摘要:
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.
摘要:
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.
摘要:
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.
摘要:
Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentiviruses, as well as novel tissue specific enhancer and promoter elements useful for optimizing liver specific transgene delivery. The transgene is preferably a blood clotting factor such as human factor IX (hFIX) or human factor VIII (hFVIII) and can be used for treatment of hemophilia.
摘要:
Articulated assemblies are all around us in nature as well as within the artificial environments and artificial systems we create. Computer based simulations are used to view, analyze, and modify motion specifications and sequences for articulated assemblies in the generation of avatars for multimedia and designing robotic/android systems. Articulated assembly specifications along with terrain and physical laws are employed in establishing an actuation and motion sequence for the assembly. However, other factors such as emotion, state of mind, etc. impact how the assembly actually moves and the physical aspect of the assembly. Embodiments of the invention allow for management of cyclic and acyclic elements to the overall motion through graphical user interfaces as well as the rapid establishment of new motion models through fractional combination of existing motion models as well as the association of a motion model to multiple articulated assemblies allowing simulations of herds, crowds etc.
摘要:
Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. Such an array is particularly well-suited for operation as a readout integrated circuit and in combination with a sensor array, forms a digital focal plane array.
摘要:
A digital focal plane array includes an all-digital readout integrated circuit in combination with a detector array. The readout circuit includes unit cell electronics, orthogonal transfer structures, and data handling structures. The unit cell electronics include an analog to digital converter. Orthogonal transfer structures enable the orthogonal transfer of data among the unit cells. Data handling structures may be configured to operate the digital focal plane array as a data encryptor/decipherer. Data encrypted and deciphered by the digital focal plane array need not be image data.
摘要:
Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. Such an array is particularly well-suited for operation as a readout integrated circuit and in combination with a sensor array, forms a digital focal plane array.
摘要:
Autonomously operating analog to digital converters are formed into a two dimensional array. The array may incorporate digital signal processing functionality. Such an array is particularly well-suited for operation as a readout integrated circuit and, in combination with a sensor array, forms a digital focal plane array.
摘要:
Systems, methods, and apparatuses for facilitating communication between remote services and applications installed on a device are described. In accordance with embodiments, each of a plurality of remote services generates an application-specific message intended for processing by a corresponding application installed on a device and transmits the application-specific message to a device management system (DMS) server, where it is queued. A DMS client installed on the device sends heartbeat messages to the DMS server indicating that the device is available to receive messages. In response to receiving the heartbeat messages, the DMS server transmits the application-specific messages to the DMS client. The DMS client then publishes each application-specific message to the particular application that the application-specific message was intended for.