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    DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF
    1.
    发明申请
    DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF 有权
    二烷基（2-烷氧基-6-氨基苯基）膦，其制备方法及其用途

    公开(公告)号：US20140309422A1

    公开(公告)日：2014-10-16

    申请号：US14114704

    申请日：2012-07-03

    Applicant: Shengming Ma ,  Bo Lv ,  Chunling Fu

    Inventor： Shengming Ma ,  Bo Lv ,  Chunling Fu

    IPC: C07F9/59 ,  C07F9/50

    CPC classification number: C07F9/59 ,  B01J31/189 ,  B01J2231/42 ,  B01J2531/824 ,  C07F9/5022

    Abstract: The present invention relates to the compound of dialkyl(2-alkoxy-6-aminophenyl)phosphine and the preparation method thereof and the application in the palladium catalyzed coupling reactions of aryl chloride and ketone. The dialkyl(2-alkoxy-6-aminophenyl)phosphine of the present invention could coordinate with the palladium catalyst to highly selectively activate the inert carbon-chlorine bond, and to catalyze direct arylation reaction in the α-position of ketones to produce corresponding coupling compounds. The preparation method of the present invention is a simple one-step method which produces the air-stable dialkyl(2-alkoxy-6-aminophenyl)phosphine. Compared with the synthetic routes of ligands to be used in the activation of carbon-chlorine bonds in the prior arts, the preparation method of the present invention has the advantages of short route and easy operation.

    Abstract translation: 本发明涉及二烷基（2-烷氧基-6-氨基苯基）膦的化合物及其制备方法以及在芳基氯和酮的钯催化偶联反应中的应用。 本发明的二烷基（2-烷氧基-6-氨基苯基）膦可以与钯催化剂配位，以高度选择性地活化惰性碳 - 氯键，并催化酮的α-位上的直接芳基化反应产生相应的偶联 化合物。 本发明的制备方法是产生空气稳定的二烷基（2-烷氧基-6-氨基苯基）膦的简单的一步法。 与现有技术中用于活化碳 - 氯键的配体的合成路线相比，本发明的制备方法具有路线短，操作方便的优点。

    WATER-STABLE COMPOUNDS, CATALYSTS AND CATALYSED REACTIONS
    2.
    发明申请
    WATER-STABLE COMPOUNDS, CATALYSTS AND CATALYSED REACTIONS 审中-公开
    水稳定化合物，催化剂和催化反应

    公开(公告)号：US20100292449A1

    公开(公告)日：2010-11-18

    申请号：US12665387

    申请日：2008-06-16

    Applicant: Arran Alexander Dickon Tulloch ,  Alan Cooper ,  Robert Hume Duncan

    Inventor： Arran Alexander Dickon Tulloch ,  Alan Cooper ,  Robert Hume Duncan

    IPC: C07C291/08 ,  B01J31/12 ,  C07C69/80

    CPC classification number: B01J31/2243 ,  B01J31/2247 ,  B01J2231/342 ,  B01J2231/42 ,  B01J2231/70 ,  B01J2531/31 ,  B01J2531/46 ,  B01J2531/48 ,  B01J2531/842 ,  B01J2531/96

    Abstract: The invention provides a method of carrying out a Lewis-acid catalysed organic reaction in the presence of a Lewis acid catalyst comprising a metal-organic compound having the following formula: M(HO(CR1R2)z)a(O(CR1R2)z)bY—(CR3R4)χ-Y((CR1R2)zO)c((CR1R2)zOH)d.nR5OH (Formula I) in which: M is a metal atom, preferably titanium, zirconium, hafnium or iron (III) Y is selected from P and N, but Ss very preferably N; each R1, R2, R3 and R4 is independently selected from H, alkyl, aryl, substituted alkyl or substituted aryl, R5 is hydrogen, an alkyl group, a hydroxy-functionalised alkyl group, a polyoxyalkylmoiety, R6O or R7COO where R6 and R7 may each represent H, alkyl, aryl or alkyl-aryl; d and a are each O or 1, b and c are each 1 or 2, b+c=the valency of M, a+b+c+d=4, each z is independently 1, 2, 3 or 4; x represents the least number of C atoms between the Y atoms and is 2 or 3 and n is a number in the range from 0 to 4. The metal-organic compound forms a stable hydrate in water which retains Lewis-acid catalytic properties.

    Abstract translation: 本发明提供一种在路易斯酸催化剂存在下进行路易斯酸催化的有机反应的方法，该路易斯酸催化剂包含具有下式的金属有机化合物：M（HO（CR 1 R 2）z）a（O（CR 1 R 2）z） bY-（CR3R4）χ-Y（（CR1R2）zO）c（（CR1R2）zOH）d.nR5OH（式I）其中：M是金属原子，优选钛，锆，铪或铁（III）Y是 选自P和N，但S优选为N; 每个R 1，R 2，R 3和R 4独立地选自H，烷基，芳基，取代的烷基或取代的芳基，R 5是氢，烷基，羟基官能化的烷基，聚氧烷基摩尔，R6O或R7COO，其中R6和R7可以 各自表示H，烷基，芳基或烷基 - 芳基; d和a各自为O或1，b和c各自为1或2，b + c = M的化合价，a + b + c + d = 4，每个z独立地为1,2,3或4; x表示Y原子之间的C原子数最少，为2或3，n为0至4的数。该金属有机化合物在水中形成稳定的水合物，保留路易斯酸催化性能。

