公开(公告)号：US08808272B2

公开(公告)日：2014-08-19

申请号：US11451634

申请日：2006-06-12

申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

IPC分类号： A61M25/00

CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

公开(公告)号：US20070197980A1

公开(公告)日：2007-08-23

申请号：US11451634

申请日：2006-06-12

申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg

IPC分类号： A61M25/00

CPC分类号： A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L31/10

摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

公开(公告)号：US06638259B1

公开(公告)日：2003-10-28

申请号：US09429178

申请日：1999-10-28

申请人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

发明人： Maria Palasis ,  Louis Ellis ,  Timothy Mickley

IPC分类号： A61M2500

CPC分类号： A61L29/085 ,  A61L2/18 ,  A61L29/08 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L31/10 ,  A61L33/0076 ,  C23C22/50

摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns numerous modifications to the metallic component that are effective to prevent such a substantial reduction in pharmaceutical effectiveness.

摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用期间与药物活性物质接触的金属成分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属组分的许多修改，其有效地防止药物效力的显着降低。

公开(公告)号：US07060056B2

公开(公告)日：2006-06-13

申请号：US10909930

申请日：2004-08-02

申请人： Maria Palasis ,  Wendy Naimark ,  Timothy Mickley ,  Louis Ellis

发明人： Maria Palasis ,  Wendy Naimark ,  Timothy Mickley ,  Louis Ellis

IPC分类号： A61M25/00 ,  A61M5/32

CPC分类号： A61L31/10 ,  A61L2/18 ,  A61L29/08 ,  A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L31/088 ,  A61L33/0076

摘要： Many conventional pharmaceutical articles contain seemingly inert components that come into contact with a pharmaceutically active material during use, which contact substantially reduces the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to these incompatible components, which are effective to diminish the reduction in pharmaceutical effectiveness.

公开(公告)号：US20050113767A1

公开(公告)日：2005-05-26

申请号：US10909930

申请日：2004-08-02

申请人： Maria Palasis ,  Wendy Naimark ,  Timothy Mickley ,  Louis Ellis

发明人： Maria Palasis ,  Wendy Naimark ,  Timothy Mickley ,  Louis Ellis

IPC分类号： A61L29/00 ,  A61F2/84 ,  A61L2/18 ,  A61L29/08 ,  A61L29/10 ,  A61L29/14 ,  A61L31/00 ,  A61L31/08 ,  A61L31/10 ,  A61L33/00 ,  A61M5/178 ,  A61M25/00 ,  A61M5/00

CPC分类号： A61L31/10 ,  A61L2/18 ,  A61L29/08 ,  A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L31/088 ,  A61L33/0076

摘要： Many conventional pharmaceutical articles contain seemingly inert components that come into contact with a pharmaceutically active material during use, which contact substantially reduces the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to these incompatible components, which are effective to diminish the reduction in pharmaceutical effectiveness.

摘要翻译： 许多常规药物制品含有在使用期间与药物活性物质接触的看似惰性的成分，该接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对这些不相容组分的各种修改，其有效减少药物效力的降低。

公开(公告)号：US06663606B1

公开(公告)日：2003-12-16

申请号：US09503586

申请日：2000-02-14

申请人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg ,  Justin Crank

发明人： James Barry ,  Maria Palasis ,  Louis Ellis ,  Timothy Mickley ,  Brian Berg ,  Justin Crank

IPC分类号： A61M2500

CPC分类号： A61L31/10 ,  A61L2/18 ,  A61L29/08 ,  A61L29/085 ,  A61L29/103 ,  A61L29/106 ,  A61L29/14 ,  A61L29/16 ,  A61L31/16 ,  A61L33/0076 ,  A61L2300/00 ,  C23C22/50

摘要： A modified medical device for delivery of a pharmaceutically active material is described. The present inventors have found that many conventional medical devices contain a metallic or polymeric component that comes into contact with a pharmaceutically active material during use, and that the contact substantially reduce the pharmaceutical effectiveness of the pharmaceutically active material. The invention described herein concerns various modifications to the metallic or polymeric component that are effective to diminish such a substantial reduction in pharmaceutical effectiveness.

