公开(公告)号：US08053574B2

公开(公告)日：2011-11-08

申请号：US12669536

申请日：2008-07-16

Applicant: Ian Bruce ,  Darren Mark Legrand ,  James Dale ,  Thomas Anthony Hunt

Inventor： Ian Bruce ,  Darren Mark Legrand ,  James Dale ,  Thomas Anthony Hunt

IPC: C07D487/00 ,  C07D514/14 ,  C07D513/14 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/4436 ,  A61K31/444 ,  A01N43/54 ,  A61K31/4439

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Abstract translation: 磷脂酰肌醇（PI）3-激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂组合的新化合物在预防或治疗以生长因子，蛋白质丝氨酸/苏氨酸激酶和磷脂激酶异常活性为特征的增殖性疾病中的用途。

公开(公告)号：US20070114178A1

公开(公告)日：2007-05-24

申请号：US11287579

申请日：2005-11-23

Applicant: Edward Coppola ,  John Baxley ,  Andrea Davis ,  Francis Boodoo ,  William Fries ,  James Dale

Inventor： Edward Coppola ,  John Baxley ,  Andrea Davis ,  Francis Boodoo ,  William Fries ,  James Dale

IPC: B01D15/00

CPC classification number: B01J49/57 ,  B01J41/07 ,  C02F2301/043

Abstract: The invention consists of a water treatment process using selective and regenerable weak base anion exchange resins to remove any number of complex anions, especially oxyanions including perchlorate, nitrate, chlorate, arsenate, selenate, and chromate, from aqueous solutions. The treatment process is comprised of three key processes including 1) pretreatment to lower pH, 2) ion exchange, and 3) post treatment to adjust pH and alkalinity. The invention also includes processes for regenerating weak base anion resins and treatment of the residuals generated. This invention employs pressurized treatment, carbon dioxide management, and reuse of regenerating solution to minimize pumping and treatment costs.

Abstract translation: 本发明包括使用选择性和可再生的弱碱性阴离子交换树脂从水溶液中除去任何数量的复合阴离子，特别是包括高氯酸盐，硝酸盐，氯酸盐，砷酸盐，硒酸盐和铬酸盐在内的含氧阴离子的水处理方法。 处理过程由三个关键过程组成，包括1）预处理以降低pH值，2）离子交换，以及3）后处理以调节pH值和碱度。 本发明还包括用于再生弱碱性阴离子树脂和处理生成的残余物的方法。 本发明采用加压处理，二氧化碳管理和再生溶液的再利用以最小化泵送和处理成本。

公开(公告)号：US20060274303A1

公开(公告)日：2006-12-07

申请号：US11432766

申请日：2006-05-12

Applicant: David Jackson ,  Brian Gray ,  Steven Rogers ,  Stephen Glickman ,  George Gill ,  James Dale

Inventor： David Jackson ,  Brian Gray ,  Steven Rogers ,  Stephen Glickman ,  George Gill ,  James Dale

IPC: G01C1/00 ,  G01B11/26 ,  G01B5/24 ,  G01B5/00

CPC classification number: G01B11/2755 ,  G01B2210/143 ,  G01B2210/28

Abstract: In a vehicle alignment system an optical sensing mechanism is structurally coupled to a vehicle supporting lift for movement in unison with the lift so that the field of view of the sensing mechanism encompasses a wheel of a vehicle positioned on the lift during lift movement. Sensing modules may be selectively placed so that they are in correspondence with the vehicle wheel base. Modules may be deployed to extend outwardly from the lift, for viewing the wheel during an alignment procedure, or retract to a adjacent the lift for stowing. A protective cover extends above the sensing modules in the retracted position.

Abstract translation: 在车辆对准系统中，光学感测机构在结构上耦合到车辆支撑升降机以与升降机一致运动，使得感测机构的视野包括在升降运动期间位于升降机上的车辆的车轮。 可以选择性地放置感测模块，使得它们与车轮基座对应。 模块可以被部署成从升降机向外延伸，以便在对准过程期间观察车轮，或者缩回到相邻的升降机以进行收起。 保护盖在缩回位置上延伸到感测模块的上方。

公开(公告)号：US20050268707A1

公开(公告)日：2005-12-08

申请号：US10859151

申请日：2004-06-03

Applicant: James Dale ,  Wen Zhou ,  Frederick Rogers

Inventor： James Dale ,  Wen Zhou ,  Frederick Rogers

IPC: G01B11/22 ,  G01M17/02 ,  E01C23/00

CPC classification number: G01M17/027 ,  G01B11/22

Abstract: A non-contact method and system for analyzing tire conditions. The system includes an emitter source for emitting radiation signals towards a tire having a treaded surface between two sidewalls. A detector is provided to receive signals reflected by the tire in response to the emitted radiation signals. A data processing system, coupled to the emitter source and the detector, obtains geometrical information, such as height, of a plurality points on the tire based on the signals received from the detector. The data processing system determines a condition of the tire by comparing geometrical information for a designated portion of the plurality points with other portion points on the tire. A color-coded surface profile showing a height distribution of the tire is also generated to assist diagnosis of the tire.

