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    Biocompatible medical devices
    1.
    发明申请
    Biocompatible medical devices 有权
    生物相容性医疗器械

    公开(公告)号：US20070197980A1

    公开(公告)日：2007-08-23

    申请号：US11451634

    申请日：2006-06-12

    申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

    Biocompatible medical devices
    3.
    发明授权
    Biocompatible medical devices 有权
    生物相容性医疗器械

    公开(公告)号：US08808272B2

    公开(公告)日：2014-08-19

    申请号：US11451634

    申请日：2006-06-12

    申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

    IPC分类号： A61M25/00

    CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

    Biocompatible medical devices
    6.
    发明授权
    Biocompatible medical devices 失效
    生物相容性医疗器械

    公开(公告)号：US06638259B1

    公开(公告)日：2003-10-28

    申请号：US09429178

    申请日：1999-10-28

    申请人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

    发明人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

    IPC分类号： A61M2500

    CPC分类号： A61L29/085 ,  A61L2/18 ,  A61L29/08 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L31/10 ,  A61L33/0076 ,  C23C22/50

    摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns numerous modifications to the metallic component that are effective to prevent such a substantial reduction in pharmaceutical effectiveness.

    摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用期间与药物活性物质接触的金属成分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属组分的许多修改，其有效地防止药物效力的显着降低。

    Catheter having a distal drug delivery unit and method of using same
    8.
    发明申请
    Catheter having a distal drug delivery unit and method of using same 失效
    具有远端药物递送单元的导管及其使用方法

    公开(公告)号：US20060200083A1

    公开(公告)日：2006-09-07

    申请号：US11070190

    申请日：2005-03-03

    申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    IPC分类号： A61M5/00

    CPC分类号： A61M25/0082 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  A61M5/1483 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0091

    摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

    摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

    Medical device with drug delivery member
    9.
    发明申请
    Medical device with drug delivery member 失效
    医疗器械配药

    公开(公告)号：US20050043678A1

    公开(公告)日：2005-02-24

    申请号：US10645653

    申请日：2003-08-20

    申请人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    发明人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    IPC分类号： A61M25/00 ,  A61M29/00

    CPC分类号： A61M29/02 ,  A61M25/1029 ,  A61M2025/0057 ,  A61M2025/105

    摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。