-
公开(公告)号：US09952148B2
公开(公告)日：2018-04-24
申请号：US12867383
申请日：2009-02-19
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
-
公开(公告)号：US20110109910A1
公开(公告)日：2011-05-12
申请号：US12867383
申请日：2009-02-19
IPC分类号： G01N21/47
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
摘要翻译： 在一个方面，本发明通常提供用于通过用辐射照射材料来表征材料（例如生物材料）的矿化的方法，并且响应于照明分析从材料散射的辐射。 例如，在一些实施例中，可以以多个波长的偏振辐射照射材料，并且对应于这些波长中的两个或更多个的弹性散射辐射可以以两个极化收集：一个平行且另一个垂直于照明偏振 。 可以分析两个极化处的散射辐射的差分强度作为波长的函数，以获得关于样品中矿物沉积物形态的信息。 此外，可以分析总散射辐射以得到关于矿化水平的信息。
-
公开(公告)号：US20100063404A1
公开(公告)日：2010-03-11
申请号：US12513387
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical waveguide includes providing a biopolymer, unwinding the biopolymer progressively to extract individual biopolymer fibers, and putting the unwound fibers under tension. The tensioned fibers are then cast in a different polymer to form a biopolymer optical waveguide that guides light due to the difference in indices of refraction between the biopolymer and the different polymer. The optical fibers may be used in biomedical applications and can be inserted in the body as transmissive media. Printing techniques may be used to manufacture the biopolymer optical waveguides.
摘要翻译： 制造生物聚合物光波导的方法包括提供生物聚合物，逐渐解卷生物聚合物以提取单个生物聚合物纤维，以及将展开的纤维置于张力下。 然后将张紧的纤维浇铸在不同的聚合物中以形成由于生物聚合物和不同聚合物之间的折射率差异而引导光的生物聚合物光波导。 光纤可以用于生物医学应用，并且可以作为透射介质插入体内。 印刷技术可用于制造生物聚合物光波导。
-
公开(公告)号：US20100096763A1
公开(公告)日：2010-04-22
申请号：US12513423
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.
摘要翻译： 一种制备生物聚合物光流体装置的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将生物聚合物基质溶液浇铸在基材上，将通道模具嵌入生物聚合物基质溶液中，干燥生物聚合物基质 固化生物聚合物光流体装置的解决方案，以及提取嵌入式通道模具以在凝固的生物聚合物光流体装置中提供流体通道。 根据另一方面，提供了由生物聚合物制成并且在其中具有用于输送流体的通道的光流体装置。
-
5.发明申请MICROFLUIDIC DEVICE WITH A CYLINDRICAL MICROCHANNEL AND A METHOD FOR FABRICATING SAME 审中-公开具有圆柱微通道的微流体装置及其制造方法公开(公告)号：US20100068740A1
公开(公告)日：2010-03-18
申请号：US12513416
申请日：2007-11-05
申请人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
发明人： David L. Kaplan , Fiorenzo Omenetto , Brian Lawrence , Mark Cronin-Golomb , Irene Georgakoudi , Hannah Perry
CPC分类号： B29D11/0074 , B01L3/502707 , B01L2300/0816 , B01L2300/12 , B01L2300/163 , B29C39/02 , B81B2201/058 , B81B2201/06 , B81C1/00071 , G01J3/02 , G01J3/0237 , G01J3/0256 , G01J3/06 , G01J3/10 , G01J3/1804 , G01J3/42 , G01N33/54386 , G01N2021/0346
摘要： A method of manufacturing a microfluidic device having at least one cylindrical microchannel includes providing a substrate, casting an uncured polymer matrix solution onto the substrate, embedding an elongated rod in the uncured polymer matrix solution, curing the polymer matrix solution to form a solidified body, and extracting the elongated rod to form the cylindrical microchannel in the solidified body. In another embodiment, the method includes forming an optical feature on a surface of the microfluidic device. A microfluidic device is also provided, the device including a polymer body, and at least one cylindrical microchannel in the polymer body, the cylindrical microchannel having a diameter between approximately 40 ?m and 250 ?m, inclusive. An additional microfluidic device is provided that functions as an optofluidic spectrometer. The optofluidic spectrometer includes a polymer body, a diffraction grating integrated within the polymer body, and a cylindrical microchannel behind the diffraction grating on the polymer body.
摘要翻译： 制造具有至少一个圆柱形微通道的微流体装置的方法包括提供基底，将未固化的聚合物基质溶液浇铸到基底上，将细长棒嵌入未固化的聚合物基质溶液中，固化聚合物基质溶液以形成凝固体， 并提取细长杆以在凝固体中形成圆柱形微通道。 在另一个实施例中，该方法包括在微流体装置的表面上形成光学特征。 还提供了一种微流体装置，该装置包括聚合物主体和聚合物主体中的至少一个圆柱形微通道，所述圆柱形微通道的直径在约40μm至250μm之间，包括端点在内。 提供额外的微流体装置，其用作光流体光谱仪。 光流体光谱仪包括聚合物体，集成在聚合物主体内的衍射光栅，以及聚合物主体上的衍射光栅后面的圆柱形微通道。
-
6.发明申请公开(公告)号：US20100120116A1
公开(公告)日：2010-05-13
申请号：US12513394
申请日：2007-11-05
摘要： A method of manufacturing a nanopatterned biopolymer optical device includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate with a nanopatterned surface, casting the biopolymer matrix solution on the nanopatterned surface of the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film on the substrate, where the solidified biopolymer film is formed with a surface having a nanopattern thereon. In another embodiment, the method also includes annealing the solidified biopolymer film. A nanopatterned biopolymer optical device includes a solidified biopolymer film with a surface having a nanopattern is also provided.
