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    Catheter having a distal drug delivery unit and method of using same
    4.
    发明申请
    Catheter having a distal drug delivery unit and method of using same 失效
    具有远端药物递送单元的导管及其使用方法

    公开(公告)号：US20060200083A1

    公开(公告)日：2006-09-07

    申请号：US11070190

    申请日：2005-03-03

    申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  Timothy Mickley

    IPC分类号： A61M5/00

    CPC分类号： A61M25/0082 ,  A61M5/14526 ,  A61M5/14593 ,  A61M5/148 ,  A61M5/1483 ,  A61M25/0074 ,  A61M25/0084 ,  A61M2025/0091

    摘要： A catheter having a drug delivery unit at the distal end thereof. The drug delivery unit includes an actuator capable of assuming an activated and an inactivated configuration. The drug delivery unit also includes a receptacle capable of accepting a therapeutic agent. The actuator and receptacle are in communication with each other such that the actuator transmits force to the receptacle and the receptacle accepts force from the actuator in an activated configuration of the actuator. Also provided is a method of delivering a therapeutic agent to a target site using the catheter of the present invention.

    摘要翻译： 一种在其远端具有药物输送单元的导管。 药物递送单元包括能够承受激活和非活化构型的致动器。 药物递送单元还包括能够接受治疗剂的容器。 致动器和容器彼此连通，使得致动器将力传递到插座，并且插座在致动器的激活配置中接受来自致动器的力。 还提供了使用本发明的导管将治疗剂递送到靶位点的方法。

    Medical device with drug delivery member
    5.
    发明申请
    Medical device with drug delivery member 失效
    医疗器械配药

    公开(公告)号：US20050043678A1

    公开(公告)日：2005-02-24

    申请号：US10645653

    申请日：2003-08-20

    申请人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    发明人： Toby Freyman ,  Timothy Mickley ,  Maria Palasis ,  Wendy Naimark

    IPC分类号： A61M25/00 ,  A61M29/00

    CPC分类号： A61M29/02 ,  A61M25/1029 ,  A61M2025/0057 ,  A61M2025/105

    摘要： The present invention generally relates to a medical device for delivering a therapeutic agent to an internal portion of a patient's body. The medical device includes a shaft and a self-expanding delivery member in operative communication with the shaft. The delivery member is shaped from a porous material that is capable of releasing a therapeutic agent to an internal portion of a patient's body. The medical device further includes a therapeutic agent delivery lumen in fluid communication with the delivery member to fluidly connect the delivery member with a therapeutic agent source. A retention member may also be provided to selectively collapse the delivery member.

    摘要翻译： 本发明一般涉及用于将治疗剂递送到患者身体的内部的医疗装置。 该医疗装置包括轴和与该轴可操作地连通的自扩张输送构件。 递送构件由能够将治疗剂释放到患者身体的内部的多孔材料成形。 医疗装置还包括与递送构件流体连通以将递送构件与治疗剂源流体连接的治疗剂递送腔。 还可以设置保持构件以选择性地折叠输送构件。

    Local delivery of therapeutic agent to heart valves
    6.
    发明授权
    Local delivery of therapeutic agent to heart valves 有权
    局部向心脏瓣膜递送治疗剂

    公开(公告)号：US08808364B2

    公开(公告)日：2014-08-19

    申请号：US13240792

    申请日：2011-09-22

    申请人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

    发明人： Maria Palasis ,  Timothy J. Mickley ,  Toby Freyman ,  Wendy Naimark

    IPC分类号： A61F2/06 ,  A61M29/00

    CPC分类号： A61M31/002 ,  A61F2/24 ,  A61F2250/0067

    摘要： The present invention relates to implantable medical devices and methods that employ these medical devices to treat heart valves. In one embodiment, a medical device is provided comprising a body. The body may have a portion thereof including therapeutic agent and can be configured to support the device proximate a heart valve. Methods in accordance with embodiments of the present invention may also include providing a medical device having a body with at least a portion thereof including a therapeutic agent. These methods may also include positioning the medical device in a location proximate to a downstream surface of the heart valve and securing the device. The therapeutic agent released may then be delivered to the heart valve.

    摘要翻译： 本发明涉及使用这些医疗装置来治疗心脏瓣膜的可植入医疗装置和方法。 在一个实施例中，提供了包括身体的医疗装置。 身体可以具有其一部分，包括治疗剂，并且可被构造成在靠近心脏瓣膜的位置支撑装置。 根据本发明的实施例的方法还可以包括提供具有身体的医疗装置，其中至少一部分包括治疗剂。 这些方法还可以包括将医疗装置定位在靠近心脏瓣膜的下游表面的位置并固定装置。 然后释放的治疗剂可以被递送到心脏瓣膜。

    Device and method for delivering micronized therapeutic agents in the body
    7.
    发明授权
    Device and method for delivering micronized therapeutic agents in the body 失效
    在体内递送微粉治疗剂的装置和方法

    公开(公告)号：US07892205B2

    公开(公告)日：2011-02-22

    申请号：US10455298

    申请日：2003-06-06

    申请人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

    发明人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

    IPC分类号： A61M37/00

    CPC分类号： A61M11/06 ,  A61M25/0054 ,  A61M2025/0057

    摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

    摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

    Delivery of therapeutic through multiple delivery members
    8.
    发明授权
    Delivery of therapeutic through multiple delivery members 有权
    通过多个递送成员递送治疗

