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    Method for making a biodegradable adhesive for soft living tissue
    1.
    发明授权
    Method for making a biodegradable adhesive for soft living tissue 失效
    制造软生物体组织的生物降解性粘合剂的方法

    公开(公告)号：US4804691A

    公开(公告)日：1989-02-14

    申请号：US90861

    申请日：1987-08-28

    申请人： James P. English ,  Gerald W. McNeely ,  Richard L. Dunn

    发明人： James P. English ,  Gerald W. McNeely ,  Richard L. Dunn

    IPC分类号： A61L24/04 ,  C08G18/42 ,  C09J175/06 ,  C08G18/30

    CPC分类号： C09J175/06 ,  A61L24/046 ,  C08G18/4277 ,  C08G18/428 ,  C08G2230/00 ,  Y10S528/905

    摘要： A method for making an adhesive for use in joining soft living tissue including the steps of preparing a hydroxyl-terminated polyester by reacting a biodegradable monomer with a polyhydroxy polymerization initiator in the presence of an amount up to about 2.0 weight percent of a catalyst, and then preparing a diisocyanate-terminated prepolymer adhesive by reacting about 24 to 92 weight percent of the hydroxy-terminated polyester with about 8 to 76 weight percent excess aromatic diisocyante. The polyester and the diisocyanate are preferably dissolved in an organic solvent prior to the mixture thereof in a ratio of solids to solvent of about 60:40. The polyester is a polymer or copolymer of lactide, glycolide or .epsilon.-caprolactone. The initiator is ethylene glycol, diethylene glycol, pentaerythritol or 1,1,1-tris (hydroxymethyl) ethane. The catalyst is stannous octoate, a zinc compound, an aliphatic tertiary amine, dibutyltin diacetate or 1,4-diazabicyclo [2,2,2] octane.

    摘要翻译： 一种制造用于连接软性生物体组织的粘合剂的方法，其包括通过使可生物降解的单体与多羟基聚合引发剂在至多约2.0重量％的催化剂的量存在下反应制备羟基封​​端的聚酯的步骤，以及 然后通过使约24至92重量％的羟基封端的聚酯与约8至7​​6重量％的过量芳族二异氰酸酯反应制备二异氰酸酯封端的预聚物粘合剂。 聚酯和二异氰酸酯优选在固体与溶剂的比例为约60:40的混合物之前溶解在有机溶剂中。 聚酯是丙交酯，乙交酯或ε-己内酯的聚合物或共聚物。 引发剂是乙二醇，二甘醇，季戊四醇或1,1,1-三（羟甲基）乙烷。 催化剂为辛酸亚锡，锌化合物，脂族叔胺，二乙酸二丁基锡或1,4-二氮杂双环[2,2,2]辛烷。

    Biodegradable polymer composition
    2.
    发明授权
    Biodegradable polymer composition 有权

    公开(公告)号：US06528080B2

    公开(公告)日：2003-03-04

    申请号：US10047483

    申请日：2002-01-14

    申请人： Richard L Dunn ,  James P. English

    发明人： Richard L Dunn ,  James P. English

    IPC分类号： A61F200

    CPC分类号： A61K9/0024

    摘要： A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

    Biogradable in-situ forming implants and methods of producing the same
    3.
    再颁专利
    Biogradable in-situ forming implants and methods of producing the same 有权
    可生物降解的原位成形植入物及其制备方法

    公开(公告)号：USRE37950E1

    公开(公告)日：2002-12-31

    申请号：US09536579

    申请日：2000-03-28

    申请人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David P. Vanderbilt

    发明人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David P. Vanderbilt

    IPC分类号： A61K908

    CPC分类号： A61K9/0024 ,  A61F2002/30062 ,  A61F2002/30583 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61L15/44 ,  A61L15/62 ,  A61L24/0042 ,  A61L24/046 ,  A61L26/009 ,  A61L27/18 ,  A61L27/50 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/406 ,  C08L75/04 ,  C08L67/04

    摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

    摘要翻译： 提供可生物降解的聚合物用于为动物提供可注射的，原位成型的固体可生物降解植入物。 将聚合物以液体形式置于动物体内并固化以原位形成植入物。 形成所述植入物的热塑性体系包括以下步骤：将非反应性聚合物溶解在生物相容性溶剂中以形成液体，将液体置于动物体内，并允许溶剂消散以产生植入物。 一种替代的热固性体系包括将有效量的液体丙烯酸酯封端的，可生物降解的预聚物和固化剂混合在一起，将液体混合物置于动物体内并使预聚物固化以形成植入物。 两种系统通过在注射到体内之前向液体中添加有效水平的生物活性剂来提供可注射的，可固体的可生物降解的递送系统。