞毒性T细胞表位及其在诊断和治疗中的用途公开(公告)号：US06911207B1
公开(公告)日：2005-06-28
申请号：US09980064
申请日：2000-05-31
申请人： Ingrid Jochmus , John Nieland , Wolfram Osen , Stefan Faath , Klaus Schäfer
发明人： Ingrid Jochmus , John Nieland , Wolfram Osen , Stefan Faath , Klaus Schäfer
IPC分类号： G01N33/569 , A61K35/00 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/39 , A61K48/00 , A61P37/04 , C07K14/025 , C07K14/47 , C12N5/10 , C12N5/22 , C12N15/09 , C12N15/37 , C12Q1/02 , C12Q1/68
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20022
摘要： The present invention relates to a papillomavirus T-cell epitope having an amino acid sequence AQIFNKPYW, AGVDNRECI and/or to a functionally active variant thereof, also to their use in diagnostics and therapy.
摘要翻译： 本发明涉及具有氨基酸序列AQIFNKPYW，AGVDNRECI和/或其功能活性变体的乳头瘤病毒T细胞表位，也用于其在诊断和治疗中的用途。
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2.发明授权Cytotoxic T-cell epitopes of the papilloma virus l1-protein and use thereof in diagnosis and therapy 失效乳头状瘤病毒11蛋白的细胞毒性T细胞表位及其在诊断和治疗中的用途公开(公告)号：US06838084B1
公开(公告)日：2005-01-04
申请号：US09980177
申请日：2000-05-31
申请人： Ingrid Jochmus , John Nieland
发明人： Ingrid Jochmus , John Nieland
IPC分类号： C12N15/09 , A61K9/08 , A61K35/76 , A61K38/00 , A61K39/00 , A61K45/00 , A61K47/46 , A61P31/12 , C07K14/025 , C12N5/10 , C12N7/04 , C12Q1/02 , A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20022
摘要： The present invention relates to a papillomavirus T-cell epitope having an amino acid sequence ILVPKVSGL (SEQ ID NO: 1), RLVWACVGV (SEQ ID NO: 2), HLFNRAGTV (SEQ ID NO: 3), YLRREQMFV (SEQ ID NO: 4), TLQANKSEV (SEQ ID NO: 5), ILEDWNFGL (SEQ ID NO: 6), SLWLPSEATVYL (SEQ ID NO: 7), NLASSNYFPT (SEQ ID NO: 8), TLTADVMTYI (SEQ ID NO: 9), YLPPVPSKV (SEQ ID NO: 10), YDLQFIFQL (SEQ ID NO: 11), ICWGNQLFV (SEQ ID NO: 12), FYNPDTQRL (SEQ ID NO: 13), MHGDTPTLH (SEQ ID NO: 14), ETTDLYCY (SEQ ID NO: 15), QAEPDRAHYN (SEQ ID NO: 16), SMVTSDAQI (SEQ ID NO: 17), and/or to a functionally active variant thereof, and also to their use in diagnostics and therapy.
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公开(公告)号：US20050085433A1
公开(公告)日：2005-04-21
申请号：US10494716
申请日：2002-11-08
申请人： Claudia Breidenstein , John Nieland
发明人： Claudia Breidenstein , John Nieland
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/57
摘要： The invention relates to a composition for vaccination against tumors containing at least one tumor cell, which expresses at least one cytikine, chemokine and/or a con-stimulating molecule and an effective quantity of at least one adjuvant. The invention also relates to the used of a composition of this type for a producing a medicament for the treatment or prevention of tumors.
摘要翻译： 本发明涉及用于接种肿瘤的组合物，该组合物含有至少一种肿瘤细胞，其表达至少一种细胞因子，趋化因子和/或促刺激分子和有效量的至少一种佐剂。 本发明还涉及用于产生用于治疗或预防肿瘤的药物的这种类型的组合物。
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公开(公告)号：US20090143276A1
公开(公告)日：2009-06-04
申请号：US12247897
申请日：2008-10-08
CPC分类号： C07K14/4713 , C07K14/4726 , C07K14/545 , C07K2319/31 , C12N15/62
摘要： Interleuekin-1 receptor antagonists (IL-1Ra) including fusion proteins having a trimerizing domain and an IL-1Ra polypeptide sequence. The fusion proteins are part of trimeric complexes that are used in pharmaceutical compositions for treating diseases mediated by IL-1. Effective treatment of inflammatory diseases, such as rheumatoid arthritis and diabetes, are described.
