公开(公告)号：US08226598B2

公开(公告)日：2012-07-24

申请号：US10634656

申请日：2003-08-05

申请人： Richard L. Dunn ,  Cody L. Yarborough

发明人： Richard L. Dunn ,  Cody L. Yarborough

IPC分类号： A61M37/00

CPC分类号： A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2089 ,  A61M5/3202 ,  A61M2039/042 ,  B01F5/0685

摘要： The present invention relates generally to medical devices for mixing, preparing and administering therapeutic compositions, and more particularly to a system comprising two syringes and a locking ring wherein two compositions are mixed between the two syringes immediately prior to administration.

摘要翻译： 本发明一般涉及用于混合，制备和施用治疗组合物的医疗装置，更具体地涉及包括两个注射器和锁定环的系统，其中两个组合物在施用前立即在两个注射器之间混合。

公开(公告)号：US20110027389A1

公开(公告)日：2011-02-03

申请号：US12812670

申请日：2009-01-13

申请人： Richard L. Dunn

发明人： Richard L. Dunn

IPC分类号： A61K33/24 ,  A61K31/485 ,  A61K31/65 ,  A61K31/445 ,  A61K38/09 ,  A61P35/00 ,  A61P31/00 ,  A61P29/00 ,  A61P25/18 ,  A61M5/00 ,  A61M25/00

CPC分类号： A61L29/06 ,  A61K9/0024 ,  A61K31/445 ,  A61K31/485 ,  A61K31/65 ,  A61K33/24 ,  A61L27/18 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L29/085 ,  A61L29/14 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/416 ,  A61L2300/43 ,  A61L2300/604 ,  A61L2400/06 ,  C08L67/04

摘要： Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.

摘要翻译： 提供了液体可生物降解聚合物和生物相容性溶剂的低粘度可生物降解聚合物溶液和使用该组合物形成可生物降解的液体聚合物植入物的方法。

公开(公告)号：US20100234305A1

公开(公告)日：2010-09-16

申请号：US12784343

申请日：2010-05-20

申请人： Richard L. Dunn ,  John Steven Garrett ,  Harish Ravivarapu ,  Bhagya L. Chandrashekar

发明人： Richard L. Dunn ,  John Steven Garrett ,  Harish Ravivarapu ,  Bhagya L. Chandrashekar

IPC分类号： A61K38/08 ,  A61P5/24

CPC分类号： A61K38/09 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/19 ,  A61K47/22 ,  A61K47/34 ,  B65D81/3205

摘要： The present invention is directed to a flowable composition that is suitable for use as a controlled release implant. The flowable composition includes a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid. The flowable composition also includes a biocompatible polar aprotic solvent. The biocompatible polar aprotic solvent is miscible to dispersible in aqueous medium or body fluid. The flowable composition also includes leuprolide acetate.

公开(公告)号：US07128927B1

公开(公告)日：2006-10-31

申请号：US09060047

申请日：1998-04-14

申请人： Richard L. Dunn

发明人： Richard L. Dunn

IPC分类号： A61K9/107 ,  A61K47/32 ,  A61K47/34

CPC分类号： A61K9/0024 ,  Y02A50/465

摘要： The invention is provides a composition for sustained delivery of a biologically active agent comprising a biologically active mixture and a controlled release formulation. The composition protects the biologically active agent from being destroyed by the controlled release composition. The biologically active mixture includes the biologically active agent and a pharmaceutically acceptable protective carrier. The controlled release formulation includes a pharmaceutically acceptable, biodegradable, matrix forming material that is substantially insoluble in aqueous or body fluids and a pharmaceutically acceptable organic solvent. The biologically active mixture is combined with the controlled release formulation to form an emulsion, the delivery composition, which is then administered to a patient. The protective carrier can be an aqueous substance, a non-aqueous substance or a combination of both. The matrix forming material can be a polymeric material, a non-polymeric material or a combination of both. The organic solvent can have a solubility ranging from a high water solubility to a low water solubility.

