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公开(公告)号：US20100315588A1
公开(公告)日：2010-12-16
申请号：US12456422
申请日：2009-06-16
申请人： Ivan M. Nunez , Jeffrey G. Linhardt , Joseph A. McGee , Jennifer Hunt , Michele Alton , Devon A. Shipp , Jay F. Kunzler , Daniel M. Ammon, JR.
发明人： Ivan M. Nunez , Jeffrey G. Linhardt , Joseph A. McGee , Jennifer Hunt , Michele Alton , Devon A. Shipp , Jay F. Kunzler , Daniel M. Ammon, JR.
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a hydrophilic polymer comprising one or more hydrophilic units and one or more thio carbonyl thio fragments of a reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.
摘要翻译： 生物医学装置，例如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）包含一个或多个亲水单元的亲水性聚合物和一个或多个可逆加成断裂链转移（“RAFT”）试剂的一个或多个硫羰基硫代片段; 和（b）公开了一种或多种生物医学装置形成单体。
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公开(公告)号：US09285508B2
公开(公告)日：2016-03-15
申请号：US12456423
申请日：2009-06-16
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a multi-armed macromonomer comprising multiple side chains attached to a nucleus, wherein each side chain comprises a thio carbonyl thio fragment of the same or different reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.
摘要翻译： 生物医学装置，例如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）包含连接到核的多个侧链的多臂大分子单体，其中每个侧链包含相同或不同的可逆加成断裂的硫代羰基硫代片段 链转移（“RAFT”）代理; 和（b）公开了一种或多种生物医学装置形成单体。
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公开(公告)号：US20100318185A1
公开(公告)日：2010-12-16
申请号：US12456423
申请日：2009-06-16
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising (a) a multi-armed macromonomer comprising multiple side chains attached to a nucleus, wherein each side chain comprises a thio carbonyl thio fragment of the same or different reversible addition fragmentation chain transfer (“RAFT”) agent; and (b) one or more biomedical device-forming monomers are disclosed.
摘要翻译： 生物医学装置，例如由混合物的聚合产物形成的隐形眼镜，所述混合物包含（a）包含连接到核的多个侧链的多臂大分子单体，其中每个侧链包含相同或不同的可逆加成断裂的硫代羰基硫代片段 链转移（“RAFT”）代理; 和（b）公开了一种或多种生物医学装置形成单体。
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公开(公告)号：US20120329905A1
公开(公告)日：2012-12-27
申请号：US13483397
申请日：2012-05-30
申请人： Ivan M. Nunez , Jay F. Kunzler , Jennifer Hunt , Joseph A. McGee
发明人： Ivan M. Nunez , Jay F. Kunzler , Jennifer Hunt , Joseph A. McGee
IPC分类号： C08G63/688 , C07C333/20 , C07C333/04 , C08L81/00
CPC分类号： C07C333/04
摘要： An optical copolymer comprising: a constituent derived from a sulfated lens monomer of general formula I [PG-R1—NHC(Y)S—R2]n—R3 I PG is a polymerizable group selected from the group consisting of vinyl, acryloyl, acryoyloxy, methacryoyl and methacryoyloxy; acrylamido and methacrylamido; Y is oxygen or sulfur; and n is 2, 3 or 4. Also, R1 is an organic group of one to eight carbon atoms and optionally with one or more oxygen atoms or an aromatic ring. R2 is a bond or an organic group of one to six carbon atoms. R3 is a bond, an organic group of one to ten carbons atoms, carbon, oxygen, sulfur or a disulfide; and a lens monomer. The sulfated lens monomer is derived from a first component of formula, PG-R1—NC(Y), and a polythiol of formula, R3—[R2—SH]n.
