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1.发明申请Biological Bypass Bridge with Sodium Channels, Calcium Channels and/or Potassium Channels to Compensate for Conduction Block in the Heart 审中-公开具有钠通道，钙通道和/或钾通道的生物旁路桥，用于补偿心脏中的传导阻滞公开(公告)号：US20130110218A1
公开(公告)日：2013-05-02
申请号：US13535013
申请日：2012-06-27
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译： 本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气 在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。 本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。
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2.发明申请公开(公告)号：US20110223144A1
公开(公告)日：2011-09-15
申请号：US13109804
申请日：2011-05-17
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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3.发明授权公开(公告)号：US07968126B2
公开(公告)日：2011-06-28
申请号：US10584303
申请日：2004-12-22
CPC分类号： A61L27/3873 , A61L27/3834 , A61L27/3895 , C12N5/0663 , C12N2502/1329
摘要： A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle.
摘要翻译： 为心脏产生房室旁路的方法包括将间充质干细胞生长成具有两端的条带，将条带的一端附接到心脏的心房上，并将带的另一端附接到心脏的心室 ，以产生将心房连接到心室的路径，以提供由窦房结产生的电信号通过道路传播并激发心室的路径。
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公开(公告)号：US20100189701A1
公开(公告)日：2010-07-29
申请号：US12520804
申请日：2007-12-26
申请人： Ira S Cohen , Peter R. Brink , Michael R. Rosen , Richard B. Robinson , Peter Danilo, JR. , Heather S. Duffy
发明人： Ira S Cohen , Peter R. Brink , Michael R. Rosen , Richard B. Robinson , Peter Danilo, JR. , Heather S. Duffy
IPC分类号： A61K35/12 , A61K31/7088 , A61K31/5377
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0375 , A61K49/0008 , C07K14/705 , C12N15/1138 , C12N2310/14
摘要： The present invention provides compositions and methods of treatment for atrial fibrillation and ventricular tachycardia. The compositions are useful for modifying the conducting properties of heart tissues in which impulses are generating and/or are useful for altering refractoriness without prolonging repolarization.
摘要翻译： 本发明提供了治疗房颤和室性心动过速的组合物和方法。 组合物可用于改变其中产生脉冲的心脏组织的导电性质和/或可用于改变耐火性而不延长复极度。
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5.发明授权Biological bypass bridge with sodium channels, calcium channels and/or potassium channels to compensate for conduction block in the heart 有权具有钠通道，钙通道和/或钾通道的生物旁路桥以补偿心脏中的传导阻滞公开(公告)号：US08236296B2
公开(公告)日：2012-08-07
申请号：US11490760
申请日：2006-07-21
CPC分类号： A61N1/0587 , C12N5/0663 , C12N2502/1329 , C12N2510/00
摘要： This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
摘要翻译： 本发明提供了一种旁路桥，其包括一段具有第一端和第二端的间隙连接耦合的电池，两端能够连接到心脏中的两个选定位置，以允许起搏器和/或电气 在两个位点之间的通道之间的信号/电流，其中细胞在功能上表达钠通道。 本发明还提供了制造旁路桥的相关方法，在心脏中植入其的方法，以及治疗与受试者心脏中的传导受损有关的障碍的方法。
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6.发明授权公开(公告)号：US08170665B2
公开(公告)日：2012-05-01
申请号：US12077970
申请日：2008-03-21
申请人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
发明人： Ira S. Cohen , Amy B. Rosen , Peter R. Brink , Glenn Gaudette , Michael R. Rosen , Richard B. Robinson
IPC分类号： A61N1/00
CPC分类号： G01N33/588 , A61K35/12 , A61N1/372 , B82Y15/00 , C12N5/0663 , C12N2510/00 , G01N33/6872 , G01N2333/705
摘要： The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been genetically engineered to express, for example, a hyperpolarization-activated cyclic nucleotide-gated (“HCN”) channel and administered to a subject to create a biological pacemaker. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host.
摘要翻译： 本发明提供了与称为量子点（QD）的纳米尺度荧光半导体标记靶细胞有关的方法和组合物。 具体地，基于使用带负电荷的量子点，通过被动内吞作用介导的递送过程将跟踪荧光信号传递到靶细胞的胞质溶胶中，公开了递送系统。 在本发明的具体实施方案中，靶细胞是干细胞，优选间充质干细胞（MSC）。 这种标记的MSC提供了用于跟踪已经被遗传工程化以表达例如超极化激活的环核苷酸门控（“HCN”）信道并且施用于受试者以创建生物起搏器的MSC的分布和命运的手段。 本发明基于这样的发现，MSC可以在体外追踪长达至少6周。 另外，在体内交付的量测数据可以跟踪至少8周，从而允许在管理到主机之后，所有MSC的位置的完整三维重构。
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7.发明授权Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA 有权通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统公开(公告)号：US07842673B2
公开(公告)日：2010-11-30
申请号：US10583369
申请日：2004-12-17
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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公开(公告)号：US20090053180A1
公开(公告)日：2009-02-26
申请号：US11490997
申请日：2006-07-21
申请人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
发明人： Michael R. Rosen , Peter R. Brink , Richard B. Robinson , Ira S. Cohen , Steven Girouard , Bruce Kenknight
CPC分类号： A61N1/372 , C12N5/0657 , C12N2502/1329 , C12N2502/1358 , C12N2510/00
摘要： This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.
摘要翻译： 本发明提供了起搏器系统，其包括（1）电子起搏器和（2）生物起搏器，其中生物起搏器包括功能性地表达嵌合超极化激活的环核苷酸门控（HCN）离子通道的细胞，其水平有效 在细胞中诱导起搏器电流。 本发明还提供了相关的生物起搏器，房室桥梁，其制造方法以及治疗患有心律失常的受试者的方法。
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9.发明申请Delivery of DNA or RNA via gap junctions from host cells to target cells and a cell-based delivery system for antisense or siRNA 有权通过从宿主细胞到靶细胞的间隙连接递送DNA或RNA，以及用于反义或siRNA的基于细胞的递送系统公开(公告)号：US20110076773A1
公开(公告)日：2011-03-31
申请号：US12910346
申请日：2010-10-22
CPC分类号： A61K48/0083 , C12N15/87
摘要： A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell.
摘要翻译： 将寡核苷酸或表达寡核苷酸的质粒递送到靶细胞的方法包括将寡核苷酸引入供体细胞，特别是干细胞，并在允许供体细胞形成间隙连接的条件下使靶细胞与供体细胞接触 与靶细胞接触，由此寡核苷酸或寡核苷酸的产物从供体细胞输送到靶细胞中。
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公开(公告)号：US20110041857A1
公开(公告)日：2011-02-24
申请号：US12744568
申请日：2008-11-26
申请人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
发明人： Adam J.T. Schuldt , Peter R. Brink , Ira S. Cohen , Michael R. Rosen , Richard B. Robinson , Glenn Gaudette
CPC分类号： C12N5/0662 , C12N5/0657 , C12N2506/1307 , C12N2533/32
摘要： The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions.
摘要翻译： 本发明提供了与衍生于去分化成纤维细胞的干细胞的生产有关的方法和组合物，以及这些干细胞用于治疗各种不同疾病和病症的用途。 本发明基于令人惊奇的发现，即可以通过在选择性培养条件下培养成纤维细胞来产生能够分化成多种不同细胞类型的干细胞群体。
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