摘要翻译： 本发明提供了用于持续递送包含生物活性混合物和控释制剂的生物活性剂的组合物。 组合物保护生物活性剂免受控释组合物的破坏。 生物活性混合物包括生物活性剂和药学上可接受的保护载体。 控制释放制剂包括药学上可接受的，可生物降解的基质形成材料，其基本上不溶于水性或体液和药学上可接受的有机溶剂。 将生物活性混合物与控制释放制剂组合以形成乳剂，然后将其输送给患者。 保护载体可以是水性物质，非水性物质或两者的组合。 基体形成材料可以是聚合材料，非聚合材料或两者的组合。 有机溶剂可以具有从高水溶性到低水溶性的溶解度。

公开(公告)号：US06461631B1

公开(公告)日：2002-10-08

申请号：US09442203

申请日：1999-11-16

申请人： Richard L Dunn ,  James P. English

发明人： Richard L Dunn ,  James P. English

IPC分类号： A61F202

CPC分类号： A61K9/0024

摘要： A flowable composition containing a biocompatible, biodegradable, branched thermoplastic polymer is used to form solid matrices such as implants and controlled-release, drug-compositions in a body. The flowable composition with or without bioactive agent can be administered by syringe and needle to form in situ a solid matrix. Alternatively, the flowable composition can be used to form ex vivo solid biodegradable matrices such as articles, implants and devices. The articles implants and the like can then used as solid fasteners, prosthetic devices, and controlled drug compositions.

公开(公告)号：US5888533A

公开(公告)日：1999-03-30

申请号：US975765

申请日：1997-11-21

申请人： Richard L. Dunn

发明人： Richard L. Dunn

IPC分类号： A61F2/28 ,  A61K9/00 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22 ,  A61K47/34 ,  A61F2/02

CPC分类号： A61K9/0024 ,  A61K47/34 ,  A61K47/14 ,  A61K47/20 ,  A61K47/22

摘要： The invention relates to a method and composition for forming an implant in-situ within a body using non-polymeric materials, and the use of such implants as medical devices and drug delivery systems. The composition can be applied to an animal to treat periodontal disease or other tissue defect, enhance compatibility and performance of an implantable article, and deliver a biologically active agent.

公开(公告)号：US5780044A

公开(公告)日：1998-07-14

申请号：US761015

申请日：1996-12-05

申请人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

发明人： Gerald L. Yewey ,  Nancy L. Krinick ,  Richard L. Dunn ,  Michael L. Radomsky ,  Gerbrand Brouwer ,  Arthur J. Tipton

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K9/20 ,  A61K9/22 ,  A61K9/70 ,  A61K47/48 ,  A61K49/00 ,  A61L15/44 ,  A61F2/00 ,  A61K9/127 ,  A61K9/52

CPC分类号： A61K9/0024 ,  A61K31/4439 ,  A61K31/485 ,  A61K31/704 ,  A61K38/09 ,  A61K38/27 ,  A61K47/34 ,  A61K47/48176 ,  A61K47/48192 ,  A61K47/482 ,  A61K47/48784 ,  A61K47/48853 ,  A61K49/0017 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0063 ,  A61K49/0091 ,  A61K9/10 ,  A61K9/146 ,  A61K9/5026 ,  A61K9/5047 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/0085 ,  A61L27/18 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L31/16 ,  A61K47/42 ,  A61L2300/604 ,  A61L2300/62 ,  A61L2400/06 ,  Y10S514/90 ,  Y10S525/937 ,  Y10S977/774 ,  Y10S977/783 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/915 ,  Y10S977/918

摘要： Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

摘要翻译： 提供改进的生物相容性液体递送组合物，其可用于形成活性剂的缓释递送系统。 组合物包括与受控释放组分组合的生物相容性聚合物或预聚物的液体制剂。 受控释放组分包括活性剂。 这些组合物可以以液体形式引入受试者的身体，其然后在现场固化或固化以形成控释植入物或膜敷料。 液体递送组合物也可以非原位地用于产生控释植入物。 还提供了形成受控释放植入物并使用液体制剂治疗受试者的方法。

