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5 条记录 (耗时 0.017 秒)

    Method for purifying FSH
    1.
    发明授权
    Method for purifying FSH 失效

    公开(公告)号：US06414123B1

    公开(公告)日：2002-07-02

    申请号：US09442132

    申请日：1999-11-16

    申请人： James R. Musick ,  Erik Van Horn

    发明人： James R. Musick ,  Erik Van Horn

    IPC分类号： C07K318

    CPC分类号： C07K14/59

    摘要： The present invention provides a method for purifying follicle stimulating hormone (FSH) from biological samples, for example, from human pituitary glands or human postmenopausal urine, wherein the FSH is contaminated with other proteins, by use of dye-ligand affinity chromatography (DAC). Depending on the starting material used and the initial purity of FSH in the starting material, additional purification steps may be employed. These steps preferably involve the use of hydrophobic interaction chromatography. This process may be used to generate affinity pure FSH suitable for therapeutic applications. The methods of the invention provide high purity FSH with high overall yield. A further advantage is the ability to easily regenerate the chromatography media for re-use, thus providing added economy to the purification process.

    Method for purifying FSH
    2.
    发明授权
    Method for purifying FSH 失效
    FSH净化方法

    公开(公告)号：US5990288A

    公开(公告)日：1999-11-23

    申请号：US75423

    申请日：1998-05-08

    申请人： James R. Musick ,  Erik Van Horn

    发明人： James R. Musick ,  Erik Van Horn

    IPC分类号： C07K14/59 ,  C07K3/18 ,  C07K3/20 ,  C07K3/28

    CPC分类号： C07K14/59

    摘要： The present invention provides a method for purifying follicle stimulating hormone (FSH) from biological samples, for example, from human pituitary glands or human postmenopausal urine, wherein the FSH is contaminated with other proteins, by use of dye-ligand affinity chromatography (DAC). This process may be used to generate affinity pure FSH suitable for therapeutic applications.

    摘要翻译： 本发明提供了通过使用染料 - 配体亲和层析（DAC）从生物样品例如来自人垂体腺或人类绝经后尿中纯化促卵泡激素（FSH）的方法，其中FSH被其他蛋白质污染， 。 该方法可用于产生适用于治疗应用的亲和纯FSH。

    STEM CELL LINE FOR TREATMENT OF VARIOUS MEDICAL CONDITIONS
    3.
    发明申请
    STEM CELL LINE FOR TREATMENT OF VARIOUS MEDICAL CONDITIONS 审中-公开

    公开(公告)号：US20190153386A1

    公开(公告)日：2019-05-23

    申请号：US15816982

    申请日：2017-11-17

    申请人： James R. Musick ,  Tiana Tonrey ,  Richard Dean

    发明人： James R. Musick ,  Tiana Tonrey ,  Richard Dean

    IPC分类号： C12N5/0797 ,  C12N5/0793 ,  C12N5/077 ,  C12N5/071 ,  A61K35/12

    摘要： An isolated biological stem cell or a set of biological stem cells that include human mesenchymal stem cell line 120816CT, deposited under ATCC Accession number PTA-124321, and differentiated into at least one type of cell selected from the group: neural stem cells, nephron progenitor cells, cardiomyocytes, neurons, glial cells, and vascular endothelial cells. The neurons comprise cholinergic neurons or dopaminergic neurons. A method of treating at least one human physical condition is also disclosed. The method includes injecting a patient with stem cell line 120816 CT to treat osteoarthritis, tendonitis, herniated disc, ligament damage, acute and chronic kidney disease and injury, Parkinson's disease, traumatic brain injury, Alzheimer's disease, amyotrophic lateral sclerosis, spinal cord injury, other skeletal muscular disorders, Lupus erythematosus, multiple sclerosis, cardiovascular disease, Graft-versus host disease, liver dysfunction or diseases, Type 1 and Type 2 diabetes, myocardial ischemia, heart failure, coronary artery disease, and other disorders characterized by inflammation.