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    NOVEL GAMMA-SECRETASE INHIBITOR
    4.
    发明申请
    NOVEL GAMMA-SECRETASE INHIBITOR 失效
    新型GAMMA-SECRETASE抑制剂

    公开(公告)号：US20110071224A1

    公开(公告)日：2011-03-24

    申请号：US12672326

    申请日：2008-07-01

    申请人： Atsuhiro Abe ,  Hideaki Shimizu ,  Seigo Sawada ,  Hiroshi Kodaira

    发明人： Atsuhiro Abe ,  Hideaki Shimizu ,  Seigo Sawada ,  Hiroshi Kodaira

    IPC分类号： A61K31/198 ,  C07C229/28 ,  A61P25/28

    CPC分类号： C07K5/0207 ,  A61K38/00

    摘要： It is intended to provide a novel compound that has an excellent γ-secretase inhibitory effect and specifically inhibits Aβ production.The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; R2 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; R3 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; R4 represents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol “*” represents a chiral center.

    摘要翻译： 本发明提供具有优异的γ-分泌酶抑制效果并特异性抑制A＆bgr的新型化合物。 生产。 本发明提供下式（1）的化合物或其药学上可接受的盐：其中R1表示具有1-4个碳原子的直链或支链烷基或苯基; R2表示可被一个或多个苯基或卤代苯基取代的具有1至4个碳原子的直链或支链烷基; R3表示可以被一个或多个羟基取代的具有1至4个碳原子的直链或支链烷基; R4代表具有1-4个碳原子的直链或支链烷基; 符号“*”表示手性中心。

    Method for preparing polymorphism of irinotecan hydrochloride
    6.
    发明授权
    Method for preparing polymorphism of irinotecan hydrochloride 失效
    盐酸伊立替康多态性的制备方法

    公开(公告)号：US07488825B2

    公开(公告)日：2009-02-10

    申请号：US10546687

    申请日：2004-02-24

    申请人： Hideaki Shimizu ,  Atsuhiro Abe ,  Takashi Yaegashi ,  Seigo Sawada

    发明人： Hideaki Shimizu ,  Atsuhiro Abe ,  Takashi Yaegashi ,  Seigo Sawada

    IPC分类号： C07D491/22

    CPC分类号： C07D491/22

    摘要： A method for preparing a novel crystalline polymorphic irinotecan hydrochloride which is excellent in the solubility in water and reduced in the content of impurities is provided. A method for preparing c-type crystals of irinotecan hydrochloride having diffraction peaks (2θ) at 9.15°, 10.00°, 11.80°, 12.20°, 13.00° and 13.40° in the powder X-ray diffractometry characterized by mixing irinotecan with one or more solvents selected from the group consisting of acetone, acetonitrile and tetrahydrofuran, adding hydrochloric acid, and collecting the formed crystals.

    摘要翻译： 提供了一种制备在水中的溶解性优异且杂质含量降低的新型结晶多晶异氟酸盐酸伊立替康的方法。 在粉末X射线衍射法中，制备在9.15°，10.00°，11.80°，12.20°，13.00°和13.40°具有衍射峰（2θ）的伊立替康盐酸盐的c型晶体的方法，其特征在于将伊立替康与一种或多种 选自丙酮，乙腈和四氢呋喃的溶剂，加入盐酸，收集形成的晶体。

    Taxane derivatives
    7.
    发明授权
    Taxane derivatives 失效
    紫杉烷衍生物

    公开(公告)号：US06268381B1

    公开(公告)日：2001-07-31

    申请号：US09581908

    申请日：2000-06-19

    申请人： Hideaki Shimizu ,  Atsuhiro Abe ,  Takanori Ogawa ,  Hiroshi Nagata ,  Seigo Sawada

    发明人： Hideaki Shimizu ,  Atsuhiro Abe ,  Takanori Ogawa ,  Hiroshi Nagata ,  Seigo Sawada

    IPC分类号： A61K31445

    CPC分类号： C07D405/12 ,  C07D305/14 ,  C07D405/14 ,  C07D407/12

    摘要： The present invention relates to taxane derivatives each represented by the following formula (1): [wherein, A1 represents a group (in which R1 represents H or a (substituted) alkyl group) or a group (in which R2 represents an amino group, a mono- or di-alkylamino group, a piperidino group, a pyrrolidino group or a morpholino group), X represents H, an alkoxycarbonyl group or a benzoyl group, Y represents H or a trialkylsilyl group, A2 represents a furyl group, an alkylfuryl group, an alkyl group or a fluorophenyl group, Ac represents an acetyl group, and Bz represents a benzoyl group] or salts thereof; and drugs containing the same as an active ingredient. These compounds have excellent water solubility and antitumor activity.

