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18 条记录 (耗时 0.022 秒)

    Catalytic synthesis of N-alkylated anilines from olefins and anilines
    1.
    发明授权
    Catalytic synthesis of N-alkylated anilines from olefins and anilines 失效
    从烯烃和苯胺催化合成N-烷基化苯胺

    公开(公告)号：US06222073B1

    公开(公告)日：2001-04-24

    申请号：US09600267

    申请日：2000-07-03

    申请人： Jürgen Herwig ,  Matthias Beller ,  Claudia Breindl ,  Harald Trauthwein ,  Elisabeth Eichberger ,  Anton Eichberger

    发明人： Jürgen Herwig ,  Matthias Beller ,  Claudia Breindl ,  Harald Trauthwein ,  Elisabeth Eichberger ,  Anton Eichberger

    IPC分类号： C07C20900

    CPC分类号： C07C213/00 ,  C07C209/60 ,  C07C211/48 ,  C07C217/84

    摘要： Process for the preparation of an N-arylethylaniline of the formula (I) Ar—N(R1)2-n(CHR2CHR3Ar′)n  (I) by reacting an aromatic olefin of the formula (II) Ar′CR3=CHR2  (II) with an aniline of the formula (III) Ar—N(R1)2-n(H)n  (III) in an inert solvent in the presence of at least one basic catalyst selected from the group consisting of alkali metal alcoholates and alkaline earth metal alcoholates or alkali metal amides and alkaline earth metal amides, where, in the formulae (I) to (III), Ar and Ar′, independently of one another, are an aryl radical selected from the group consisting of the fused and nonfused C6-C22-aromatics and of the fused or nonfused C5-C22heteroaromatics which have at least one nitrogen, oxygen or sulfur atom in the ring; R1, R2 and R3, independently of one another, are a hydrogen atom, a C1-C8-alkyl radical or an aryl radical Ar; and n is the number 1 or 2.

    摘要翻译： 通过使式（II）的芳族烯烃与式（III）的苯胺在惰性溶剂中在至少一种选自以下的碱式催化剂的存在下反应制备式（I）的N-芳基乙基苯胺的方法： 由碱金属醇化物和碱土金属醇化物或碱金属氨化物和碱土金属酰胺组成的组中，其中在式（I）至（III）中，Ar和Ar'彼此独立地为选自 由稠合和未填充的C 6 -C 22芳族化合物和在环中具有至少一个氮，氧或硫原子的稠合或未稠合的C 5 -C 22杂原子取代基组成的组; R 1，R 2和R 3彼此独立地是 氢原子，C1-C8-烷基或芳基Ar; andn是数字1或2。

    Method for producing (meth)acrylates
    6.
    发明授权
    Method for producing (meth)acrylates 失效
    （甲基）丙烯酸酯的制造方法

    公开(公告)号：US08049030B2

    公开(公告)日：2011-11-01

    申请号：US12667599

    申请日：2008-05-08

    申请人： Guido Protzmann ,  Harald Trauthwein ,  Joachim Knebel ,  Thorben Schuetz ,  Gerhard Koelbl ,  Thomas Kehr ,  Guenther Lauster

    发明人： Guido Protzmann ,  Harald Trauthwein ,  Joachim Knebel ,  Thorben Schuetz ,  Gerhard Koelbl ,  Thomas Kehr ,  Guenther Lauster

    IPC分类号： C07C67/02

    CPC分类号： C07C67/03 ,  C07C67/54 ,  C07C69/54

    摘要： The present invention relates to a process for preparing (meth)acrylates, which comprises the transesterification of an alcohol with a low-boiling ester of (meth)acrylic acid in the presence of catalysts, with the alcohol liberated from the low-boiling ester of (meth)acrylic acid being separated off by distillation, characterized in that the molar ratio of low-boiling ester of (meth)acrylic acid to starting alcohol present in the reaction mixture is increased during the reaction by addition of low-boiling ester of (meth)acrylic acid. The process of the invention makes a particularly inexpensive preparation of (meth)acrylates having a very high purity possible.

