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    Drug-Coated Medical Devices for Differential Drug Release
    4.
    发明申请
    Drug-Coated Medical Devices for Differential Drug Release 审中-公开
    用于差异药物释放的药物涂层医疗器械

    公开(公告)号：US20090198321A1

    公开(公告)日：2009-08-06

    申请号：US12363011

    申请日：2009-01-30

    申请人： Derek Sutermeister ,  Benjamin Arcand ,  Raed Rizq ,  Adam Wentland ,  Jay Rassat

    发明人： Derek Sutermeister ,  Benjamin Arcand ,  Raed Rizq ,  Adam Wentland ,  Jay Rassat

    IPC分类号： A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/61

    摘要： The embodiments described herein relate generally to medical devices that are useful for delivering one or more therapeutic agents to a body tissue of a subject, and methods for making and using such devices. In particular, the embodiments relate to a medical device such as a stent having a sidewall structure comprising a plurality of struts, in which one or more therapeutic agents are released from different surfaces of the struts at different release profiles. More particularly, the embodiments relate to a stent having a sidewall structure comprising a plurality of struts, in which the two side surfaces of each strut are coated with a coating composition that is different from the coating composition used to coat the outer surface and/or inner surface of the strut.

    摘要翻译： 本文所述的实施方案一般涉及可用于将一种或多种治疗剂递送至受试者的身体组织的医疗装置，以及用于制造和使用这些装置的方法。 具体地，实施例涉及医疗装置，例如具有侧壁结构的支架，其包括多个支柱，其中一个或多个治疗剂在不同释放曲线下从支柱的不同表面释放。 更具体地，实施例涉及一种具有侧壁结构的支架，该侧壁结构包括多个支柱，其中每个支柱的两个侧表面涂覆有与用于涂覆外表面的涂料组合物不同的涂料组合物和/或 支柱的内表面。

    Medical devices having adherent polymeric layers with depth-dependent properties
    6.
    发明授权
    Medical devices having adherent polymeric layers with depth-dependent properties 有权
    具有与深度相关性质的贴壁聚合物层的医疗装置

    公开(公告)号：US07919137B2

    公开(公告)日：2011-04-05

    申请号：US11983952

    申请日：2007-11-13

    申请人： Derek Sutermeister ,  Jay Rassat ,  James Anderson

    发明人： Derek Sutermeister ,  Jay Rassat ,  James Anderson

    IPC分类号： A61L33/00 ,  C08J7/18

    CPC分类号： A61L31/10 ,  A61L31/14 ,  Y10T428/31678

    摘要： According to one aspect of the invention, a method of forming a medical device is provided, which includes: (a) contacting a substrate with a solution that contains (i) one or more types of polymers, (ii) a solvent that contains one or more types of solvent species, and (iii) one or more optional agents, for example, one or more therapeutic agents, among others; and (b) removing the solvent from the solution, thereby forming a polymeric layer on the substrate. The composition of the solution is changed over the course of forming the polymeric layer. In another aspect of the invention, a medical device is provided, which includes a substrate and a polymeric layer over the substrate. The polymeric layer contains a copolymer that contains differing first and second monomers. The lower surface of the polymeric layer contacting the substrate has a surface concentration of the first monomer relative to the second monomer that is higher than that of the upper surface of the polymeric layer opposite the substrate.

    摘要翻译： 根据本发明的一个方面，提供了一种形成医疗装置的方法，其包括：（a）使基底与含有（i）一种或多种聚合物的溶液接触，（ii）含有一种 或更多类型的溶剂物质，和（iii）一种或多种任选的试剂，例如一种或多种治疗剂等; 和（b）从溶液中除去溶剂，由此在基材上形成聚合物层。 在形成聚合物层的过程中改变溶液的组成。 在本发明的另一方面，提供了一种医疗装置，其包括衬底和在衬底上的聚合物层。 聚合物层含有含有不同的第一和第二单体的共聚物。 与基材接触的聚合物层的下表面具有相对于第二单体的第一单体的表面浓度高于与基材相对的聚合物层的上表面的表面浓度。