摘要翻译： Interleuekin-1受体拮抗剂（IL-1Ra）包括具有三聚结构域和IL-1Ra多肽序列的融合蛋白。 融合蛋白是用于治疗由IL-1介导的疾病的药物组合物中的三聚体复合物的一部分。 描述了炎症性疾病如类风湿性关节炎和糖尿病的有效治疗。
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5.发明申请Topical use of cytokines and chemokines for the treatment of viral or mykotic skin diseases or tumoral diseases 审中-公开细胞因子和趋化因子的局部用途用于治疗病毒性或肌肉病性皮肤病或肿瘤性疾病公开(公告)号：US20050008614A1
公开(公告)日：2005-01-13
申请号：US10493884
申请日：2002-11-07
申请人： John Nieland , Christoph Rehfuess
发明人： John Nieland , Christoph Rehfuess
IPC分类号： A61K9/06 , A61K9/00 , A61K9/12 , A61K38/00 , A61K38/19 , A61K38/21 , A61K47/00 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K47/44 , A61P17/00 , A61P31/10 , A61P31/12 , A61P35/00
CPC分类号： A61K9/0014 , A61K38/063 , A61K38/193 , A61K38/385 , A61K47/06 , A61K47/10 , A61K47/20 , A61K47/28 , A61K2300/00
摘要： The invention relates to the use of at least one cytokine and/or chemokine in the production of a topically acting medicament for treating viral and/or mykotic skin diseases and/or tumoral diseases.
摘要翻译： 本发明涉及至少一种细胞因子和/或趋化因子在制备用于治疗病毒和/或肌肉病皮肤疾病和/或肿瘤性疾病的局部作用药物中的用途。
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公开(公告)号：US20060089406A1
公开(公告)日：2006-04-27
申请号：US10528308
申请日：2003-09-18
IPC分类号： A61K31/336
CPC分类号： A61K31/336
摘要： The invention relates to a method of preventing and/or treating a chronic and/or an atopic skin disease by administering an inhibitor of fatty acid oxidation to a patient in a pharmacologically effective amount. Furthermore, the invention relates to the use of at least one inhibitor of fatty acid oxidation for the preparation of a pharmaceutical composition for the prophylaxis and/or treatment of a chronic and/or an atopic skin disease.
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7.发明申请Allogenic vaccine that contains a costimulatory polypeptide-expresing tumor cell 审中-公开含有共刺激多肽表达肿瘤细胞的同种异体疫苗公开(公告)号：US20050025789A1
公开(公告)日：2005-02-03
申请号：US10494715
申请日：2002-11-08
申请人： John Nieland , Claudia Breidenstein , Ute Sartorius , Ulrich Moebius , Christoph Bogedain , Adelheid Dinkel
发明人： John Nieland , Claudia Breidenstein , Ute Sartorius , Ulrich Moebius , Christoph Bogedain , Adelheid Dinkel
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/57
摘要： The invention relates to the use of a tumor cell for producing a vaccine for the treatment or prophylaxis of tumors in patients, said tumor cell expressing a costimulatory polypeptide and said tumor cell and said patient having non-identical MHC molecules. The invention further relates to the use of a costimulatory polypeptide-expressing tumor cell for producing a vaccine for increasing the lytic activity of NK cells in the treatment or prophylaxis of a tumor in a patient that is allogenic with respect to the tumor cell.