    Catalyst comprising N-substituted cyclic imide compound and process for producing organic compounds using the catalyst
    3.
    发明授权
    Catalyst comprising N-substituted cyclic imide compound and process for producing organic compounds using the catalyst 有权
    包含N-取代的环状酰亚胺化合物的催化剂和使用该催化剂制备有机化合物的方法

    公开(公告)号：US07759515B2

    公开(公告)日：2010-07-20

    申请号：US11434243

    申请日：2006-05-16

    Applicant: Yasutaka Ishii ,  Naruhisa Hirai ,  Masahiko Terada

    Inventor： Yasutaka Ishii ,  Naruhisa Hirai ,  Masahiko Terada

    IPC: C07C63/00

    CPC classification number: C07C45/36 ,  B01J31/0247 ,  B01J31/2243 ,  B01J2231/42 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/72 ,  B01J2531/845 ,  Y02P20/55

    Abstract: A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

    Abstract translation: 本发明的催化剂包括具有由下式（I）表示的N-取代的环状酰亚胺骨架的酰亚胺化合物：其中R是羟基保护基。 优选的R是可水解的保护基团。 R可以是从酸中除去OH基团而获得的基团。 这些酸包括例如羧酸，磺酸，碳酸，氨基甲酸，硫酸，硝酸，磷酸和硼酸。 催化剂可以组合包括酰亚胺化合物和金属化合物。 在催化剂存在下，使（A）能够形成自由基的化合物与（B）自由基清除化合物反应，从而得到化合物（A）和化合物（B）的加成或取代反应产物， 或其衍生物。 作为例如在温和条件下的添加或取代反应的结果，该催化剂可以以高产率生产高选择性的有机化合物。

    Catalyst comprising n-substituted cyclic imide compound and process for producing organic compounds using the catalyst
    6.
    发明申请
    Catalyst comprising n-substituted cyclic imide compound and process for producing organic compounds using the catalyst 有权
    包含正取代的环状酰亚胺化合物的催化剂和使用该催化剂制备有机化合物的方法

    公开(公告)号：US20060229196A1

    公开(公告)日：2006-10-12

    申请号：US11434243

    申请日：2006-05-16

    Applicant: Yasutaka Ishii ,  Naruhisa Hirai ,  Masahiko Terada

    Inventor： Yasutaka Ishii ,  Naruhisa Hirai ,  Masahiko Terada

    IPC: C07D471/06 ,  C07D221/04 ,  B01J31/00

    CPC classification number: C07C45/36 ,  B01J31/0247 ,  B01J31/2243 ,  B01J2231/42 ,  B01J2231/70 ,  B01J2231/72 ,  B01J2531/72 ,  B01J2531/845 ,  Y02P20/55

    Abstract: A catalyst of the invention includes an imide compound having a N-substituted cyclic imide skeleton represented by following Formula (I): wherein R is a hydroxyl-protecting group. Preferred R is a hydrolyzable protecting group. R may be a group obtained from an acid by eliminating an OH group therefrom. Such acids include, for example, carboxylic acids, sulfonic acids, carbonic acid, carbamic acid, sulfuric acid, nitric acid, phosphoric acids and boric acids. The catalyst may include the imide compound and a metallic compound in combination. In the presence of the catalyst, (A) a compound capable of forming a radical is allowed to react with (B) a radical scavenging compound and thereby yields an addition or substitution reaction product of the compound (A) and the compound (B) or a derivative thereof. This catalyst can produce an organic compound with a high selectivity in a high yield as a result of, for example, an addition or substitution reaction under mild conditions.

    Abstract translation: 本发明的催化剂包括具有由下式（I）表示的N-取代的环状酰亚胺骨架的酰亚胺化合物：其中R是羟基保护基。 优选的R是可水解的保护基团。 R可以是从酸中除去OH基团而获得的基团。 这些酸包括例如羧酸，磺酸，碳酸，氨基甲酸，硫酸，硝酸，磷酸和硼酸。 催化剂可以组合包括酰亚胺化合物和金属化合物。 在催化剂存在下，使（A）能够形成自由基的化合物与（B）自由基清除化合物反应，从而得到化合物（A）和化合物（B）的加成或取代反应产物， 或其衍生物。 作为例如在温和条件下的添加或取代反应的结果，该催化剂可以以高产率生产高选择性的有机化合物。

    Catalyst composite and methods of making and using
    7.
    发明申请
    Catalyst composite and methods of making and using 审中-公开
    催化剂复合材料及其制造和使用方法

    公开(公告)号：US20060110311A1

    公开(公告)日：2006-05-25

    申请号：US11265032

    申请日：2005-11-02

    Applicant: Felice DiMascio

    Inventor： Felice DiMascio

    IPC: B01J23/40 ,  B01J31/00 ,  C01B11/02

    CPC classification number: C01B11/024 ,  B01J31/08 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/023 ,  B01J37/0009 ,  B01J2231/32 ,  B01J2231/42 ,  B01J2231/52 ,  B01J2231/62 ,  C01B11/00

    Abstract: A catalyst composite includes an agglomerate of a plurality of catalyst composite components and a binder. The catalyst composites may be useful as a catalyst in a variety of chemical processes including hydrogenation, dehydrogenation, hydrogenolysis, oxidation, reduction, alkylation, dealkylation, carbonylation, decarbonylation, coupling, isomerization, amination, deamination, or hydrodehalogenation.

    Abstract translation: 催化剂复合物包括多个催化剂复合组分和粘合剂的附聚物。 催化剂复合物可用作各种化学方法中的催化剂，包括氢化，脱氢，氢解，氧化，还原，烷基化，脱烷基化，羰基化，脱羰基，偶联，异构化，胺化，脱氨基或加氢脱卤。

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