摘要翻译： 一种光学共聚物，其包含：衍生自通式I的硫酸化透镜单体的组分[PG-R 1 -NHC（Y）S-R 2] n -R 3 I PG是选自乙烯基，丙烯酰基，丙烯酰氧基 ，甲基丙烯酰基和甲基丙烯酰氧基; 丙烯酰胺和甲基丙烯酰胺; Y是氧或硫; n为2,3或4.另外，R 1为碳原子数为1〜8的有机基团，且可以具有一个以上的氧原子或芳香环。 R2是1-6个碳原子的键或有机基团。 R3是一个键，一至十个碳原子的有机基团，碳，氧，硫或二硫键; 和透镜单体。 硫酸化透镜单体衍生自式的第一组分PG-R1-NC（Y）和式R3- [R2-SH] n的多硫醇。
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公开(公告)号：US08083348B2
公开(公告)日：2011-12-27
申请号：US12456420
申请日：2009-06-16
CPC分类号： G02B1/043 , C08F20/56 , C08F26/08 , C08F118/02 , C08F226/02 , C08L81/00 , C08L83/10
摘要： Biomedical devices such as contact lenses formed from a polymerization product of a mixture comprising an ethylenically unsaturated-containing non-amphiphilic macromonomer comprising hydrophilic units or hydrophobic units derived from a living radical polymerization of one or more ethylenically unsaturated hydrophilic monomers or one or more ethylenically unsaturated hydrophobic monomers are disclosed.
摘要翻译： 生物医学装置，例如由含有烯键式不饱和的非两亲性大分子单体的混合物的聚合产物形成的隐形眼镜，其包含亲水单元或衍生自一种或多种烯属不饱和亲水单体的活性自由基聚合的疏水单元或一种或多种烯属不饱和单体 公开疏水单体。
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公开(公告)号：US08100528B2
公开(公告)日：2012-01-24
申请号：US12334619
申请日：2008-12-15
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译： 本发明涉及一种装置的表面处理。 表面处理包括通过与沿着聚合物基底的单体单元的互补表面官能团反应的分段嵌段共聚物的相互作用官能团将相互作用的嵌段共聚物连接到基材的表面。 本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，其包括由 这样一种方法。
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公开(公告)号：US20090171027A1
公开(公告)日：2009-07-02
申请号：US12334615
申请日：2008-12-15
IPC分类号： C08F299/00
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward interactive segmented block copolymers useful to treat the surface of a substrate by means of interactive functionalities of the interactive segmented block copolymer material binding with complementary surface functionalities of the polymer substrate.
摘要翻译： 本发明涉及用于通过与聚合物基质的互补表面官能团结合的相互作用的分段嵌段共聚物材料的相互作用功能来处理基材表面的相互作用的嵌段共聚物。
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公开(公告)号：US07942929B2
公开(公告)日：2011-05-17
申请号：US12334618
申请日：2008-12-15
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译： 本发明涉及一种装置的表面处理。 表面处理包括通过末端官能化表面活性剂材料与沿聚合物基质的单体单元的互补表面反应性官能团反应的反应性官能团将反应性嵌段共聚物附着到基材表面。 本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，包括由 这样一种方法。
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9.发明申请公开(公告)号：US20090171459A1
公开(公告)日：2009-07-02
申请号：US12334618
申请日：2008-12-15
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of reactive segmented block copolymers to the surface of the substrate by means of reactive functionalities of the terminal functionalized surfactant material reacting with complementary surface reactive functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译： 本发明涉及一种装置的表面处理。 表面处理包括通过末端官能化表面活性剂材料与沿聚合物基质的单体单元的互补表面反应性官能团反应的反应性官能团将反应性嵌段共聚物附着到基材表面。 本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，包括由 这样一种方法。
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公开(公告)号：US20090171049A1
公开(公告)日：2009-07-02
申请号：US12333345
申请日：2008-12-12
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward reactive segmented block copolymers useful to treat the surface of a substrate by means of reactive functionalities of the reactive segmented block copolymer material reacting with complementary surface reactive functionalities of the polymer substrate.
摘要翻译： 本发明涉及用于通过与聚合物基质的互补表面反应性官能团反应的反应性嵌段共聚物材料的反应性官能团来处理基材表面的反应性分段嵌段共聚物。
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