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公开(公告)号：US09005109B2
公开(公告)日：2015-04-14
申请号：US13088133
申请日：2011-04-15
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
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公开(公告)号：US07252632B2
公开(公告)日：2007-08-07
申请号：US10172523
申请日：2002-06-13
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
摘要翻译： 一种心脏约束装置，其包括生物相容性材料夹套和调节构件。 护套适于固定在心脏上，以紧密地符合心脏的外部几何形状，并采取最大调节体积，以限制心脏周围的舒张超过舒张期的最大调节体积，并允许心脏收缩期间不受阻碍的收缩 。 调整机构被配置成在护套被固定到心脏之后改变由夹克限定的内部容积。 本发明还提供了治疗心脏病的方法。
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公开(公告)号：US06908426B2
公开(公告)日：2005-06-21
申请号：US10639875
申请日：2003-08-12
IPC分类号： A61B17/00 , A61F2/00 , A61F2/24 , A61L27/00 , A61L29/00 , A61L31/00 , A61L31/02 , A61L31/04 , A61L31/06 , A61L31/14 , A61F2/04 , A61B19/00
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
摘要翻译： 一种心脏约束装置，其包括生物相容性材料夹套和调节构件。 护套适于固定在心脏上，以紧密地符合心脏的外部几何形状，并采取最大调节体积，以限制心脏周围的舒张超过舒张期的最大调节体积，并允许心脏收缩期间不受阻碍的收缩 。 调整机构被配置成在护套被固定到心脏之后改变由夹克限定的内部容积。 本发明还提供了治疗心脏病的方法。
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公开(公告)号：US07938768B2
公开(公告)日：2011-05-10
申请号：US11668930
申请日：2007-01-30
IPC分类号： A61F2/00
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
摘要翻译： 一种心脏约束装置，其包括生物相容性材料夹套和调节构件。 护套适于固定在心脏上，以紧密地符合心脏的外部几何形状，并采取最大调节体积，以限制心脏周围的舒张超过舒张期的最大调节体积，并允许心脏收缩期间不受阻碍的收缩 。 调整机构被配置成在护套被固定到心脏之后改变由夹克限定的内部容积。 本发明还提供了治疗心脏病的方法。
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公开(公告)号：US06425856B1
公开(公告)日：2002-07-30
申请号：US09567726
申请日：2000-05-10
IPC分类号： A61F1300
CPC分类号： A61L31/148 , A61F2/2481 , A61F2250/0031 , A61L31/005 , A61L31/022 , A61L31/042 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/146 , C08L27/16
摘要： A cardiac constraint device comprising a jacket of biological compatible material and an adjustment member. The jacket is adapted to be secured to the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole. The adjustment mechanism is configured to alter the internal volume defined by the jacket after the jacket is secured to the heart. The invention also provides a method for treating cardiac disease.
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公开(公告)号：US06902522B1
公开(公告)日：2005-06-07
申请号：US09591754
申请日：2000-06-12
CPC分类号： A61F2/2481
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A–V groove, the device including a jacket adapted to be secured to the heart, and a delivery source for the delivery of one or more therapeutic agents to the surface of the heart. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由AV凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套，以及用于将一种或多种治疗剂递送至 心脏的表面。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。
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公开(公告)号：US07326174B2
公开(公告)日：2008-02-05
申请号：US10839724
申请日：2004-05-04
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。
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公开(公告)号：US06730016B1
公开(公告)日：2004-05-04
申请号：US09591875
申请日：2000-06-12
申请人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
发明人： James Cox , Michael J. Girard , Donald F. Palme, II , Donald G. Rohrbaugh , Hani N. Sabbah , J. Edward Shapland, II , Robert G. Walsh
IPC分类号： A61F200
CPC分类号： A61F2/2481 , D04B21/12 , D10B2509/08 , Y10S977/907
摘要： A device for treating cardiac disease of a heart having an upper portion and a lower portion divided by an A-V groove, the device including a jacket adapted to be secured to the heart, and a non-adherent material in association with the jacket. The jacket is fabricated from a flexible material defining a volume between an upper and a lower end, the jacket being adapted to be adjusted on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain expansion of the heart beyond the maximum adjusted volume during diastole and permit substantially unimpeded contraction of the heart during systole. As a result of the flexible material, the jacket allows unimpeded diastolic filling of the heart. Also described is a method for treating cardiac disease including surgically accessing the heart, applying the treatment device of the invention, securing the treatment device to the heart, and surgically closing access to the heart while leaving the treatment device on the heart.
