摘要:
The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
摘要:
The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
摘要:
A snow sled for use by a seated rider is disclosed and includes a body section, a seat section having an underside for engaging the snow and a top side for receiving the seated rider, the seat section attached to the body section, a foot section having an underside for engaging the snow and positioned forward of the seat section when the snow sled is deployed in the riding configuration and positioned adjacent the seat section when the snow sled is retracted into the stowable configuration, and a handlebar arrangement connecting the body section to the foot section.
摘要:
A game apparatus for catching and throwing a projectile. The apparatus includes a handle, and a basket attached to the handle for catching and throwing the projectile. The basket includes spaced apart retaining members configured to yield sufficiently to allow the projectile to pass between them when the projectile is received during a catch, and further configured to retain the projectile after the catch. The basket portion also includes a support structure configured to support the projectile after the projectile passes between the retaining members. A primary aperture is disposed at an end of the basket portion substantially opposite the handle, and is dimensioned to allow the projectile to pass through and exit the basket during a throw.
摘要:
A target-specific, cytotoxic, recombinant Pseudomonas exotoxin is described. Such toxins are made by inserting specific recognition molecules at specific cloning sites in at least domain III near the carboxyl terminus of the PE molecule. Various modifications of the carboxyl terminus of the PE molecule to increase cytotoxicity are set forth. Multifunctional, recombinant, cytotoxic fusion proteins containing at least two different recognition molecules are provided for killing cells expressing receptors to which the recognition molecules bind with specificity. Methods for producing novel recombinant PE molecules with specific properties are described.
摘要:
A patient claim data processing system responds to and initiates clinical events and attains early accurate claim data during a patient healthcare encounter cycle to support prompt claim data validation and editing both for individual claim elements and for a completed claim to improve claim accuracy prior to claim submission to a payer. The system submits accurate claims to payers and receives remittance advice from payers and applies rules to the advice. A system processes financial data related to provision of healthcare to a patient in response to clinical events. The system includes an interface processor for receiving a message identifying an event and a related change in healthcare data concerning a patient and also includes a source of rules for determining characteristics associated with reimbursement for provision of an individual service to a patient. A rules processor initiates application of a rule derived from the rules source to process financial data concerning provision of the individual service to the patient in response to receiving the message identifying the event. A result processor initiates an action in response to a result derived by the application of the rule to process the financial data. The rules processor also validates the financial data complies with the rule.
摘要:
A snow recreation device is provided. The device is defined by a convex bottom surface that includes tracking and steering ridges. In some embodiments, the device includes raised handles configured to position a rider's grip above the bottom surface of the device.
摘要:
A recording system employing a magneto-resistive (MR) element senses a resistance value of the MR element and generates one or more MR resistance (MRR) signal values based on the sensed MR element resistance value. The MRR signal values might be, for example, current or voltage values proportional or inversely proportional to the MR element resistance value. The MRR signal values might be employed to control one or more of: i) a unity gain bandwidth of a bias loop for the MR element, ii) an MR read head preamplifier low corner frequency, and iii) a slew rate across the MR element.
摘要:
This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.