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公开(公告)号：US20150330899A1
公开(公告)日：2015-11-19
申请号：US14710907
申请日：2015-05-13
CPC分类号： G01N21/6428 , B01L3/502707 , B01L2200/16 , B01L2300/0816 , B01L2300/0887 , B05D5/06 , B32B37/18 , B32B37/24 , B32B38/0012 , B32B2037/243 , G01N21/05 , G01N21/6408 , G01N21/645 , G01N21/77 , G01N2021/773 , G01N2021/7786 , Y10T156/1039
摘要： A sensor, system, and method of making a sensor are disclosed. The sensor includes a solid polymer material, and a dopant-containing region of discrete thickness at a surface of the solid polymer. The method of creating the sensor includes impregnating the polymer material with the dopant by contact with a solvent solution containing the dopants. A polymer/solvent gel-layer, whose depth increases with impregnation time, forms after contact of the polymer material in the solvent solution. The dopants are diffused into the polymer material, forming a dopant-containing region of discrete thickness at a surface of the solid polymer.
摘要翻译： 公开了传感器，系统和制造传感器的方法。 传感器包括固体聚合物材料和在固体聚合物的表面处具有离散厚度的掺杂剂区域。 创建传感器的方法包括通过与含有掺杂剂的溶剂溶液接触来浸渍掺杂剂的聚合物材料。 在溶剂溶液中聚合物材料接触后，形成其浸渍时间深度增加的聚合物/溶剂凝胶层。 掺杂剂扩散到聚合物材料中，在固体聚合物的表面形成具有不连续厚度的掺杂剂区域。
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公开(公告)号：US07311926B2
公开(公告)日：2007-12-25
申请号：US10326201
申请日：2002-12-20
申请人： Jay W. Grate , Jungbae Kim
发明人： Jay W. Grate , Jungbae Kim
IPC分类号： A61K9/50
摘要： A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension greater than about 1 μm. One example for making the particle includes modifying the polypeptide molecule to provide α, β-ethylenically unsaturated terminal functional groups, mixing the modified polypeptide molecule with a silicon-containing polymerizable compound, and subjecting the resulting mixture to conditions sufficient for polymerizing the polymerizable compound to form the particle.
摘要翻译： 包含至少一种多肽分子和至少一种与多肽分子共价结合的聚合物的颗粒（和包含多个颗粒的组合物），以形成基本上包含该多肽分子的聚合物壳，其中该颗粒不 定义大于1um的尺寸。 制备该颗粒的一个实例包括修饰多肽分子以提供α，β-烯键式不饱和末端官能团，将修饰的多肽分子与含硅的可聚合化合物混合，并将所得混合物进行足以使可聚合化合物聚合的条件 形成粒子。
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3.发明授权Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components 有权基于柱的分离系统，形成填充柱的方法以及净化样品组分的方法
公开(公告)号：US6136197A
公开(公告)日：2000-10-24
申请号：US318345
申请日：1999-05-25
申请人： Oleg B. Egorov , Matthew J. O'Hara , Jay W. Grate , Darrell P. Chandler , Fred J. Brockman , Cynthia J. Bruckner-Lea
发明人： Oleg B. Egorov , Matthew J. O'Hara , Jay W. Grate , Darrell P. Chandler , Fred J. Brockman , Cynthia J. Bruckner-Lea
CPC分类号： G01N30/58 , B01D15/206 , G01N30/56 , G01N2030/565
摘要： The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.
摘要翻译： 本发明包括用于基于柱的分离的系统，包装和拆包柱的方法以及分离样品组分的方法。 一方面，本发明包括一种包装和拆包柱室的方法，包括：a）在柱室内填充基质材料以形成填充柱; 和b）在包装之后，将基体材料从柱室拆开而不移动柱室。 在另一方面，本发明包括一种用于基于柱的分离的系统，其包括：a）流体通道，所述流体通道包括柱室和与所述塔室流体连通的流动路径，所述流动路径被保持 对载体流体可渗透的材料和悬浮在载体流体中的柱状基质材料不可渗透的流动路径，所述流动路径延伸穿过柱室并通过保持材料，所述流动路径构造成当悬浮液 的流体和柱基材料沿着流动路径流动; 以及b）流体通道延伸穿过柱室和保持材料之间的阀。
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公开(公告)号：US08507606B2
公开(公告)日：2013-08-13
申请号：US11983516
申请日：2007-11-09
申请人： Jay W. Grate , Jungbae Kim
发明人： Jay W. Grate , Jungbae Kim
摘要： A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension greater than about 1 μm. One example for making the particle includes modifying the polypeptide molecule to provide α, β-ethylenically unsaturated terminal functional groups, mixing the modified polypeptide molecule with a silicon-containing polymerizable compound, and subjecting the resulting mixture to conditions sufficient for polymerizing the polymerizable compound to form the particle.
