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    Orally bioavailable compounds and methods for inhibiting platelet aggregation
    1.
    发明申请
    Orally bioavailable compounds and methods for inhibiting platelet aggregation 失效
    口服生物可利用的化合物和抑制血小板聚集的方法

    公开(公告)号：US20070093446A1

    公开(公告)日：2007-04-26

    申请号：US11595837

    申请日：2006-11-09

    申请人： James Douglass ,  Paul Watson ,  Carl Samuelson ,  Christopher Crean

    发明人： James Douglass ,  Paul Watson ,  Carl Samuelson ,  Christopher Crean

    IPC分类号： A61K31/7076 ,  A61K31/52 ,  C07H19/16 ,  C07D473/02

    CPC分类号： A61K31/519 ,  A61F2250/0067 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7076 ,  A61K31/727 ,  A61K45/06 ,  C07H19/16 ,  A61K2300/00

    摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae III, IIIa, and IIIb, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae IIIa and IIIb, which are potent and have a good oral bioavailability.

    摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式III，IIIa和IIIb的化合物，或其盐，水合物和溶剂化物。 本发明还提供新的式IIIa和IIIb化合物，它们是有效的并且具有良好的口服生物利用度。

    Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation
    4.
    发明申请
    Pyrimidine-based non-nucleotide composition and method for inhibiting platelet aggregation 失效
    基于嘧啶的非核苷酸组合物和抑制血小板聚集的方法

    公开(公告)号：US20060258614A1

    公开(公告)日：2006-11-16

    申请号：US11413600

    申请日：2006-04-28

    申请人： James Douglass ,  Paul Watson ,  Sammy Shaver ,  Krzysztof Bednarski

    发明人： James Douglass ,  Paul Watson ,  Sammy Shaver ,  Krzysztof Bednarski

    IPC分类号： A61K31/7072 ,  A61K31/513 ,  C07H19/12 ,  C07D405/02

    CPC分类号： C07D493/04 ,  C07D405/04 ,  C07H19/12

    摘要： This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide pyrimidine-based compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and Ia-Ic, or tautomers, salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and Ia-Ic.

    摘要翻译： 本发明涉及一种预防或治疗与血小板聚集有关的疾病或病症的方法。 该方法还涉及治疗血栓形成或相关病症的方法。 该方法包括向受试者施用包含有效量的非核苷酸嘧啶类化合物，优选P2Y 12受体拮抗剂化合物的药物组合物，其中所述量有效抑制血小板聚集。 可用于本发明的化合物包括通式I和Ia-Ic的化合物，或其互变异构体，盐，水合物和溶剂合物。 本发明还提供式I和Ia-1c的新型化合物。

    Nucleic acid-based method for tree phenotype prediction: dna markers for fibre coarseness, microfibril angle, pulp strength and yield, lignin content, pitch propensity and calcium accumulation determinants
    6.
    发明申请
    Nucleic acid-based method for tree phenotype prediction: dna markers for fibre coarseness, microfibril angle, pulp strength and yield, lignin content, pitch propensity and calcium accumulation determinants 审中-公开
    用于树表型预测的基于核酸的方法：用于纤维粗糙度，微纤丝角度，纸浆强度和产量，木质素含量，沥青倾向和钙累积决定簇的dna标记

    公开(公告)号：US20050037350A1

    公开(公告)日：2005-02-17

    申请号：US10481697

    申请日：2002-06-25

    申请人： Simon Potter ,  Paul Watson

    发明人： Simon Potter ,  Paul Watson

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156

    摘要： The present invention relates to methods for identifying individual trees having a superior phenotype and more particularly to molecular markers and/or quantitative trait loci (QTL) which can be used to identify individual trees having a superior phenotype. The molecular markers and/or QTL comprise restriction fragment length polymorphism pattern or PCR-fingerprint. The molecular markers and/or QTL can be used for the development of marker-assisted breeding, rapid assessment techniques or to identify orthologous functional genes by sequence homology in trees of different a genus and/or species. DNA markers are e.g. for fibre coarseness, microfibril angle, pulpstrength and yield, lignin content, pitch propensity and calcium accumulation determinants.

