公开(公告)号：US20230144627A1

公开(公告)日：2023-05-11

申请号：US17967443

申请日：2022-10-17

Applicant: Janssen Biotech, Inc.

Inventor： Gilles Bignan ,  Peter Connolly ,  James Patrick Edwards ,  Stuart Emanuel ,  Sylvie Laquerre ,  Tianbao Lu ,  Mark Richter ,  Leonid Beigelman ,  Santhosh Kumar Thatikonda ,  Guangyi Wang ,  Minghong Zhong

IPC: C07H21/02 ,  A61K9/00 ,  A61P31/20 ,  A61P35/00 ,  A61K9/10 ,  A61P31/12 ,  A61K31/7076

CPC classification number: C07H21/02 ,  A61K9/0095 ,  A61P31/20 ,  A61P35/00 ,  A61K9/10 ,  A61P31/12 ,  A61K31/7076

Abstract: Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:




wherein R1A, R1B, R1C, B1, R2A, and R2B are defined herein.

公开(公告)号：US11472830B2

公开(公告)日：2022-10-18

申请号：US15820592

申请日：2017-11-22

Applicant: Janssen Biotech, Inc.

Inventor： Gilles Bignan ,  Peter Connolly ,  James Patrick Edwards ,  Stuart Emanuel ,  Sylvie Laquerre ,  Tianbao Lu ,  Mark Richter ,  Leonid Beigelman ,  Santhosh Kumar Thatikonda ,  Guangyi Wang ,  Minghong Zhong

IPC: C07H21/02 ,  A61P31/12 ,  A61K31/7084 ,  A61K9/00 ,  A61P31/20 ,  A61P35/00 ,  A61K9/10 ,  A61K31/7076

Abstract: Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1c, B1, R2A, and R2B are defined herein.

公开(公告)号：US20210277046A1

公开(公告)日：2021-09-09

申请号：US17260886

申请日：2019-07-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James P. Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Gilles Bignan ,  Wim Bert Griet Schepens ,  Marcel Viellevoye ,  Johannes Wilhelmus J.F. Thuring

IPC: C07H19/207 ,  A61P35/00 ,  C07H19/23

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.

公开(公告)号：US11597746B2

公开(公告)日：2023-03-07

申请号：US17260886

申请日：2019-07-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James P. Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Gilles Bignan ,  Wim Bert Griet Schepens ,  Marcel Viellevoye ,  Johannes Wilhelmus J. F. Thuring

IPC: C07H19/207 ,  C07H19/23 ,  A61P35/00

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I), wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.

公开(公告)号：US11492367B2

公开(公告)日：2022-11-08

申请号：US16478866

申请日：2018-01-26

Applicant: Janssen Biotech, Inc.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James Patrick Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Minghong Zhong ,  Gilles Bignan ,  Wim Schepens ,  Marcel Viellevoye ,  Johannes Wilhelmus John Fitzgerald Thuring

IPC: C07H21/02 ,  A61K48/00 ,  C07H21/00 ,  A61P31/12 ,  A61P35/00

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.

公开(公告)号：US20230287034A1

公开(公告)日：2023-09-14

申请号：US18177864

申请日：2023-03-03

Applicant: JANSSEN BIOTECH, INC.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James P. Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Gilles Bignan ,  Wim Bert Griet Schepens ,  Marcel Viellevoye ,  Johannes Wilhelmus J.F. Thuring

IPC: C07H19/207 ,  A61P35/00 ,  C07H19/23

CPC classification number: C07H19/207 ,  A61P35/00 ,  C07H19/23

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:




wherein R1, R1′, X1, B1, R2, R2′, B2, X2, R3, Z-M-Y, and Y1-M1-Z1 are as defined herein.

公开(公告)号：US20230146410A1

公开(公告)日：2023-05-11

申请号：US17982218

申请日：2022-11-07

Applicant: Janssen Biotech, Inc.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James Patrick Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Minghong Zhong ,  Gilles Bignan ,  Wim Schepens ,  Marcel Viellevoye ,  Johannes Wilhelmus John Fitzgerald Thuring

IPC: C07H21/00 ,  A61P31/12 ,  A61P35/00

CPC classification number: C07H21/00 ,  A61P31/12 ,  A61P35/00

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows:




wherein R, R1B, R1C, R2B, R2C, B1, W, X, Y, Z are defined herein.

公开(公告)号：US11021511B2

公开(公告)日：2021-06-01

申请号：US16478864

申请日：2018-01-26

Applicant: Janssen Biotech, Inc.

Inventor： Stuart Emanuel ,  Mark Richter ,  Peter J. Connolly ,  James Patrick Edwards ,  Guangyi Wang ,  Santhosh Kumar Thatikonda ,  Leonid Beigelman ,  Minghong Zhong ,  Gilles Bignan

IPC: A61K31/70 ,  A01N43/04 ,  C07H21/00 ,  A61P31/12 ,  A61P35/00 ,  A61K31/708 ,  A61K31/7084 ,  A61K31/7076

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1C, R1D, B1, R2A, R2B, R2C, R2D, and R2E are defined herein and Formula (II) wherein R1H, R1K, R1J, and R2L are defined herein.

公开(公告)号：US20180162899A1

公开(公告)日：2018-06-14

申请号：US15820592

申请日：2017-11-22

Applicant: Janssen Biotech, Inc.

Inventor： Gilles Bignan ,  Peter Connolly ,  James Patrick Edwards ,  Stuart Emanuel ,  Sylvie Laquerre ,  Tianbao Lu ,  Mark Richter ,  Leonid Beigelman ,  Santhosh Kumar Thatikonda ,  Guangyi Wang ,  Minghong Zhong

IPC: C07H21/02 ,  A61K9/00 ,  A61K9/10 ,  A61P35/00 ,  A61P31/20

Abstract: Disclosed are compounds, compositions and methods for treating viral infections, diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R1A, R1B, R1c, B1, R2A, and R2B are defined herein.