摘要翻译： 包含至少一种多肽分子和至少一种与多肽分子共价结合的聚合物的颗粒（和包含多个颗粒的组合物），以形成基本上包含该多肽分子的聚合物壳，其中该颗粒不 定义大于1um的尺寸。 制备该颗粒的一个实例包括修饰多肽分子以提供α，β-烯键式不饱和末端官能团，将修饰的多肽分子与含硅的可聚合化合物混合，并将所得混合物进行足以使可聚合化合物聚合的条件 形成粒子。
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公开(公告)号：US20110236951A1
公开(公告)日：2011-09-29
申请号：US11983516
申请日：2007-11-09
申请人： Jay W. Grate , Jungbae Kim
发明人： Jay W. Grate , Jungbae Kim
摘要： A particle (and a composition that includes a plurality of the particles) that includes at least one polypeptide molecule and at least one polymer covalently bound to the polypeptide molecule so as to form a polymer shell substantially encompassing the polypeptide molecule, wherein the particle does not define a dimension greater than about 1 μm. One example for making the particle includes modifying the polypeptide molecule to provide α, β-ethylenically unsaturated terminal functional groups, mixing the modified polypeptide molecule with a silicon-containing polymerizable compound, and subjecting the resulting mixture to conditions sufficient for polymerizing the polymerizable compound to form the particle.
摘要翻译： 包含至少一种多肽分子和至少一种与多肽分子共价结合的聚合物的颗粒（和包含多个颗粒的组合物），以形成基本上包含该多肽分子的聚合物壳，其中该颗粒不 限定大于约1μm的尺寸。 制备颗粒的一个实例包括修饰多肽分子以提供α，β-烯键式不饱和末端官能团，将修饰的多肽分子与含硅聚合性化合物混合，并使所得混合物进行足以使可聚合化合物聚合的条件 以形成颗粒。
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公开(公告)号：US07892856B2
公开(公告)日：2011-02-22
申请号：US11646216
申请日：2006-12-26
IPC分类号： G01N33/53
CPC分类号： G01N27/745 , B01J2219/005 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01L3/5027 , B03C1/00 , G01N33/54333 , G01N35/0098 , G01N35/08 , G01N2035/00237 , Y10T436/11 , Y10T436/111666 , Y10T436/112499
摘要： Inventive methods and apparatus are useful for collecting magnetic materials in one or more magnetic fields and resuspending the particles into a dispersion medium, and optionally repeating collection/resuspension one or more times in the same or a different medium, by controlling the direction and rate of fluid flow through a fluid flow path. The methods provide for contacting derivatized particles with test samples and reagents, removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to a wide variety of chemical and biological materials that are susceptible to magnetic labeling, including, for example, cells, viruses, oligonucleotides, proteins, hormones, receptor-ligand complexes, environmental contaminants and the like.
摘要翻译： 本发明的方法和装置可用于在一个或多个磁场中收集磁性材料并将颗粒重新悬浮于分散介质中，并且可选地通过控制相同或不同介质的方向和速率来重复地在相同或不同介质中的收集/再悬浮一次或多次 流体流过流体流动路径。 该方法提供了将衍生化的颗粒与测试样品和试剂接触，除去过量试剂，洗涤磁性材料以及再悬浮以用于分析以及其它用途。 该方法适用于易受磁标记影响的各种化学和生物材料，包括例如细胞，病毒，寡核苷酸，蛋白质，激素，受体 - 配体复合物，环境污染物等。
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公开(公告)号：US07611878B2
公开(公告)日：2009-11-03
申请号：US11251540
申请日：2005-09-30
申请人： Jungbae Kim , Ja Hun Kwak , Jay W. Grate
发明人： Jungbae Kim , Ja Hun Kwak , Jay W. Grate
摘要： The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high biocatalytic activity and stability useful in heterogeneous environment. These new materials provide a new biocatalytic immobilized enzyme system with applications in bioconversion, bioremediation, biosensors, and biofuel cells.
