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    Expandable ablation burr
    2.
    发明授权
    Expandable ablation burr 失效
    可扩展消融毛刺

    公开(公告)号：US07252674B2

    公开(公告)日：2007-08-07

    申请号：US10770336

    申请日：2004-02-02

    申请人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Tom J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

    发明人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Tom J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

    IPC分类号： A61B17/32

    CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

    摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.

    摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。 该系统包括具有设置在近端的磨料的消融毛刺。 当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。

    Expandable ablation burr
    3.
    发明授权
    Expandable ablation burr 失效
    可扩展消融毛刺

    公开(公告)号：US06685718B1

    公开(公告)日：2004-02-03

    申请号：US09629771

    申请日：2000-07-31

    申请人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Thomas J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

    发明人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Thomas J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

    IPC分类号： A61B1732

    CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

    摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.

    摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 当毛刺旋转时，聚合物管通过离心力膨胀。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。 该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。 当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

    Hydrophilic lubricity coating for medical devices comprising an antiblock agent
    5.
    发明授权
    Hydrophilic lubricity coating for medical devices comprising an antiblock agent 有权
    用于包含抗粘连剂的医疗装置的亲水润滑性涂层

    公开(公告)号：US06673053B2

    公开(公告)日：2004-01-06

    申请号：US09307309

    申请日：1999-05-07

    申请人： Lixiao Wang ,  Irina Nazarova

    发明人： Lixiao Wang ,  Irina Nazarova

    IPC分类号： A61M532

    CPC分类号： A61L29/145 ,  A61L29/085 ,  C08L35/00

    摘要： The present invention relates to a medical device for insertion into the body wherein said device has at least one surface which periodically comes into contact with a second surface, the first surface comprising a lubricious hydrophilic coating disposed thereon, said hydrophilic coating further comprising at least one antiblock agent.

    摘要翻译： 本发明涉及一种用于插入身体的医疗装置，其中所述装置具有周期性地与第二表面接触的至少一个表面，第一表面包括设置在其上的润滑亲水涂层，所述亲水涂层还包括至少一个 防粘剂。

    Hydrophilic coating that reduces particle development on ester-linked poly(ester-block-amide)
    10.
    发明授权
    Hydrophilic coating that reduces particle development on ester-linked poly(ester-block-amide) 有权
    亲水性涂料，可降低酯基聚（酯 - 嵌段 - 酰胺）上的颗粒发育

    公开(公告)号：US08617586B2

    公开(公告)日：2013-12-31

    申请号：US12704390

    申请日：2010-02-11

    申请人： Irina Nazarova ,  Jeffrey S. Lindquist ,  Daniel J. Horn

    发明人： Irina Nazarova ,  Jeffrey S. Lindquist ,  Daniel J. Horn

    IPC分类号： A61M25/10

    CPC分类号： A61L29/085 ,  A61L29/14 ,  A61L29/145 ,  Y10T428/265 ,  Y10T428/31786

    摘要： Articles such as catheters or balloons that have an ester-linked poly(ester-block-amide) substrate have a lubricious hydrogel coating which suppresses particle development under accelerated aging conditions. A polymerizable coating composition is applied to the substrate without application of an intervening primer layer and cured. The coating composition comprises an uncrosslinked polyvinylpyrrolidone polymer that is free of attached photoinitiator groups and at least one polyfunctional ethylenically unsaturated monomer.

    摘要翻译： 具有酯交联聚（酯 - 嵌段 - 酰胺）基材的导管或气囊的制品具有润滑的水凝胶涂层，其抑制在加速老化条件下的颗粒发育。 将可聚合涂层组合物施加到基材上，而不施加中间底漆层并固化。 涂料组合物包含不含附着的光引发剂基团和至少一种多官能烯属不饱和单体的未交联的聚乙烯吡咯烷酮聚合物。