公开(公告)号：US5707647A

公开(公告)日：1998-01-13

申请号：US749029

申请日：1996-11-14

申请人： Richard L. Dunn ,  Gerald L. Yewey ,  Jeffrey L. Southard ,  John E. Urheim

发明人： Richard L. Dunn ,  Gerald L. Yewey ,  Jeffrey L. Southard ,  John E. Urheim

IPC分类号： A61L17/00 ,  A61K9/00 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L17/06 ,  A61L24/00 ,  A61L26/00 ,  A61L27/00 ,  A61L27/54 ,  A61L27/58 ,  A61L29/00 ,  A61L29/14 ,  A61L29/16 ,  A61L31/14 ,  A61L31/16 ,  A61L15/22

CPC分类号： A61K9/0024 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L17/06 ,  A61L24/0042 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/009 ,  A61L27/54 ,  A61L27/58 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/62 ,  Y10S528/905 ,  Y10S602/904

摘要： A medical device which is a surgically implantable device coated with an adjunctive polymer system. The adjunctive polymer system forms a solid matrix when introduced into a human or animal body. The adjunctive polymer system can contain a drug or a medicament which is released over time from the solid matrix. The adjunctive polymer system contacts body tissue into which the surgically implantable device is implanted.

公开(公告)号：US5702716A

公开(公告)日：1997-12-30

申请号：US70498

申请日：1993-06-02

申请人： Richard L. Dunn ,  Arthur J. Tipton

发明人： Richard L. Dunn ,  Arthur J. Tipton

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K47/34 ,  A61L15/44 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L26/00 ,  A61K9/20

CPC分类号： A61K9/0024 ,  A61K47/34 ,  A61L15/44 ,  A61L24/0015 ,  A61L24/0026 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L26/0019 ,  A61L26/0076 ,  A61L26/009 ,  A61L2300/602

摘要： The invention is directed to an improved system for controlled release of biologically active materials and to a liquid composition for its formation. The liquid composition is composed of a thermoplastic polymer, rate modifying agent, bioactive material and organic solvent. The liquid composition is capable of forming a biodegradable and/or bioerodible microporous, solid polymer matrix. The matrix is useful as an implant in patients (humans and animals) for delivery of biologically active substances to tissues or organs.

摘要翻译： 本发明涉及用于控制释放生物活性物质和用于其形成的液体组合物的改进系统。 液体组合物由热塑性聚合物，速率改性剂，生物活性材料和有机溶剂组成。 液体组合物能够形成可生物降解和/或生物腐蚀性微孔固体聚合物基质。 该基质可用作患者（人和动物）中用于将生物活性物质递送至组织或器官的植入物。

公开(公告)号：US5278202A

公开(公告)日：1994-01-11

申请号：US788159

申请日：1991-12-23

申请人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David D. Vanderbilt

发明人： Richard L. Dunn ,  James P. English ,  Donald R. Cowsar ,  David D. Vanderbilt

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61K9/00 ,  A61K9/22 ,  A61K47/34 ,  A61L15/44 ,  A61L15/62 ,  A61L24/00 ,  A61L24/04 ,  A61L24/06 ,  A61L26/00 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  C08L67/00 ,  C08L69/00 ,  C08L77/00

CPC分类号： A61K9/0024 ,  A61K47/34 ,  A61L15/44 ,  A61L15/62 ,  A61L24/0015 ,  A61L24/0026 ,  A61L24/0042 ,  A61L24/046 ,  A61L24/06 ,  A61L26/0019 ,  A61L26/0066 ,  A61L26/0076 ,  A61L26/009 ,  A61L27/16 ,  A61L27/18 ,  A61L27/26 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61F2002/30062 ,  A61F2002/30583 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/604 ,  Y10S525/937

摘要： A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.