Abstract translation: 用于分析轮胎状况的非接触方法和系统。 该系统包括用于向具有两个侧壁之间的踏面的轮胎发射辐射信号的发射源。 提供检测器以响应于所发射的辐射信号接收由轮胎反射的信号。 耦合到发射源和检测器的数据处理系统基于从检测器接收的信号，获得轮胎上的多个点的几何信息，例如高度。 数据处理系统通过将多个点的指定部分的几何信息与轮胎上的其他部分点进行比较来确定轮胎的状况。 还产生了显示轮胎高度分布的颜色编码的表面轮廓，以辅助轮胎的诊断。

公开(公告)号：US20050102711A1

公开(公告)日：2005-05-12

申请号：US10451889

申请日：2001-12-28

Applicant: James Dale ,  Robert Maxwell Harding ,  Scott Hermann

Inventor： James Dale ,  Robert Maxwell Harding ,  Scott Hermann

IPC: C07K14/415 ,  C12N15/29 ,  C12N15/82 ,  C12Q1/68 ,  A01H1/00

CPC classification number: C07K14/415 ,  C12N15/8216

Abstract: The present invention is directed to the isolation and identification of a non-graminaceous monocotyledonous plant promoter, the banana (Musa.Spp.) actinn gene associated promoter region. The promoter region has been found to unexpectedly direct constitutive gene expression not only in non-graminaceous monocotyledonous plants but also in graminaceous monocotydonous plants. The Invention is also concerned with a chimeric nucleic acid construct comprising the promoter of the invention oprably linked to a foreign or endogenous polynucleotide encoding a protein of interest or a transcript capable of modulating expression of a target gene. The invention further discloses transformed plant cells, as well as differentiated plants and plant parts, containing the construct.

Abstract translation: 本发明涉及非禾本腺单子叶植物启动子，香蕉（Musa.Spp。）actinn基因相关启动子区域的分离和鉴定。 已经发现启动子区域不仅在非禾本类单子叶植物中而且在禾本科单子叶植物中意外地指导组成型基因表达。 本发明还涉及包含可编码感兴趣的蛋白质的外源或内源多核苷酸的本发明启动子的嵌合核酸构建体或能够调节靶基因表达的转录物。 本发明还公开了转化的植物细胞，以及含有该构建体的分化植物和植物部分。

公开(公告)号：US20050027473A1

公开(公告)日：2005-02-03

申请号：US10864879

申请日：2004-06-10

Applicant: Niall Davidson ,  James Dale ,  Eric Bryan

Inventor： Niall Davidson ,  James Dale ,  Eric Bryan

IPC: G01B11/275 ,  G01C9/00

CPC classification number: G01B11/275 ,  G01B2210/20 ,  G01B2210/26 ,  G01B2210/28 ,  G01B2210/283

Abstract: Methods and systems for measuring and calculating wheel alignment angles are disclosed. The measuring methods include mitigating alignment error by compensating for wheel runout, and further include measuring wheel runout while the wheel maintains contact with an alignment surface.

Abstract translation: 公开了用于测量和计算轮对准角的方法和系统。 测量方法包括通过补偿车轮跳动来减轻对准误差，并且还包括当车轮保持与对准表面接触时测量车轮跳动。

公开(公告)号：US08546416B2

公开(公告)日：2013-10-01

申请号：US13479596

申请日：2012-05-24

Applicant: Ameet Vijay Ambarkhane ,  Gurdip Bhalay ,  Martin Beckett ,  James Dale ,  Ahmed Hamadi ,  Alessandro Mazzacani ,  Jeffrey McKenna ,  Christopher Thomson

Inventor： Ameet Vijay Ambarkhane ,  Gurdip Bhalay ,  Martin Beckett ,  James Dale ,  Ahmed Hamadi ,  Alessandro Mazzacani ,  Jeffrey McKenna ,  Christopher Thomson

IPC: C07D211/00 ,  C07D213/00 ,  C07D215/00 ,  C07D219/00 ,  C07D221/00 ,  C07D217/00

CPC classification number: C07D471/10 ,  A61K31/407 ,  A61K31/435 ,  A61K31/55 ,  A61K45/06 ,  C07D487/10

Abstract: The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a disorder or a disease mediated by the ghrelin receptor.