摘要翻译： 描述了用于递送药物活性物质的改进的医疗装置。 本发明人已经发现许多常规医疗器械含有在使用过程中与药物活性物质接触的金属或聚合物组分，并且接触显着降低了药物活性物质的药物有效性。 本文描述的发明涉及对金属或聚合物组分的各种修饰，其有效地减少药物有效性的这种显着降低。

公开(公告)号：US20050256450A1

公开(公告)日：2005-11-17

申请号：US11185801

申请日：2005-07-21

申请人： Maria Palasis ,  James Barry ,  Louis Ellis ,  Gary Hendrickson ,  Kent Harrison ,  Lixiao Wang

发明人： Maria Palasis ,  James Barry ,  Louis Ellis ,  Gary Hendrickson ,  Kent Harrison ,  Lixiao Wang

IPC分类号： A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00 ,  A61F2/02 ,  A61L29/16 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/320084 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/2493 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/64 ,  A61M25/0084 ,  A61M37/0069 ,  A61M2025/0004 ,  A61M2025/0089

摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.

摘要翻译： 提供了用于放置原位植入物的导管。 该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端 设置在第二轴的远端。 根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。 此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

公开(公告)号：US07854743B2

公开(公告)日：2010-12-21

申请号：US11185801

申请日：2005-07-21

申请人： Maria Palasis ,  James J. Barry ,  Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang

发明人： Maria Palasis ,  James J. Barry ,  Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang

IPC分类号： A61B17/32

CPC分类号： A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/320084 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/2493 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/64 ,  A61M25/0084 ,  A61M37/0069 ,  A61M2025/0004 ,  A61M2025/0089

摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.

摘要翻译： 提供了用于放置原位植入物的导管。 该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端 设置在第二轴的远端。 根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。 此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

公开(公告)号：US06953466B2

公开(公告)日：2005-10-11

申请号：US10837612

申请日：2004-05-04

申请人： Maria Palasis ,  James J. Barry ,  Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang

发明人： Maria Palasis ,  James J. Barry ,  Louis Ellis ,  Gary L. Hendrickson ,  Kent D. Harrison ,  Lixiao Wang

IPC分类号： A61B17/00 ,  A61B17/32 ,  A61B17/34 ,  A61B19/00 ,  A61F2/02 ,  A61L29/16 ,  A61M25/00 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61B17/3468 ,  A61B17/3478 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/320084 ,  A61B2018/00392 ,  A61B2018/1425 ,  A61F2/2493 ,  A61L29/16 ,  A61L2300/258 ,  A61L2300/414 ,  A61L2300/64 ,  A61M25/0084 ,  A61M37/0069 ,  A61M2025/0004 ,  A61M2025/0089

摘要： A method for delivering a therapeutic implant to a tissue is provided. This method includes providing an elongate catheter having a distal end including a lumen, providing a carrier including a therapeutic agent, placing the carrier including the therapeutic agent into the lumen, advancing the distal end of the catheter to the tissue, and depositing the carrier including the therapeutic agent into the tissue.

摘要翻译： 提供了将治疗性植入物递送到组织的方法。 该方法包括提供细长的导管，其具有包括内腔的远端，提供包括治疗剂的载体，将包括治疗剂的载体放置在内腔中，将导管的远端推进到组织，以及沉积载体，包括 治疗剂进入组织。

公开(公告)号：US06416490B1

公开(公告)日：2002-07-09

申请号：US09035736

申请日：1998-03-05

申请人： Louis Ellis ,  Gary L. Hendrickson ,  Lauri DeVore

发明人： Louis Ellis ,  Gary L. Hendrickson ,  Lauri DeVore

IPC分类号： A61B1720

CPC分类号： A61B18/1492 ,  A61B17/3468 ,  A61B17/3478 ,  A61B18/1477 ,  A61B90/39 ,  A61B2017/00247 ,  A61B2017/00296 ,  A61B2017/00867 ,  A61B2017/320084 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00279 ,  A61B2018/00392 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2018/162 ,  A61B2218/002 ,  A61F2/2493 ,  A61M2025/0089

摘要： A catheter having an elongate shaft including a proximal and a distal end. The shaft includes a conductor. An electrode is disposed at the distal end of the shaft and is connected to the conductor. The electrode has a generally annular, cross-sectional shape. The annular shape defines an opening within the electrode. An insulator surrounds the conductor. In accordance with the method of the present invention, a crater wound can be formed through the endocardium and into the myocardium of a patient's heart. Collateral damage to the myocardium can be made by infusing pressurized fluid into the crater wound.