摘要翻译： 制备纳米图案生物聚合物光学器件的方法包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，向基质提供纳米图案化的表面，将生物聚合物基质溶液浇铸在基底的纳米图案化表面上，并干燥生物聚合物基质 溶液以在基底上形成固化的生物聚合物膜，其中固化的生物聚合物膜形成有其上具有纳米图案的表面。 在另一个实施方案中，该方法还包括退火固化的生物聚合物膜。 还提供了纳米图案生物聚合物光学装置，其包括具有具有纳米图案的表面的固化的生物聚合物膜。
-
公开(公告)号：US20100046902A1
公开(公告)日：2010-02-25
申请号：US12513384
申请日：2007-11-05
CPC分类号： G02B1/005 , B29D11/00 , B82Y20/00 , G02B6/1225 , Y10T428/24273 , Y10T428/24355 , Y10T428/31678
摘要： A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.
摘要翻译： 制备生物聚合物光子晶体的方法包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将基质溶液浇铸在基材上，以及干燥生物聚合物基质溶液以形成固化的生物聚合物膜。 膜的表面形成有纳米图案，或者在膜的表面上加工纳米图案。 在另一个实施方案中，多个生物聚合物膜堆叠在一起。 还提供了由生物聚合物制成并具有纳米图案表面的光子晶体。 在另一个实施例中，光子晶体包括堆叠在一起的多个纳米图案化膜。
-
公开(公告)号：US08529835B2
公开(公告)日：2013-09-10
申请号：US12513441
申请日：2007-11-05
IPC分类号： C12Q1/68
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译： 一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥 在基材上形成凝固的生物聚合物传感器。 还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。
-
公开(公告)号：US20100070068A1
公开(公告)日：2010-03-18
申请号：US12513441
申请日：2007-11-05
IPC分类号： G06F19/00
CPC分类号： B29D11/0074 , B29C41/02
摘要： A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material.
摘要翻译： 一种制备生物聚合物传感器的方法，包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，在生物聚合物基质中添加生物材料，提供基材，将基质溶液浇铸在基材上，并将生物聚合物基质溶液干燥 在基材上形成凝固的生物聚合物传感器。 还提供了一种生物聚合物传感器，其包括具有嵌入的生物材料的固化的生物聚合物膜。
-
10.发明申请公开(公告)号：US20100065784A1
公开(公告)日：2010-03-18
申请号：US12513392
申请日：2007-11-05
CPC分类号： C07K14/43586 , B29C39/02 , B29D11/00663 , B29D11/0074 , B82Y20/00 , D01F4/02 , D10B2211/04 , D10B2401/20 , G01N33/5436 , G01N33/54373 , G01N33/54386 , G01N33/544 , G01N2333/43578 , G02B1/005 , G02B1/04 , G02B1/041 , G02B1/045 , G02B1/046 , G02B1/06 , G02B5/18 , G02B6/138 , G02B2006/12102 , G02B2006/12104 , G02B2006/12107 , G02B2006/1213 , G02B2006/12171
摘要： A method of manufacturing a biopolymer optical device includes providing a polymer, providing a substrate, casting the polymer on the substrate, and enzymatically polymerizing an organic compound to generate a conducting polymer between the provided polymer and the substrate. The polymer may be a biopolymer such as silk and may be modified using organic compounds such as tyrosines to provide a molecular-level interface between the provided bulk biopolymer of the biopolymer optical device and a substrate or other conducting layer via a tyrosine-enzyme polymerization. The enzymatically polymerizing may include catalyzing the organic compound with peroxidase enzyme reactions. The result is a carbon-carbon conjugated backbone that provides polymeric “wires” for use in polymer and biopolymer optical devices. An all organic biopolymer electroactive material is thereby provided that provides optical functions and features.
摘要翻译： 制造生物聚合物光学器件的方法包括提供聚合物，提供基底，将聚合物浇注到基底上，以及将有机化合物酶促聚合以在所提供的聚合物和基底之间产生导电聚合物。 聚合物可以是诸如丝的生物聚合物，并且可以使用有机化合物如酪氨酸进行改性，以通过酪氨酸 - 酶聚合提供生物聚合物光学器件的所提供的本体生物聚合物与底物或其它导电层之间的分子水平界面。 酶促聚合可包括用过氧化物酶反应催化有机化合物。 结果是碳 - 碳共轭骨架提供用于聚合物和生物聚合物光学器件的聚合物“丝线”。 由此提供了提供光学功能和特征的全部有机生物聚合物电活性材料。
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.023 秒)