Abstract translation: 本发明涉及式（I）的衍生物，其中取代基如说明书中所定义; 制备此类衍生物的方法; 包含这些衍生物的药物组合物; 这种衍生物作为药物; 用于治疗疾病或由生长素释放肽受体介导的疾病的衍生物。

公开(公告)号：US20100075965A1

公开(公告)日：2010-03-25

申请号：US12279148

申请日：2007-02-14

Applicant: Zhi-Jie Ni ,  Sabina Pecchi ,  Matthew Burger ,  Wooseok Han ,  Aaron Smith ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Joelle Verhagen ,  Yanchen Zhang ,  Ed Iwanowicz ,  Tom Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Darren Mark Legrand ,  Ian Bruce ,  James Dale ,  Jiong Lan ,  Barry Levine ,  Abran Costales ,  Jui Liu ,  Teresa Pick ,  Daniel Menezes

Inventor： Zhi-Jie Ni ,  Sabina Pecchi ,  Matthew Burger ,  Wooseok Han ,  Aaron Smith ,  Gordana Atallah ,  Sarah Bartulis ,  Kelly Frazier ,  Joelle Verhagen ,  Yanchen Zhang ,  Ed Iwanowicz ,  Tom Hendrickson ,  Mark Knapp ,  Hanne Merritt ,  Charles Voliva ,  Marion Wiesmann ,  Darren Mark Legrand ,  Ian Bruce ,  James Dale ,  Jiong Lan ,  Barry Levine ,  Abran Costales ,  Jui Liu ,  Teresa Pick ,  Daniel Menezes

IPC: A61K31/5377 ,  C07D471/04 ,  C07D487/04 ,  C07D413/14 ,  A61K31/437 ,  A61K31/5025 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

Abstract: Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.

Abstract translation: 磷脂酰肌醇（PI）3激酶抑制剂化合物，其药学上可接受的盐和前药; 单独或与至少一种另外的治疗剂组合的新化合物与药学上可接受的载体的组合物; 以及单独或与至少一种另外的治疗剂联合使用的新化合物在预防或治疗以生长因子，蛋白丝氨酸/苏氨酸激酶，磷脂激酶，G蛋白偶联的异常活性为特征的增殖性疾病中的用途 受体和磷酸酶。

公开(公告)号：US20080108968A1

公开(公告)日：2008-05-08

申请号：US11926646

申请日：2007-10-29

Applicant: Jason Demers ,  David McGill ,  Brian Tracey ,  James Dale ,  Larry Gray

Inventor： Jason Demers ,  David McGill ,  Brian Tracey ,  James Dale ,  Larry Gray

IPC: A61B19/00

CPC classification number: A61M5/162 ,  A61M1/0281 ,  A61M5/1626 ,  A61M2205/12

Abstract: An apparatus for use in a fluid processing system having a pump. The apparatus includes a pump cassette for use with the pump. The pump cassette includes at least one pump chamber and a first port in selective fluid communication with the at least one pump chamber. A spiking assembly includes at least one hollow spike having a piercing end for piercing a first container. The at least one hollow spike includes a first spike in fluid communication with the first port of the pump cassette.

Abstract translation: 一种用于具有泵的流体处理系统的装置。 该装置包括与泵一起使用的泵盒。 所述泵盒包括至少一个泵室和与所述至少一个泵室选择性流体连通的第一端口。 尖峰组件包括至少一个具有穿刺端部以刺穿第一容器的中空尖钉。 所述至少一个中空尖钉包括与所述泵盒的所述第一端口流体连通的第一尖峰。

公开(公告)号：US20060130264A1

公开(公告)日：2006-06-22

申请号：US11298792

申请日：2005-12-09

Applicant: Dennis Futo ,  Scott Pyle ,  Michael Sherman ,  James Dale

Inventor： Dennis Futo ,  Scott Pyle ,  Michael Sherman ,  James Dale

IPC: B05C21/00

CPC classification number: B44D3/126

Abstract: A paint tray system is configured to dispense paint onto a paint roller. The paint tray system includes a paint tray having a bottom section, an end wall and side walls forming a reservoir for holding paint. A paint limiter panel is received by the tray overlaying the reservoir in the paint tray, the limiter panel having at least one opening therein to allow paint to flow from the reservoir through the limiter panel. The paint tray system also includes at least one biasing member positioned within the reservoir configured to bias the limiter panel upwardly and away from the bottom section of the tray and thus the surface of the paint within the reservoir.

Abstract translation: 油漆盘系统被配置为将油漆分配到油漆辊上。 油漆盘系统包括具有底部，端壁和形成用于保持油漆的储存器的侧壁的油漆盘。 涂料限制器面板由覆盖在油漆盘中的储存器的托盘接收，限制器板在其中具有至少一个开口，以允许油漆从储存器流过限制器板。 油漆盘系统还包括定位在储存器内的至少一个偏置构件，该偏置构件构造成将限位板向上偏置并远离托盘的底部部分，从而将油漆表面置于储存器内。