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公开(公告)号：US6147135A
公开(公告)日：2000-11-14
申请号：US223947
申请日：1998-12-31
IPC分类号： A61B17/00 , A61B17/04 , A61B17/064 , A61B17/08 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/44 , A61F2/82 , A61K9/22 , A61L27/48 , A61L29/12 , A61L31/12 , A61M25/00 , A61M1/06 , A61M11/00
CPC分类号： A61L29/126 , A61F2/30965 , A61L27/48 , A61L31/129 , A61B17/0401 , A61B17/064 , A61B17/08 , A61B2017/00004 , A61B2017/0406 , A61F2/0063 , A61F2/30 , A61F2/3094 , A61F2/442 , A61F2/82 , A61F2002/30004 , A61F2002/30009 , A61F2002/30062 , A61F2002/30622 , A61F2002/30677 , A61F2210/0004 , A61F2250/0014 , A61F2250/0028 , A61F2250/0067 , A61M25/0009 , Y10S525/937
摘要： Composite materials formed from biocompatible polymer fibers and biodegradable polymers are disclosed. The heat treatment conditions for the reinforcing fibers are described so that the mechanical properties of the fibers can be retained during composite consolidation process. The processing conditions and set-ups to consolidations are constrained to the temperatures lower than fiber heat treatment temperatures. The reinforcing fibers are restrained under tension so that the minimum relaxation occurs during consolidation process.
摘要翻译： 公开了由生物相容性聚合物纤维和可生物降解的聚合物形成的复合材料。 描述了增强纤维的热处理条件，使得在复合固结过程中可以保持纤维的机械性能。 加工条件和组合设置被限制在低于纤维热处理温度的温度。 增强纤维在张力下被抑制，使得在固结过程中发生最小的松弛。
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公开(公告)号：US06303697B1
公开(公告)日：2001-10-16
申请号：US09637227
申请日：2000-10-13
IPC分类号： A61K922
CPC分类号： A61L29/126 , A61B17/0401 , A61B17/064 , A61B17/08 , A61B2017/00004 , A61B2017/0406 , A61F2/0063 , A61F2/30 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2/82 , A61F2002/30004 , A61F2002/30009 , A61F2002/30062 , A61F2002/30622 , A61F2002/30677 , A61F2210/0004 , A61F2250/0014 , A61F2250/0028 , A61F2250/0067 , A61L27/48 , A61L31/129 , A61M25/0009 , Y10S525/937 , A61L27/58 , C08L67/04 , A61L31/148
摘要： Composite materials formed from biocompatible polymer fibers and biodegradable polymers are disclosed. The heat treatment conditions for the reinforcing fibers are described so that the mechanical properties of the fibers can be retained during composite consolidation process. The processing conditions and set-ups to consolidations are constrained to the temperatures lower than fiber heat treatment temperatures. The reinforcing fibers are restrained under tension so that the minimum relaxation occurs during consolidation process.
摘要翻译： 公开了由生物相容性聚合物纤维和可生物降解的聚合物形成的复合材料。 描述了增强纤维的热处理条件，使得在复合固结过程中可以保持纤维的机械性能。 加工条件和组合设置被限制在低于纤维热处理温度的温度。 增强纤维在张力下被抑制，使得在固结过程中发生最小的松弛。
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公开(公告)号：US07169187B2
公开(公告)日：2007-01-30
申请号：US10602338
申请日：2003-06-24
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： The present invention is directed to stents that are formed into a helical structure having a plurality of coils, a longitudinal axis, an internal longitudinal passage, a distal section and a proximal section having different diameters; where the structure is made from a fiber having a cross-section and including an inner core having an exterior surface made from a biodegradable polymer having a first degradation rate and an outer section made from a blend of a first biodegradable polymer component and a second biodegradable polymer component covering the exterior surface of the inner core and having a second degradation rate; where the second degradation rate is lower than the first degradation rate.
摘要翻译： 本发明涉及形成具有多个线圈，纵向轴线，内部纵向通道，远端部分和具有不同直径的近端部分的螺旋结构的支架; 其中结构由具有横截面的纤维制成，并且包括具有由具有第一降解速率的生物可降解聚合物制成的外表面的内芯和由第一可生物降解的聚合物组分和第二可生物降解的共混物制成的外部部分 聚合物组分覆盖内芯的外表面并具有第二降解速率; 其中第二降解速率低于第一降解速率。
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公开(公告)号：US07163562B2
公开(公告)日：2007-01-16
申请号：US10059637
申请日：2002-01-29
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a pre-determined period of time through normal flow of body fluids passing through the lumen.
