Reovirus for the treatment of cellular proliferative disorders
    3.
    发明授权
    Reovirus for the treatment of cellular proliferative disorders 有权
    用于治疗细胞增殖性疾病的呼肠孤病毒

    公开(公告)号:US08066985B2

    公开(公告)日:2011-11-29

    申请号:US12323223

    申请日:2008-11-25

    IPC分类号: A61K49/00 A61K39/15

    摘要: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒,则可以使用血清型1(例如,菌株Lang),血清型2(例如菌株琼斯),血清型3(例如,菌株Dearing或菌株Abney)以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合,以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    Reovirus for the treatment of neoplasia
    4.
    发明授权
    Reovirus for the treatment of neoplasia 有权
    呼肠孤病毒治疗瘤形成

    公开(公告)号:US06576234B2

    公开(公告)日:2003-06-10

    申请号:US09852017

    申请日:2001-05-10

    IPC分类号: A01N6300

    摘要: Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, and use of reovirus for manufacture of a medicament for the treatment of neoplasia, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other sterotypes or strains of reovirus can be used. Combinations of more than one type and/or strain or reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的肿瘤施用呼肠孤病毒和使用呼肠孤病毒来制造用于治疗肿瘤的药物的方法。 呼肠病毒的施用使其最终直接接触肿瘤细胞。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒,可以使用1型(例如,菌株Lang),2型(例如菌株琼斯),3型(例如,菌株Dearing或菌株Abney)以及其它定向型或呼肠孤病毒菌株。 可以使用多于一种类型和/或菌株或呼肠孤病毒的组合,以及来自不同动物种的呼肠病毒。 可以治疗实体肿瘤或造血赘生物。

    Reovirus for the Treatment of Cellular Proliferative Disorders
    5.
    发明申请
    Reovirus for the Treatment of Cellular Proliferative Disorders 有权
    呼肠孤病毒治疗细胞增生性疾病

    公开(公告)号:US20110014155A1

    公开(公告)日:2011-01-20

    申请号:US12841550

    申请日:2010-07-22

    摘要: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒,则可以使用血清型1(例如,菌株Lang),血清型2(例如菌株琼斯),血清型3(例如,菌株Dearing或菌株Abney)以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合,以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    Reovirus for the treatment of cellular proliferative disorders
    6.
    发明授权
    Reovirus for the treatment of cellular proliferative disorders 有权
    用于治疗细胞增殖性疾病的呼肠孤病毒

    公开(公告)号:US06455038B1

    公开(公告)日:2002-09-24

    申请号:US09594343

    申请日:2000-06-15

    IPC分类号: A61K3576

    摘要: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒,则可以使用血清型1(例如,菌株Lang),血清型2(例如菌株琼斯),血清型3(例如,菌株Dearing或菌株Abney)以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合,以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    Reovirus for the treatment of cellular proliferative disorders

    公开(公告)号:US08071087B2

    公开(公告)日:2011-12-06

    申请号:US12841550

    申请日:2010-07-22

    IPC分类号: A61K39/15 A61K48/00

    摘要: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    Reovirus for the Treatment of Cellular Proliferative Disorders
    8.
    发明申请
    Reovirus for the Treatment of Cellular Proliferative Disorders 有权
    呼肠孤病毒治疗细胞增生性疾病

    公开(公告)号:US20090117082A1

    公开(公告)日:2009-05-07

    申请号:US12323223

    申请日:2008-11-25

    IPC分类号: A61K35/76

    摘要: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的增殖性病症施用呼肠孤病毒来治疗增殖性疾病的方法。 施用呼肠孤病毒使其最终直接接触ras介导的增殖细胞。 增生性疾病包括但不限于赘生物。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠孤病毒是人呼肠病毒,则可以使用血清型1(例如,菌株Lang),血清型2(例如菌株琼斯),血清型3(例如,菌株Dearing或菌株Abney)以及呼肠孤病毒的其它血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合,以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。

    REOVIRUS FOR THE TREATMENT OF NEOPLASIA
    9.
    发明申请

    公开(公告)号:US20090110665A1

    公开(公告)日:2009-04-30

    申请号:US12264072

    申请日:2008-11-03

    IPC分类号: A61K35/76

    摘要: Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    REOVIRUS FOR THE TREATMENT OF NEOPLASIA
    10.
    发明申请
    REOVIRUS FOR THE TREATMENT OF NEOPLASIA 审中-公开
    REOVIRUS治疗NEOPLASIA

    公开(公告)号:US20090098089A1

    公开(公告)日:2009-04-16

    申请号:US12252953

    申请日:2008-10-16

    IPC分类号: A61K35/12 A61P35/00

    摘要: Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.

    摘要翻译: 公开了通过向Ras介导的肿瘤施用呼肠孤病毒来治疗瘤形成的方法。 呼肠病毒的施用使其最终直接接触肿瘤细胞。 可以使用人呼肠病毒,非人哺乳动物呼肠病毒和/或禽呼肠孤病毒。 如果呼肠病毒是人呼肠病毒,可以使用类型1(例如,菌株Lang),2型(例如菌株琼斯),3型(例如,菌株Dearing或菌株Abney)以及其它呼肠孤病毒血清型或菌株。 可以使用多于一种类型和/或菌株的呼肠病病毒的组合,以及来自不同动物种类的呼肠弧病毒。 可以治疗实体肿瘤或造血赘生物。