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    THERMOPLASTIC FLUOROPOLYMER-COATED MEDICAL DEVICES
    1.
    发明申请
    THERMOPLASTIC FLUOROPOLYMER-COATED MEDICAL DEVICES 有权
    热塑性氟聚合物涂层医疗器械

    公开(公告)号：US20120065721A1

    公开(公告)日：2012-03-15

    申请号：US13282892

    申请日：2011-10-27

    申请人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    发明人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L27/34 ,  C08L101/04

    摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.

    摘要翻译： 一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。 含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。 这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。 此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。 该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。

    Thermoplastic fluoropolymer-coated medical devices
    2.
    发明授权
    Thermoplastic fluoropolymer-coated medical devices 有权
    热塑性含氟聚合物涂层医疗器械

    公开(公告)号：US08048440B2

    公开(公告)日：2011-11-01

    申请号：US11378401

    申请日：2006-03-16

    申请人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    发明人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    IPC分类号： A61F2/82

    CPC分类号： A61L31/10 ,  A61L27/34 ,  C08L101/04

    摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used. The desirable mechanical characteristics are surprising given the absence of cross-linking monomers and curing agents that would otherwise render such materials inadequately biocompatible. The perfluoroalkylvinylether may be perfluoromethylvinylether, perfluoroethylvinylether or perfluoropropylvinylether.

    摘要翻译： 一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。 含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。 这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。 此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。 该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。 鉴于不存在交联单体和固化剂，否则将使得这些材料生物相容性不足，理想的机械特性令人惊奇。 全氟烷基乙烯基醚可以是全氟甲基乙烯基醚，全氟乙基乙烯基醚或全氟丙基乙烯基醚。

    Thermoplastic fluoropolymer-coated medical devices
    3.
    发明授权
    Thermoplastic fluoropolymer-coated medical devices 有权
    热塑性含氟聚合物涂层医疗器械

    公开(公告)号：US08609125B2

    公开(公告)日：2013-12-17

    申请号：US13282892

    申请日：2011-10-27

    申请人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    发明人： James W. Chang ,  Robert L. Cleek ,  Edward H. Cully ,  Michael J. Vonesh

    IPC分类号： A61F2/02

    CPC分类号： A61L31/10 ,  A61L27/34 ,  C08L101/04

    摘要： A medical device provided with at least a partial surface coating of a thermoplastic copolymer of tetrafluoroethylene and perfluoroalkylvinylether that is free of cross-linking monomers and curing agents. The fluoropolymer coating is preferably an amorphous thermoplastic, is highly inert and biocompatible, has elastomeric characteristics that provide desirable mechanical properties such as good flexibility and durability. These characteristics allow the coating to be considered “functionally transparent” because it withstands mechanical deformations required for the assembly, deployment, expansion, and placement of medical devices, without any adverse effect on the mechanical and biological functionality of the coated device. Further, its inertness, derived from the perfluorocarbon structure, contributes to its functionally transparent nature. The coating can be provided with various liquid or solid additives, can be loaded with large quantities of additives including a wide range of therapeutic agents, and has excellent drug elution characteristics when elutable additives are used.

    摘要翻译： 一种医疗装置，其具有不含交联单体和固化剂的四氟乙烯和全氟烷基乙烯基醚的热塑性共聚物的至少部分表面涂层。 含氟聚合物涂层优选为无定形热塑性塑料，具有高度惰性和生物相容性，具有提供所需机械性能（例如良好的柔韧性和耐久性）的弹性体特性。 这些特性使得涂层被认为是“功能上透明的”，因为它可以承受医疗装置的组装，展开，膨胀和放置所需的机械变形，而不会对涂覆装置的机械和生物功能产生任何不利影响。 此外，其衍生自全氟化碳结构的惰性有助于其功能上的透明性。 该涂层可以提供各种液体或固体添加剂，可以加载大量的添加剂，包括广泛的治疗剂，并且当使用可洗脱添加剂时具有优异的药物洗脱特性。