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14 条记录 (耗时 0.032 秒)

    Methods and compositions for sealing tissue leaks
    2.
    发明申请
    Methods and compositions for sealing tissue leaks 审中-公开
    密封组织渗漏的方法和组合物

    公开(公告)号：US20050037960A1

    公开(公告)日：2005-02-17

    申请号：US10675460

    申请日：2003-09-30

    申请人： James Rolke ,  Luis Burzio

    发明人： James Rolke ,  Luis Burzio

    IPC分类号： A61L24/00 ,  A61L24/04 ,  A61L24/10 ,  A61K38/39

    CPC分类号： A61L24/108 ,  A61L24/001 ,  A61L24/043 ,  A61L24/10 ,  C08L89/00

    摘要： The invention provides methods and compositions that are useful for adhering biological and/or synthetic tissues, sealing fluid and/or gaseous leaks in biological and/or synthetic tissues, and preparing implants useful for delivery of a bioactive molecule such as a drug, for bulking applications, or for tissue prostheses. The present invention also relates to bio-erodable adhesive or occluding compositions and methods of using the same.

    摘要翻译： 本发明提供了可用于粘附生物和/或合成组织，密封生物和/或合成组织中的流体和/或气体泄漏的方法和组合物，以及制备用于递送生物活性分子例如药物的用于膨胀的植入物 应用或组织假体。 本发明还涉及生物可侵蚀粘合剂或闭塞组合物及其使用方法。

    Markers for pre-cancer and cancer calls and the method to interfere with cell proliferation therein
    3.
    发明申请
    Markers for pre-cancer and cancer calls and the method to interfere with cell proliferation therein 有权
    肿瘤前期癌症和癌症呼吸的标志物以及干扰细胞增殖的方法

    公开(公告)号：US20060241033A1

    公开(公告)日：2006-10-26

    申请号：US10557458

    申请日：2004-05-21

    申请人： Luis Burzio ,  Jaime Villegas ,  Veronica Burzio

    发明人： Luis Burzio ,  Jaime Villegas ,  Veronica Burzio

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

    CPC分类号： C12Q1/6886 ,  C07F9/65616 ,  C12N5/0693 ,  C12N15/11 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/53 ,  C12N2330/10 ,  C12N2501/06 ,  C12Q1/6804 ,  C12Q1/701 ,  C12Q1/708 ,  C12Q2600/112 ,  C12Q2600/158

    摘要： A novel family of human mitochondrial RNAs, referrred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therrefore, a novel approach for cancer therapy.

    摘要翻译： 描述了在正常，癌前和癌细胞中差异表达的人类线粒体RNA的新家族，被称为嵌合RNA。 提供靶向嵌合RNA的寡核苷酸。 所描述的寡核苷酸或其类似物可用于癌症诊断和癌症治疗以及研究。 在本发明的一个实施方案中，这些寡核苷酸与有义或与反义线粒体嵌合RNA杂交，并且杂交结果可用于区分正常增殖细胞，癌前细胞和癌细胞。 在本发明的另一个实施方案中，组合物包含与导致癌细胞和癌前细胞死亡的人嵌合RNA杂交的寡核苷酸，而在正常细胞中没有作用，从而构成癌症治疗的新方法。

    Non-destructive quality control method for microarray substrate coatings via labeled doping
    5.
    发明申请
    Non-destructive quality control method for microarray substrate coatings via labeled doping 审中-公开
    通过标记掺杂的微阵列基底涂层的非破坏性质量控制方法

    公开(公告)号：US20060003376A1

    公开(公告)日：2006-01-05

    申请号：US11213984

    申请日：2005-08-30

    申请人： Samuel Conzone ,  Luis Burzio ,  Dan Haines

    发明人： Samuel Conzone ,  Luis Burzio ,  Dan Haines

    IPC分类号： C12Q1/68 ,  C12M1/34 ,  C03C3/089

    CPC分类号： B82Y30/00 ,  C03C17/30 ,  C03C17/3405 ,  C03C2218/355 ,  G01N33/54393 ,  Y10T428/31612 ,  Y10T428/31663

    摘要： A non-destructive method of determining the uniformity of a coating on a substrate comprises coating the substrate with a homogenous coating mixture comprising a labeled compound and a chemically functional compound to which other chemical moieties can be bound, and detecting the presence and locations of the labeled compound on the surface. The invention also relates to a surface for attachment of molecules comprising a substrate and a coating thereon of a homogeneous mixture of a labeled compound and a first chemically functional compound to which other chemical moieties can be bound.

    摘要翻译： 确定基材上涂层的均匀性的非破坏性方法包括用包含标记化合物和化学官能化合物的均匀涂层混合物涂覆底物，其中可结合其它化学部分的化合物，并且检测其中的存在和位置 表面上标有化合物。 本发明还涉及用于附着包含底物和其上涂层的分子的标记化合物和第一化学官能化合物的均匀混合物的表面，其它化学部分可以结合到其上。

    Protein and nucleic acid sequence encoding a KRILL-derived cold adapted trypsin-like activity enzyme
    7.
    发明授权
    Protein and nucleic acid sequence encoding a KRILL-derived cold adapted trypsin-like activity enzyme 有权
    编码KRILL衍生的冷适应胰蛋白酶样活性酶的蛋白质和核酸序列

    公开(公告)号：US07202074B2

    公开(公告)日：2007-04-10

    申请号：US10896010

    申请日：2004-07-22

    申请人： Juan A. Asenjo ,  Barbara A. Andrews ,  Fernando Reyes ,  Mauricio Salamanca ,  Luis Burzio

    发明人： Juan A. Asenjo ,  Barbara A. Andrews ,  Fernando Reyes ,  Mauricio Salamanca ,  Luis Burzio

    IPC分类号： C12N9/64 ,  C12N15/57 ,  C12N15/70 ,  C12N15/79 ,  C11D3/386

    CPC分类号： C12N9/6408

    摘要： The present invention provides nucleic acid and corresponding amino acid sequences of two isoforms of cold adapted trypsin-like activity protein, insolated from antarctic marine origin, preferably from antarctic krill (Euphausia superba) that can be used in a variety of industrial contexts and commercial purposes including laundry detergents, food processing, drugs and skin care products. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the cold adapted trypsin-like protein.

    摘要翻译： 本发明提供了可以用于各种工业环境和商业目的的来自南极海洋来源的，优选来自南极磷虾（Euphausia superba）的冷适应的胰蛋白酶样活性蛋白质的两种同种型的核酸和相应的氨基酸序列 包括洗衣粉，食品加工，药品和护肤品。 本发明还涉及包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生和使用冷适应的胰蛋白酶样蛋白质的方法。