    摘要翻译： 本发明涉及用于鉴定具有优异表型的单个树的方法，更具体地涉及可用于鉴定具有优异表型的单个树的分子标记和/或数量性状基因座（QTL）的方法。 分子标记和/或QTL包含限制性片段长度多态性模式或PCR-指纹。 分子标记和/或QTL可用于开发标记辅助育种，快速评估技术或通过不同种和/或物种的树中的序列同源性鉴定直向同源功能基因。 DNA标记是例如。 纤维粗糙度，微纤丝角度，纸浆强度和产量，木质素含量，沥青倾向和钙累积决定因素。

    Garbage collection in a computer system
    9.
    发明授权
    Garbage collection in a computer system 失效
    垃圾收集在计算机系统中

    公开(公告)号：US4755939A

    公开(公告)日：1988-07-05

    申请号：US934439

    申请日：1986-11-24

    申请人： Paul Watson

    发明人： Paul Watson

    IPC分类号： G06F12/02 ,  G06F11/00

    CPC分类号： G06F12/0261 ,  Y10S707/99957

    摘要： A computer system is described, having memory cells organized in a directed graph structure by means of pointers. Each cell has a reference count, and each pointer has a weight value. If a new pointer to a cell is created by copying an existing pointer, the new and existing pointers are given weights whose sum equals the old value of the existing pointer. In this way, the sum of the weights of the pointers to any cell are maintained equal to its reference count. If a pointer is destroyed, the reference count of the cell to which it points is reduced by the weight of the pointer. Thus, when the reference count of a cell reaches zero, it is safe to assume that there are no more existing pointers to it, and hence that cell my be reclaimed (garbage-collected) for re-use.

    摘要翻译： 描述了具有通过指针以有向图结构组织的存储器单元的计算机系统。 每个单元格都有一个引用计数，每个指针都有一个权重值。 如果通过复制现有指针创建一个新的单元指针，那么新的和现有的指针将赋予其等于现有指针的旧值的权重。 以这种方式，指向任何单元的指针的权重的总和保持等于其引用计数。 如果指针被破坏，则它指向的单元格的引用计数减少了指针的重量。 因此，当单元格的引用计数达到零时，可以安全地假设没有更多的现有指针，因此我的单元格被收回（垃圾回收）以供重用。

    Continuous Digestion of Chip Blends Containing a Western Red Cedar Chip Furnish
    10.
    发明申请
    Continuous Digestion of Chip Blends Containing a Western Red Cedar Chip Furnish 有权
    连续消化含有西式红松饼芯片的芯片混合物

    公开(公告)号：US20110186250A1

    公开(公告)日：2011-08-04

    申请号：US13009762

    申请日：2011-01-19

    申请人： Ranbir Heer ,  Paul Watson

    发明人： Ranbir Heer ,  Paul Watson

    IPC分类号： D21C3/24 ,  D21C3/00 ,  D21C9/10

    CPC分类号： D21C3/00 ,  D21C3/24 ,  D21C9/10

    摘要： A process is provided for delignifying lignocellulosic material, including feeding a lignocellulosic blend comprising a Western Red Cedar (WRC) chip furnish and a second lignocellulosic material into an aqueous alkaline pulping solution at the feed end of a digester to produce a lignocellulosic mass. The second lignocellulosic material is provided in a proportion that increases the density of the mass to enable the mass to move through the digester while minimizing production effects associated with low density WRC chips. The mass moves through the digester to produce a pulp that may be bleached.

    摘要翻译： 提供了木质纤维素材料脱木质素的方法，包括在消化器的进料端将包含西红杉（WRC）芯片配料和第二木质纤维素材料的木质纤维素混合物进料到碱性制浆水溶液中以产生木质纤维素块。 提供第二木质纤维素材料的比例，其增加了质量的密度，以使质量能够移动通过消化器，同时最小化与低密度WRC芯片相关的生产效应。 质量块通过蒸煮器移动以产生可能被漂白的纸浆。