摘要翻译： 用于植入人体内腔的可生物降解支架。 一个实施方案中的支架由具有内芯和外层的生物可降解纤维制成。 外层是两种聚合物组分的混合物。 内核具有第一降解率，外层具有第二降解率。 第二降解速率比第一降解速率慢。 纤维在体内软化，使得支架在通过通过管腔的体液的正常流动在预定时间段之后容易地作为软化碎片或细丝从内腔通过。
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公开(公告)号：US07166134B2
公开(公告)日：2007-01-23
申请号：US10256942
申请日：2002-09-27
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a pre-determined period of time through normal flow of body fluids passing through the lumen.
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公开(公告)号：US06537312B2
公开(公告)日：2003-03-25
申请号：US09933059
申请日：2001-08-20
IPC分类号： A61F206
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a pre-determined period of time through normal flow of body fluids passing through the lumen.
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公开(公告)号：US06981987B2
公开(公告)日：2006-01-03
申请号：US09851257
申请日：2001-05-08
CPC分类号： A61F2/88 , A61F2002/072 , A61F2210/0004 , A61L31/10 , C08L39/06 , C08L71/02 , C08L67/04 , C08L29/04 , C08L33/26
摘要： A removable stent for implantation into a lumen in a human body. The stent is made from a soft, flexible fiber having an outer surface. An outer bioabsorbable/degradable coating is applied to the outer surface of the filament causing it to become rigid. The coating softens in vivo through absorption and/or degradation such that the stent is readily passed or removed from the lumen as a softened filament after a pre-determined period of time through normal flow of body fluids passing through the lumen or by manual removal.
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公开(公告)号：US06494908B1
公开(公告)日：2002-12-17
申请号：US09470620
申请日：1999-12-22
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2002/072 , A61F2210/0004 , A61L31/10 , C08L39/06 , C08L71/02 , C08L67/04 , C08L29/04 , C08L33/26
摘要： A removable stent for implantation into a lumen in a human body. The stent is made from a soft, flexible fiber having an outer surface. An outer bioabsorbable/degradable coating is applied to the outer surface of the filament causing it to become rigid. The coating softens in vivo through absorption and/or degradation such that the stent is readily passed or removed from the lumen as a softened filament after a pre-determined period of time through normal flow of body fluids passing through the lumen or by manual removal.
摘要翻译： 用于植入人体内腔的可拆卸支架。 支架由具有外表面的柔软柔性纤维制成。 将外部生物可吸收/可降解的涂层施加到细丝的外表面上，使其变得刚性。 涂层通过吸收和/或降解在体内软化，使得支架在经过通过管腔的体液的正常流动或通过手动去除之后经预先确定的时间段容易地作为软化丝从内腔中通过或移除。
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公开(公告)号：US06423092B2
公开(公告)日：2002-07-23
申请号：US09933096
申请日：2001-08-20
IPC分类号： A61F206
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a predetermined period of time through normal flow of body fluids passing through the lumen.
摘要翻译： 用于植入人体内腔的可生物降解支架。 一个实施方案中的支架由具有内芯和外层的生物可降解纤维制成。 外层是两种聚合物组分的混合物。 内核具有第一降解率，外层具有第二降解率。 第二降解速率比第一降解速率慢。 纤维在体内软化，使得支架在通过通过管腔的体液的正常流动在预定时间段之后容易地作为软化碎片或细丝从管腔通过。
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公开(公告)号：US06338739B1
公开(公告)日：2002-01-15
申请号：US09470619
申请日：1999-12-22
IPC分类号： A61F206
CPC分类号： A61L31/148 , A61F2/88 , A61F2210/0004 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/14 , C08L67/04
摘要： A biodegradable stent for implantation into a lumen in a human body. The stent in one embodiment is made from a biodegradable fiber having an inner core and an outer layer. The outer layer is a blend of two polymer components. The inner core has a first degradation rate, and the outer layer has a second degradation rate. The second degradation rate is slower than the first degradation rate. The fiber softens in vivo such that the stent is readily passed from the lumen as a softened fragment or filament after a predetermined period of time through normal flow of body fluids passing through the lumen.
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