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    Analyte detection system with interferent identification and correction
    2.
    发明申请
    Analyte detection system with interferent identification and correction 审中-公开
    分析物检测系统具有干扰物识别和校正

    公开(公告)号：US20070103678A1

    公开(公告)日：2007-05-10

    申请号：US11314803

    申请日：2005-12-21

    申请人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    发明人： Bernhard Sterling ,  W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Richard Keenan ,  Richard King

    IPC分类号： G01J3/00

    CPC分类号： A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

    摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient. The apparatus further comprises a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer configured to obtain spectra from at least a portion of the sample, and a processor in communication with or incorporated into the spectroscopic analyzer. The apparatus further comprises stored program instructions executable by the processor to (a) identify one or more interferents to the measurement of one or more analytes in the bodily fluid as being possibly present in the portion, and (b) reduce errors in the measurement due to the presence of the determined possible interferents. The pump unit can comprise a single dual-mode or reversible pump operable in both the infusion and sample draw modes; or two pumps, one of which is operable in the infusion mode but not in the sample draw mode, and another of which is operable in the sample draw mode but not in the infusion mode.

    摘要翻译： 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端。 该装置还包括与流体处理网络有效接合的泵单元。 泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过 病人结束 该装置还包括分光分析器，被配置为从样品的至少一部分获得光谱，以及与光谱分析仪连通或结合到光谱分析仪中的处理器。 所述装置还包括可由所述处理器执行的存储的程序指令，以（a）识别对所述部分中可能存在的所述体液中的一种或多种分析物的测量的一个或多个干扰物，以及（b）减少所述测量中的误差 确定可能的干扰物的存在。 泵单元可以包括可在输液和抽样模式中操作的单个双模式或可逆泵; 或两个泵，其中一个可在输液模式中操作，但不在样品抽取模式中，另一个在样品抽取模式中可操作，但不在输注模式中。

    Apparatus and methods for analyzing body fluid samples
    4.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20070060872A1

    公开(公告)日：2007-03-15

    申请号：US11352956

    申请日：2006-02-13

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00 ,  A61D5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Apparatus and methods for analyzing body fluid samples
    5.
    发明申请
    Apparatus and methods for analyzing body fluid samples 审中-公开

    公开(公告)号：US20060189926A1

    公开(公告)日：2006-08-24

    申请号：US11316407

    申请日：2005-12-21

    申请人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    发明人： W. Hall ,  David Callicoat ,  Jennifer Gable ,  James Braig ,  Kenneth Witte ,  Mark Wechsler ,  Peter Rule ,  Richard Keenan

    IPC分类号： A61M31/00 ,  A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M2230/20

    摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

    Analyte detection system
    10.
    发明申请
    Analyte detection system 审中-公开
    分析物检测系统

    公开(公告)号：US20050037384A1

    公开(公告)日：2005-02-17

    申请号：US10824946

    申请日：2004-04-15

    申请人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    发明人： James Braig ,  Michael Munrow ,  Kenneth Witte ,  Mark Wechsler ,  Jennifer Gable ,  Igor Nemchuk ,  Peng Zheng ,  Kenneth Li ,  Maria Isaac ,  Robert Gaffney ,  Ronald Leguidleguid ,  Fiona Sander

    IPC分类号： G01N21/03 ,  G01N21/35 ,  G01N21/86 ,  C12Q1/68 ,  C12M1/34

    CPC分类号： G01N21/8483 ,  G01N21/0303 ,  G01N21/35 ,  G01N21/3577

    摘要： Disclosed herein is a system for estimating the concentration of an analyte in a material sample. The system comprises a source of electromagnetic radiation; a detector positioned to detect radiation emitted by the source, so that the source and the detector define an optical path therebetween; and a sample element configured to be positioned in the optical path. The sample element comprises a sample chamber at least partially defined by opposed first and second windows which are substantially transmissive of at least a portion of the radiation emitted by the source, and which define an optical pathlength through the sample element. The sample chamber has an internal volume of less than 2 microliters. When the material sample is positioned in the sample chamber and the sample chamber is positioned in the optical path, the system computes estimated concentrations of the analyte in the material sample. The estimated concentrations deviate from corresponding actual concentrations of the analyte in the material sample by an RMS error of less than 15 mg/dL.

    摘要翻译： 本文公开了一种用于估计材料样品中分析物浓度的系统。 该系统包括电磁辐射源; 检测器，定位成检测由源发射的辐射，使得源和检测器在其间限定光路; 以及构造成定位在光路中的样本元件。 样品元件包括至少部分地由相对的第一和第二窗口限定的样品室，其基本上透射由源发射的辐射的至少一部分，并且通过样品元件限定光程长度。 样品室的体积小于2微升。 当材料样品定位在样品室中并且样品室位于光路中时，系统计算材料样品中分析物的估计浓度。 估计的浓度偏离材料样品中分析物的相应实际浓度，RMS误差小于15 mg / dL。