    摘要翻译： 本发明涉及一种制备（甲基）丙烯酸酯的方法，其包括在催化剂存在下醇与低沸点酯（（甲基）丙烯酸）的酯交换反应，从低沸点酯 （甲基）丙烯酸通过蒸馏分离，其特征在于反应中存在的（甲基）丙烯酸的低沸点酯与起始醇的摩尔比在反应期间通过加入低沸点酯（ 甲基）丙烯酸。 本发明的方法使得可以特别廉价地制备具有非常高纯度的（甲基）丙烯酸酯。

    METHOD FOR PRODUCING (METH)ACRYLATES
    7.
    发明申请
    METHOD FOR PRODUCING (METH)ACRYLATES 失效
    生产（甲基）丙烯酸酯的方法

    公开(公告)号：US20100204509A1

    公开(公告)日：2010-08-12

    申请号：US12667599

    申请日：2008-05-08

    申请人： Guido Protzmann ,  Harald Trauthwein ,  Joachim Knebel ,  Thorben Schuetz ,  Gerhard Koelbl ,  Thomas Kehr ,  Guenther Lauster

    发明人： Guido Protzmann ,  Harald Trauthwein ,  Joachim Knebel ,  Thorben Schuetz ,  Gerhard Koelbl ,  Thomas Kehr ,  Guenther Lauster

    IPC分类号： C07C67/03

    CPC分类号： C07C67/03 ,  C07C67/54 ,  C07C69/54

    摘要： The present invention relates to a process for preparing (meth)acrylates, which comprises the transesterification of an alcohol with a low-boiling ester of (meth)acrylic acid in the presence of catalysts, with the alcohol liberated from the low-boiling ester of (meth)acrylic acid being separated off by distillation, characterized in that the molar ratio of low-boiling ester of (meth)acrylic acid to starting alcohol present in the reaction mixture is increased during the reaction by addition of low-boiling ester of (meth)acrylic acid. The process of the invention makes a particularly inexpensive preparation of (meth)acrylates having a very high purity possible.

    摘要翻译： 本发明涉及一种制备（甲基）丙烯酸酯的方法，其包括在催化剂存在下醇与低沸点酯（（甲基）丙烯酸）的酯交换反应，从低沸点酯 （甲基）丙烯酸通过蒸馏分离，其特征在于反应中存在的（甲基）丙烯酸的低沸点酯与起始醇的摩尔比在反应期间通过加入低沸点酯（ 甲基）丙烯酸。 本发明的方法使得可以特别廉价地制备具有非常高纯度的（甲基）丙烯酸酯。

    Novel Alcohol Dehydrogenases
    9.
    发明申请
    Novel Alcohol Dehydrogenases 有权
    新型酒精脱氢酶

    公开(公告)号：US20080216181A1

    公开(公告)日：2008-09-04

    申请号：US10593119

    申请日：2005-03-10

    申请人： Renate Schulze ,  Patrick Lorenz ,  Jurgen Eck ,  Oliver May ,  Harald Groger ,  Harald Trauthwein

    发明人： Renate Schulze ,  Patrick Lorenz ,  Jurgen Eck ,  Oliver May ,  Harald Groger ,  Harald Trauthwein

    IPC分类号： A01K67/027 ,  C12N9/02 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06

    CPC分类号： C12P7/02 ,  C12N9/0006 ,  C12Y101/01002

    摘要： The invention relates to novel polypeptides which have the biological activity of an NAD- or NADP-dependent alcohol dehydrogenase. The invention furthermore relates to nucleic acids encoding said polypeptides, to non-human hosts or host cells and to reaction systems which may be used for preparing desired products. The polypeptides of the invention are preferably used in the preparation, starting from aldehydes or ketones, of primary and enantiomerically pure secondary alcohol's which may serve as intermediates for medicaments. Alternatively, the polypeptides of the invention may also be employed in the reverse reaction, i.e. the oxidation of alcohol's with the formation of aldehydes or ketones.

    摘要翻译： 本发明涉及具有NAD-或NADP依赖性醇脱氢酶的生物活性的新型多肽。 本发明还涉及编码所述多肽，非人宿主或宿主细胞的核酸以及可用于制备所需产物的反应体系。 本发明的多肽优选用于从醛或酮开始制备可以作为药物中间体的初级和对映体纯的仲醇。 或者，也可以将本发明的多肽用于反向反应，即醇与醛或酮的形成的氧化。