Method for the determination of albumin in biological fluids
    2.
    发明授权
    Method for the determination of albumin in biological fluids 失效
    生物体液中白蛋白测定方法

    公开(公告)号:US5110746A

    公开(公告)日:1992-05-05

    申请号:US299939

    申请日:1988-12-22

    IPC分类号: G01N33/68

    CPC分类号: G01N33/6827

    摘要: Serum is reacted with a dinitrohalobenzene compound and the rate of halogen formation is measured. This rate is in proportion to the amount of albumin in the sample. Other proteins like the globulins, as well as free aminoacids and urea, do not interfere with this reaction.

    摘要翻译: PCT No.PCT / US88 / 01328 Sec。 371日期:1988年12月22日 102(e)日期1988年12月22日PCT提交1988年4月22日PCT公布。 第WO88 / 08533号公报 日期:1988年11月3日。与二硝基卤代苯化合物反应,测定卤素形成速率。 该比例与样品中白蛋白的量成比例。 其他蛋白质,如球蛋白,以及游离氨基酸和尿素,都不会干扰该反应。

    Analytical method of determining a reduced co-enzyme
    6.
    发明授权
    Analytical method of determining a reduced co-enzyme 失效
    确定还原型辅酶的分析方法

    公开(公告)号:US4956276A

    公开(公告)日:1990-09-11

    申请号:US939123

    申请日:1986-11-13

    摘要: The sample for analysis containing the co-enzyme to be detemined, inter alia NADH or NADPH, is placed in the presence of a fluorinated aromatic compound. In the presence of oxygen and peroxidase, the fluorinated compound releases fluoride ions at a rate proportional to the quantity of co-enzyme to be determined. The thus-formed F.sup.- ions are determined, thus obtaining the desired result.

    摘要翻译: PCT No.PCT / CH86 / 00032 Sec。 371日期:1986年11月13日 102(e)1986年11月13日PCT PCT公布1986年3月10日PCT公布。 出版物WO86 / 05517 日期为1986年9月25日。含有待测定的辅酶(包括NADH或NADPH)的分析样品置于含氟芳族化合物的存在下。 在氧和过氧化物酶的存在下,氟化化合物以与待测量的辅酶的量成比例的比例释放氟离子。 确定如此形成的F离子,从而获得所需的结果。

    Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging
    9.
    发明申请
    Reconstitutable formulation and aqueous suspension of gas-filled microvesicles for diagnostic imaging 审中-公开
    用于诊断成像的气体填充微泡的可重构制剂和水悬浮液

    公开(公告)号:US20050025710A1

    公开(公告)日:2005-02-03

    申请号:US10630375

    申请日:2003-07-29

    IPC分类号: A61K49/18 A61K49/22 A61K49/00

    CPC分类号: A61K49/1815 A61K49/225

    摘要: The invention relates to a formulation comprising a dry material (e.g. lyophilised or spray dried) comprising at least one film forming surfactant and a gas or a gas mixture usable in diagnostic imaging, to a process for the preparation thereof and to a suspension obtainable by reconstituting said formulation with an aqueous carrier for use in contrast imaging. The invention also relates to a container comprising the dry material in contact with a gas. The gas associated with the dry material is at a pressure lower than the atmospheric pressure.

    摘要翻译: 本发明涉及包含干物质(例如冻干或喷雾干燥的)的制剂,其包含至少一种成膜表面活性剂和可用于诊断成像的气体或气体混合物,其制备方法和可通过重构获得的悬浮液 所述制剂具有用于对比成像的水性载体。 本发明还涉及包含与气体接触的干燥材料的容器。 与干燥材料相关联的气体处于低于大气压的压力。

    Method of storing frozen microbubble suspensions
    10.
    发明授权
    Method of storing frozen microbubble suspensions 失效
    储存冷冻微泡悬浮液的方法

    公开(公告)号:US5830435A

    公开(公告)日:1998-11-03

    申请号:US909100

    申请日:1997-08-12

    CPC分类号: A61K49/223

    摘要: Disclosed are suspensions of gas microbubbles immobilised within a frozen aqueous carrier liquid comprising usual additives and stabilisers, in which the carrier liquid is a physiologically acceptable, the immobilised gas microbubbles are microbubbles bound by an evanescent envelope or a tangible membrane. The suspensions, when in liquid form, are injectable and useful as a contrast agents in ultrasonic imaging of blood pool and tissue of living beings. The gas microbubbles are immobilised within the carrier by freezing a suspension of microbubbles with average sizes below 50 .mu.m, preferably below 10 .mu.m and more preferably between 2 .mu.m and 8 .mu.m, to a temperature between -1.degree. C. and -76.degree. C. and maintaining this temperature for prolonged periods of time. The microbubbles may be stabilised by a surfactant such as a lamellar phospholipid or may comprise a membrane made of synthetic or natural polymer or protein. A method of cold storage of microbubble suspensions as well as their use is also disclosed.

    摘要翻译: 公开了固定在包含通常的添加剂和稳定剂的冷冻含水载体液体中的气体微泡的悬浮液,其中载体液体是生理上可接受的,固定化气体微泡是由ev逝包膜或有形膜结合的微泡。 当液体形式时,悬浮液是可注射的,并且可用作血液池和生物组织的超声成像中的造影剂。 将气体微泡固定在载体中,将平均尺寸低于50μm,优选低于10μm,更优选在2μm和8μm之间的微泡悬浮液冷冻至-1℃至-1℃的温度, 76℃,并保持该温度较长时间。 微泡可以通过表面活性剂如片状磷脂来稳定,或者可以包含由合成或天然聚合物或蛋白质制成的膜。 还公开了微泡悬浮液的冷藏方法及其用途。