    摘要翻译： 本发明涉及各种由下式（1）表示的紫杉烷衍生物：[其中，A1表示基团（其中R1表示H或（取代的（alkyl））烷基）或基团（其中R2表示氨基， 一或二烷基氨基，哌啶子基，吡咯烷子基或吗啉代基），X表示H，烷氧基羰基或苯甲酰基，Y表示H或三烷基甲硅烷基，A2表示呋喃基，烷基 基团，烷基或氟苯基，Ac表示乙酰基，Bz表示苯甲酰基]或其盐; 和含有相同活性成分的药物。这些化合物具有优异的水溶性和抗肿瘤活性。

    γ-secretase inhibitor
    8.
    发明授权
    γ-secretase inhibitor 失效
    γ-分泌酶抑制剂

    公开(公告)号：US08501813B2

    公开(公告)日：2013-08-06

    申请号：US12672326

    申请日：2008-07-01

    申请人： Atsuhiro Abe ,  Hideaki Shimizu ,  Seigo Sawada ,  Hiroshi Kodaira

    发明人： Atsuhiro Abe ,  Hideaki Shimizu ,  Seigo Sawada ,  Hiroshi Kodaira

    IPC分类号： A01N37/18 ,  A61K31/16 ,  C07C233/00 ,  C07C235/00 ,  C07C237/00 ,  C07C239/00

    CPC分类号： C07K5/0207 ,  A61K38/00

    摘要： It is intended to provide a novel compound that has an excellent γ-secretase inhibitory effect and specifically inhibits Aβ production.The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; R2 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; R3 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; R4 represents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol “*” represents a chiral center.

    摘要翻译： 旨在提供具有优异的γ-分泌酶抑制作用并特异性抑制Abeta产生的新型化合物。 本发明提供下式（1）的化合物或其药学上可接受的盐：其中R1表示具有1-4个碳原子的直链或支链烷基或苯基; R2表示可被一个或多个苯基或卤代苯基取代的具有1至4个碳原子的直链或支链烷基; R3表示可以被一个或多个羟基取代的具有1至4个碳原子的直链或支链烷基; R4代表具有1-4个碳原子的直链或支链烷基; 符号“*”表示手性中心。

    VAPOR DEPOSITION APPARATUS AND VAPOR DEPOSITION METHOD
    9.
    发明申请
    VAPOR DEPOSITION APPARATUS AND VAPOR DEPOSITION METHOD 审中-公开
    蒸气沉积装置和蒸气沉积方法

    公开(公告)号：US20100310767A1

    公开(公告)日：2010-12-09

    申请号：US12781064

    申请日：2010-05-17

    申请人： Atsuhiro Abe

    发明人： Atsuhiro Abe

    IPC分类号： C23C16/458 ,  C23C16/00

    CPC分类号： C23C14/24 ,  C23C14/50 ,  C23C14/562

    摘要： A vapor deposition apparatus includes: a vacuum tank; an exhaust section that performs vacuum exhaust in the vacuum tank; a vapor deposition source disposed in the vacuum tank to vaporize a deposition material; and a traveling path for allowing an elongated substrate on which the deposition material is deposited to travel along a concave path with respect to the vapor deposition source at least in a region opposing the vapor deposition source.

    摘要翻译： 蒸镀装置包括：真空槽; 排气部，其在真空槽内进行真空排气; 设置在所述真空容器中以蒸发沉积材料的气相沉积源; 并且至少在与气相沉积源相对的区域中，允许沉积沉积材料的细长基板沿相对于气相沉积源的凹形路径行进的行进路径。

    Apparatus for producing thin film, process for producing thin film and guide roller
    10.
    发明授权
    Apparatus for producing thin film, process for producing thin film and guide roller 失效
    薄膜制造装置，薄膜​​和导辊的制造方法

    公开(公告)号：US06319325B1

    公开(公告)日：2001-11-20

    申请号：US09505185

    申请日：2000-02-16

    申请人： Ryoichi Hiratsuka ,  Kikuji Kawakami ,  Yoshihito Ebine ,  Atsuhiro Abe ,  Yukihiro Koshika

    发明人： Ryoichi Hiratsuka ,  Kikuji Kawakami ,  Yoshihito Ebine ,  Atsuhiro Abe ,  Yukihiro Koshika

    IPC分类号： C23C1600

    CPC分类号： C23C16/545 ,  G11B5/85

    摘要： It is to provide an apparatus for producing a thin film, a process for producing a thin film and a guide roller, in which an arc resistant property is provided, and the film formation can be stably conducted with preventing damage of the thin film thus formed. In an apparatus for producing a thin film, such as a plasma CVD apparatus, comprising a vacuum chamber, means for generating a plasma in the vacuum chamber, means for introducing a gas to the vacuum chamber, and a guide roller for running a material to be treated by winding and supporting in the vacuum chamber, an outer peripheral surface of the guide roller in contact and sliding with the material to be treated comprises an electric conductor on both end parts in a width direction of the guide roller, and an electric insulator on a central part thereof.

    摘要翻译： 本发明提供一种薄膜制造装置，制造耐电弧性能的薄膜和导向辊的制造方法，能够稳定地进行成膜，同时防止由此形成的薄膜的损伤 。 在用于制造薄膜的设备中，诸如等离子体CVD装置，包括真空室，用于在真空室中产生等离子体的装置，用于将气体引入真空室的装置，以及用于将材料运送到 通过在真空室中卷绕和支撑来处理，导辊的外周表面与待处理的材料接触并滑动，包括在引导辊的宽度方向上的两个端部上的电导体和电绝缘体 在其中央部分。