    公开(公告)号：US07517338B2

    公开(公告)日：2009-04-14

    申请号：US11038241

    申请日：2005-01-21

    申请人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  William J. Shaw

    发明人： Toby Freyman ,  Maria Palasis ,  Wendy Naimark ,  William J. Shaw

    IPC分类号： A61M25/00 ,  A61M29/00

    CPC分类号： A61M25/0068 ,  A61B2017/00247 ,  A61B2018/00392 ,  A61M25/0071 ,  A61M25/0074 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0058 ,  A61M2025/0076 ,  A61M2025/0079 ,  A61M2025/0085 ,  A61M2025/0681

    摘要： Embodiments of the present invention regard the delivery of therapeutic. One such apparatus may comprise multiple, independently-activated, injection devices for the delivery of therapeutic or other substances. This apparatus may include a first catheter; a second catheter in the first catheter and a multiple delivery member injection device. This multiple delivery member may include an expandable member and a plurality of injection elements. A third catheter may be positioned in the second catheter. This third catheter may have a distal end connected to a wall of the expandable member and a plurality of filling tubes connected to an distal end of the third catheter. In some of the embodiments each of the injection elements may hold a pressurized therapeutic prior to release of the therapeutic.

    摘要翻译： 本发明的实施方案涉及治疗的递送。 一种这样的装置可以包括用于递送治疗剂或其它物质的多个独立激活的注射装置。 该装置可以包括第一导管; 第一导管中的第二导管和多个递送部件注射装置。 该多个传送构件可以包括可扩张构件和多个注射元件。 第三导管可以定位在第二导管中。 该第三导管可以具有连接到可扩张构件的壁的远端和连接到第三导管的远端的多个填充管。 在一些实施方案中，每个注射元件可以在释放治疗剂之前保持加压治疗。

    Medical device for delivering patches
    9.
    发明授权
    Medical device for delivering patches 有权
    用于传送补丁的医疗设备

    公开(公告)号：US07481788B2

    公开(公告)日：2009-01-27

    申请号：US11076552

    申请日：2005-03-09

    申请人： Wendy Naimark ,  Maria Palasis

    发明人： Wendy Naimark ,  Maria Palasis

    IPC分类号： A61M31/00 ,  A61B17/08

    CPC分类号： A61M37/0015 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/205 ,  A61B17/221 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00615 ,  A61B2017/00623 ,  A61B2017/00893 ,  A61B2017/2212 ,  A61B2018/00392 ,  A61F2/2481 ,  A61F2002/2484 ,  A61F2250/0067 ,  B33Y80/00

    摘要： The present invention relates to a medical device and method for treating the body tissue of a patient. The present invention is also directed to a method of making the medical device and a method of using the medical device. More particularly, the invention relates to a medical device which is inserted into the body for delivery of therapeutic patches to the surface of a body lumen, organ or cavity. In one embodiment, the medical device comprises an elongated member; an umbrella-like expandable assembly which has a plurality of wire elements; and a therapeutic patch. In another embodiment, the medical device comprises an elongated member, a basket-like expandable assembly having a plurality of wire elements; and a therapeutic patch.

    摘要翻译： 本发明涉及用于治疗患者的身体组织的医疗装置和方法。 本发明还涉及制造医疗装置的方法和使用该医疗装置的方法。 更具体地，本发明涉及一种医疗装置，其被插入到体内，用于将治疗性补片递送到体腔，器官或空腔的表面。 在一个实施例中，医疗装置包括细长构件; 具有多个线元件的伞形可扩展组件; 和治疗补片。 在另一个实施例中，医疗装置包括细长构件，具有多个线元件的篮状可扩展组件; 和治疗补片。

    Multiple needle injection catheter
    10.
    发明授权
    Multiple needle injection catheter 有权
    多针注射导管

    公开(公告)号：US07442187B2

    公开(公告)日：2008-10-28

    申请号：US11051638

    申请日：2005-01-27

    申请人： Inas Khayal ,  Wendy Naimark ,  Maria Palasis

    发明人： Inas Khayal ,  Wendy Naimark ,  Maria Palasis

    IPC分类号： A61M5/178

    CPC分类号： A61M25/0084

    摘要： Embodiments of the present invention relate to multiple needle catheter-based injection systems to deliver a plug of a therapeutic or other agent. A medical device may include a catheter with a distal end, a proximal end and a catheter lumen extending therebetween and an outer needle disposed in the catheter lumen with a distal end and a proximal end and an outer needle lumen extending therebetween. The medical device may include an inner needle with a distal end and a proximal end, the inner needle being disposed in the outer needle lumen and the distal end of the inner needle to receive and hold a therapeutic plug, and a needle control mechanism coupled to the proximal ends of the outer needle and the inner needle, the needle control mechanism to independently and jointly control ejection and retraction of the outer and inner needles to deliver the therapeutic plug into a target tissue site.

    摘要翻译： 本发明的实施例涉及用于递送治疗剂或其它药剂的塞子的多针导管基注射系统。 医疗装置可以包括具有远端，近端和在其间延伸的导管内腔的导管，以及设置在导管内腔中的外针，其具有在其间延伸的远端和近端以及外针管腔。 医疗装置可以包括具有远端和近端的内针，内针设置在外针内腔中并且内针的远端以接收和保持治疗塞，以及针控制机构，其联接到 外针和内针的近端，针控制机构独立地并且共同地控制外针和内针的弹出和缩回，以将治疗栓输送到目标组织部位。