摘要翻译： 本发明涉及肿瘤细胞在制备用于治疗或预防患者肿瘤的疫苗中的用途，所述肿瘤细胞表达共刺激多肽和所述肿瘤细胞，所述患者具有不相同的MHC分子。 本发明还涉及一种表达共刺激多肽的肿瘤细胞用于产生用于增加NK细胞裂解活性的疫苗在治疗或预防相对于肿瘤细胞同种异体的患者中的肿瘤的用途。
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公开(公告)号：US20100203083A1
公开(公告)日：2010-08-12
申请号：US12601651
申请日：2008-06-02
申请人： Kerstin Lux , Hildegard Buening , Luca Perabo , John Nieland , Jorge Boucas , Michael Hallek , Mirko Ritter , Markus Hoerer
发明人： Kerstin Lux , Hildegard Buening , Luca Perabo , John Nieland , Jorge Boucas , Michael Hallek , Mirko Ritter , Markus Hoerer
IPC分类号： A61K39/23 , C07K14/015 , C07H21/04 , C12N15/63 , C12N7/04 , A61K38/16 , A61K31/7088 , A61P37/00 , A61P35/04 , A61P25/28 , A61P31/00
CPC分类号： C07K14/015 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C07K2319/40 , C12N7/00 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145 , C12N2810/405
摘要： The present invention is related to a structural protein of a parvovirus with an amino acid insertion at the insertion site I-453, a library comprising the protein, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a vector, virus or cell comprising the nucleic acid, a process for the preparation of the protein, a medicament comprising the protein, nucleic acid or multimeric structure as well as methods and uses involving the protein, nucleic acid or multimeric structure.
摘要翻译： 本发明涉及在插入位点I-453处具有氨基酸插入的细小病毒的结构蛋白质，包含该蛋白质的文库，包含该蛋白质的多聚体结构，编码该蛋白质的核酸，载体，病毒或 包含核酸的细胞，制备蛋白质的方法，包含蛋白质，核酸或多聚体结构的药物以及涉及蛋白质，核酸或多聚体结构的方法和用途。
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公开(公告)号：US20100297177A1
公开(公告)日：2010-11-25
申请号：US12601639
申请日：2008-06-02
申请人： Hildegard Buening , John Nieland , Luca Perabo , Daniela Kuehn , Kerstin Lux , Michael Hallek , Markus Hoerer , Mirko Ritter
发明人： Hildegard Buening , John Nieland , Luca Perabo , Daniela Kuehn , Kerstin Lux , Michael Hallek , Markus Hoerer , Mirko Ritter
IPC分类号： A61K39/23 , C40B30/04 , C07K14/00 , C07H21/04 , C12N7/01 , C12P21/00 , A61K38/00 , A61P37/04
CPC分类号： G01N33/56983 , A61K39/00 , A61K2039/5256 , C07K14/005 , C07K16/081 , C07K16/4291 , C07K2317/34 , C07K2317/76 , C12N2750/14122 , C12N2750/14143 , G01N2333/015 , G01N2500/04
摘要： The present invention is related to a method for identifying a parvovirus mutated structural protein capable of specifically binding to a binder for an antigen, a parvovirus mutated structural protein which comprises at least one B-cell epitope heterologous to the parvovirus, a multimeric structure comprising the protein, a nucleic acid encoding the protein, a virus or cell comprising the protein, a method of preparing the protein, a medicament comprising the protein, nucleic acid or multimeric structure and its use.
摘要翻译： 本发明涉及用于鉴定能够特异性结合抗原的粘合剂的细小病毒突变结构蛋白的方法，包括至少一个与细小病毒异源的B细胞表位的细小病毒突变的结构蛋白，包含 蛋白质，编码蛋白质的核酸，包含蛋白质的病毒或细胞，制备蛋白质的方法，包含蛋白质，核酸或多聚体结构的药物及其用途。
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公开(公告)号：US20100028995A1
公开(公告)日：2010-02-04
申请号：US12420680
申请日：2009-04-08
申请人： Jonas Heilskov Graversen , Hans Christian Thøgersen , Anke Kretz-Rommel , Michael Etzerodt , Thor Las Holtet , Mikkel Holmen Andersen , John Nieland
发明人： Jonas Heilskov Graversen , Hans Christian Thøgersen , Anke Kretz-Rommel , Michael Etzerodt , Thor Las Holtet , Mikkel Holmen Andersen , John Nieland
CPC分类号： C07K14/4726 , A61K38/16
摘要： Tetranectin trimerizing polypeptides and fusion proteins including the polypeptides and therapeutic polypeptides and proteins. Trimeric complexes of the polypeptides and fusion proteins. Pharmaceutical compositions of the polypeptides, fusion proteins and the trimeric complexes.
摘要翻译： 拓扑结核三聚体多肽和融合蛋白，包括多肽和治疗性多肽和蛋白质。 多肽和融合蛋白的三聚体复合物。 多肽，融合蛋白和三聚体复合物的药物组合物。
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