摘要翻译： 本发明一般涉及高稳定性，高活性生物催化材料及其使用方法。 该材料包含具有高异构环境中有用的高生物催化活性和稳定性的酶聚集体涂层。 这些新材料为生物转化，生物修复，生物传感器和生物燃料细胞提供了新的生物催化固定化酶体系。
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8.发明授权公开(公告)号：US06408250B1
公开(公告)日：2002-06-18
申请号：US09372641
申请日：1999-08-10
申请人： Jay W. Grate , Barry M. Wise
发明人： Jay W. Grate , Barry M. Wise
IPC分类号： G01N2900
CPC分类号： G01N33/0031 , G01N29/022 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427 , G01N2291/106
摘要： Disclosed is a method for taking the data generated from an array of responses from a multichannel instrument, and determining the characteristics of a chemical in the sample without the necessity of calibrating or training the instrument with known samples containing the same chemical. The characteristics determined by the method are then used to classify and identify the chemical in the sample. The method can also be used to quantify the concentration of the chemical in the sample.
摘要翻译： 公开了一种用于从多通道仪器的响应阵列产生的数据，以及确定样品中化学物质的特性的方法，而不需要用包含相同化学物质的已知样品校准或训练仪器。 然后使用该方法确定的特性对样品中的化学品进行分类和鉴定。 该方法还可用于量化样品中化学品的浓度。
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公开(公告)号：US6015869A
公开(公告)日：2000-01-18
申请号：US40541
申请日：1998-03-17
申请人： Jay W. Grate , Steven N. Kaganove
发明人： Jay W. Grate , Steven N. Kaganove
摘要： The present invention is a sorbent polymer with the (AB)n sequence where the fluorinated interactive A segment is fluoroalkyl-substituted bisphenol and the oligosiloxane B segment is an oligodimethylsiloxane. More specifically, the fluoroalkyl-substituted bisphenol contains two allyl groups and the oligodimethylsiloxane has terminal Si--H groups. The sorbent polymer may be used as thin films on a variety of chemical sensors, or as a component of a thin film on a chemical sensor. Crosslinked sorbent polymers are processable into stable thin films on sensor devices. Sorbent polymers are also useful in sensor arrays, in surface acoustic wave sensors, and in cladding of optical fibers. Sensor arrays provide better selectivity than single sensors and permit identification and quantification of more than one species in a mixture. The sorbent polymer is synthesized by hydrosilylation polymerization which is achieved by catalyzed heating.
摘要翻译： 本发明是具有（AB）n序列的吸附剂聚合物，其中氟化相互作用A链段是氟烷基取代的双酚，低聚硅氧烷B链段是少聚二甲基硅氧烷。 更具体地，氟代烷基取代的双酚包含两个烯丙基，并且该低聚二甲基硅氧烷具有末端Si-H基团。 吸附剂聚合物可以用作各种化学传感器上的薄膜，或者用作化学传感器上的薄膜的组分。 交联的吸附剂聚合物可加工成传感器设备上的稳定薄膜。 吸收剂聚合物也可用于传感器阵列，表面声波传感器和光纤包层中。 传感器阵列提供比单个传感器更好的选择性，并允许在混合物中识别和定量多于一种物质。 吸附剂聚合物通过氢化硅烷化聚合合成，其通过催化加热实现。
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公开(公告)号：US07611835B2
公开(公告)日：2009-11-03
申请号：US11241506
申请日：2005-09-30
申请人： Jungbae Kim , Ja Hun Kwak , Jay W. Grate
发明人： Jungbae Kim , Ja Hun Kwak , Jay W. Grate
CPC分类号： C12Q1/37 , C12N9/6427 , C12N11/08
摘要： A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and enzyme aggregate providing a material or fiber with high biocatalytic activity and stability useful in heterogeneous environments. In one illustrative approach, enzyme “seeds” are covalently attached to polymer nanofibers followed by treatment with a reagent that crosslinks additional enzyme molecules to the seed enzymes forming enzyme aggregates thereby improving biocatalytic activity due to increased enzyme loading and enzyme stability. This approach creates a useful new biocatalytic immobilized enzyme system with potential applications in bioconversion, bioremediation, biosensors, and biofuel cells.
摘要翻译： 公开了一种制备高稳定性，高活性生物催化材料的方法及其使用方法。 该方法包括用酶和酶聚集物涂覆材料或纤维，提供具有高异构环境中有用的高生物催化活性和稳定性的材料或纤维。 在一个说明性方法中，酶“种子”共价连接到聚合物纳米纤维上，然后用另外的酶分子交联到形成酶聚集体的种子酶的试剂处理，从而由于增加的酶负载和酶稳定性而改善生物催化活性。 这种方法创造了一种有用的新的生物催化固定化酶系统，在生物转化，生物修复，生物传感器和生物燃料电池中具有潜在应用。
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