摘要翻译： 一种用于治疗心脏的心脏疾病的装置，其具有由A-V凹槽分隔的上部和下部，所述装置包括适于固定到心脏的护套以及与护套相关联的非粘附材料。 护套由限定上下端之间的体积的柔性材料制成，护套适于在心脏上调节以紧密地符合心脏的外部几何形状，并且假设用于护套约束的最大调节体积 舒张期心脏扩张超出最大调节体积，并允许心脏在收缩期间基本无阻碍地收缩心脏。 作为柔性材料的结果，护套可以无阻碍地舒张心脏填充心脏。 还描述了一种治疗心脏疾病的方法，包括手术进入心脏，施用本发明的治疗装置，将治疗装置固定到心脏，以及在将治疗装置留在心脏上时手术闭合进入心脏。
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9.发明申请DURABLE SMALL GAUGE WIRE ELECTRICAL CONDUCTOR SUITABLE FOR DELIVERY OF HIGH INTENSITY ENERGY PULSES 审中-公开适用于输送高强度能量脉冲的耐用小尺寸电导体公开(公告)号：US20150209576A1
公开(公告)日：2015-07-30
申请号：US14165559
申请日：2014-01-27
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/0563
摘要： Implantable medical devices intended for electrostimulation and sensing devices typically incorporate one or more electrical conductors as leads for electrical stimulation to, or retrieval of localized sensing data from, discrete points in the body, such as the heart. Certain applications require delivery of high intensity electrical pulses, i.e. CRTs, or defibrillators. As described herein a CRT delivers high energy pulses via a durable fine wire lead formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating. A unipolar electrical conductor can have an outer diameter of about 150 microns or even smaller. The buffered fibers support conduction of high intensity electrical pulses as required for internal or external defibrillators, or other biomedical applications, as well as non-medical applications. Defibrillation pulses can be transmitted through less cross-sectional area of metal in the subject fine wire conductor than would be the case with conventional solid core metal wires. Multiple such coated fibers can act as a single conductor. An outer protective sheath of a flexible polymer material can be included.
摘要翻译： 旨在用于电刺激和感测装置的可植入医疗设备通常将一个或多个电导体作为引线用于电刺激或从身体中的离散点（例如心脏）检索局部感测数据。 某些应用需要输送高强度电脉冲，即CRT或除颤器。 如本文所述，CRT通过由具有金属涂层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成的耐用细线引脚提供高能量脉冲。 单极电导体可以具有约150微米或甚至更小的外径。 缓冲的纤维支持内部或外部除颤器或其他生物医学应用以及非医疗应用所需的高强度电脉冲的传导。 除了传统的固体芯金属线材外，除颤脉冲可以通过较小的细线导体中金属的横截面积传递。 多个这样的涂覆纤维可以用作单个导体。 可以包括柔性聚合物材料的外护套。
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10.发明授权Durable fine wire electrical conductor suitable for extreme environment applications 有权耐用的细线电导体适用于极端环境的应用公开(公告)号：US08692117B2
公开(公告)日：2014-04-08
申请号：US12804271
申请日：2010-07-16
申请人： Robert G. Walsh , Jin Shimada , Scott Engle
发明人： Robert G. Walsh , Jin Shimada , Scott Engle
摘要： Durable fine wire electrical conductors are robust, durable, small in profile, and light weight, yet capable of operating under extreme environmental conditions. Formed of a glass, silica, sapphire or crystalline quartz fiber core with a metal coating and one or more polymer layers, a unipolar electrical conductor can have an outer diameter as small as about 300 microns or even smaller. The metal buffer coating may be deposited directly on the glass/silica fiber, or upon an intermediate layer between the glass/silica fiber and metal, consisting of carbon and/or polymer. The resulting metallized glass/silica fibers are extremely durable, can be bent through small radii and will not fatigue even from millions of iterations of flexing. Bipolar electrical conductors can include several insulated metallized glass/silica fibers residing side by side, or can be coaxial with two or more insulated metal conductive paths. An outer protective sheath of a flexible polymer material can be included.
摘要翻译： 耐用的细线电导体坚固耐用，外形小巧，重量轻，但能够在极端环境条件下工作。 由具有金属涂层和一个或多个聚合物层的玻璃，二氧化硅，蓝宝石或结晶石英纤维芯形成，单极电导体可以具有小至约300微米甚至更小的外径。 金属缓冲涂层可以直接沉积在玻璃/二氧化硅纤维上，或者在由碳和/或聚合物组成的玻璃/二氧化硅纤维和金属之间的中间层上。 所得到的金属化玻璃/二氧化硅纤维非常耐用，可以通过小的半径弯曲，并且即使从数百万次的弯曲迭代也不会疲劳。 双极电导体可以包括并排存在的几个绝缘的金属化玻璃/二氧化硅纤维，或者可以与两个或更多个绝缘的金属导电路径同轴。 可以包括柔性聚合物材料的外护套。
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