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18 条记录 (耗时 0.04 秒)

    New heteroarotinoid compounds
    5.
    发明授权
    New heteroarotinoid compounds 失效
    新型类似物类化合物

    公开(公告)号：US4975455A

    公开(公告)日：1990-12-04

    申请号：US336224

    申请日：1989-04-11

    申请人： Jean-Daniel Brion ,  Guillaume Le Baut ,  Patrick Ducrey ,  Sylvie Piessard-Robert ,  Claude Cudennec ,  Genevieve Seurre

    发明人： Jean-Daniel Brion ,  Guillaume Le Baut ,  Patrick Ducrey ,  Sylvie Piessard-Robert ,  Claude Cudennec ,  Genevieve Seurre

    IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P35/00 ,  C07D311/04 ,  C07D311/58

    CPC分类号： C07D311/58

    摘要： Compounds of general formula (I): ##STR1## in which: R denotes a hydrogen atom, a halogen atom or a hydroxy, lower alkyl, lower alkyloxy, carboxyl, (lower alkyloxy)carbonyl, (lower arylalkyloxy)carbonyl, aminocarbonyl, (lower mono- or dialkyl)aminocarbonyl or (lower arylalkyl)aminocarbonyl group, an aminocarbonyl group N-substituted with a heterocyclic radical, or a thio, (lower alkyl)thio, sulfonyl or (lower alkyl)sulfonyl group,R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, denote a hydrogen atom, a halogen atom or a lower alkyl, lower alkenyl, lower alkyloxy or lower alkenyloxy group, optionally substituted with one or more halogen atoms,their isomers, enantiomers, diastereoisomers and also, when R denotes a carboxyl, their addition salts with a pharmaceutically acceptable base and, when R contains a basic group, their addition salts with a pharmaceutically acceptable acid.

    摘要翻译： 通式（I）的化合物：其中：R表示氢原子，卤素原子或羟基，低级烷基，低级烷氧基，羧基，（低级烷氧基）羰基，（低级芳基烷氧基）羰基，氨基羰基，（ 低级单或二烷基）氨基羰基或（低级芳基烷基）氨基羰基，被杂环基取代的氨基羰基，或硫代（低级烷基）硫基，磺酰基或（低级烷基）磺酰基，R1，R2，R3 和可以相同或不同的R 4表示任选被一个或多个卤素原子取代的氢原子，卤素原子或低级烷基，低级链烯基，低级烷氧基或低级链烯氧基，它们的异构体，对映体，非对映异构体，以及 当R表示羧基时，其与药学上可接受的碱的加成盐，当R含有碱性基团时，其与药学上可接受的酸的加成盐。

    Beta-carboline compounds
    7.
    发明授权
    Beta-carboline compounds 失效
    β-咔啉化合物

    公开(公告)号：US06350757B1

    公开(公告)日：2002-02-26

    申请号：US09621742

    申请日：2000-07-21

    申请人： Solo Goldstein ,  Guillaume Poissonnet ,  Jean-Gilles Parmentier ,  Jean-Daniel Brion ,  Mark Millan ,  Anne Dekeyne ,  Jean Boutin

    发明人： Solo Goldstein ,  Guillaume Poissonnet ,  Jean-Gilles Parmentier ,  Jean-Daniel Brion ,  Mark Millan ,  Anne Dekeyne ,  Jean Boutin

    IPC分类号： C07D47114

    CPC分类号： C07D471/04

    摘要： A compound selected from those of formula (I): wherein: represents single or double bond, R1 represents hydrogen, alkyl, —R6-aryl, —R6-cycloalkyl, —R6-heterocycle, —CO2R7—, —COR8, or —CONHR8, wherein R6, R7, and R8 are as defined in the description, R2 represents cyano, mono- or di-alkylaminoalkylaminocarbonyl, —CO2R8, —CONHR8, —NR8R9, —NHCO2R7, or —COR8 wherein R7, R8, and R9 are as defined in the description, R3 and R4 together form (C3-C10)cycloalkyl, R5 represents hydrogen, alkyl, or arylalkyl, Ra, Rb, Rc, Rd, which may be identical or different, represent a group as defined in the description, its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful in the treatment of CNS disorders.

    摘要翻译： 选自式（I）的化合物：其中：CUSTOM-CHARACTER FILE =“US06350757-20020226-P00900.TIF”ID =“CUSTOM-CHARACTER-00001”>表示单键或双键，R1表示氢，烷基， -R6-芳基，-R6-环烷基，-R6-杂环，-CO2R7-，-COR8或-CONHR8，其中R6，R7和R8如说明书中所定义，R 2表示氰基，单或二烷基氨基烷基氨基羰基 ，-CO 2 R 8，-CONHR 8，-NR 8 R 9，-NHCO 2 R 7或-COR 8，其中R 7，R 8和R 9如说明书中所定义，R 3和R 4一起形成（C 3 -C 10）环烷基，R 5表示氢，烷基或芳烷基 可以相同或不同的R a，R b，R c，R d表示本说明书中定义的基团，其异构体及其药学上可接受的酸或碱加成盐，以及含有该基团的药物，其可用于 治疗中枢神经系统疾病。

    TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS.
    9.
    发明申请
    TRIAZABENZO (A)NAPHTHO(2,1,8-CDE) AZULENE COMPOUNDS. 审中-公开
    三氮杂萘（A）萘（2,1,8-CDE）亚苄基化合物。

    公开(公告)号：US20100105666A1

    公开(公告)日：2010-04-29

    申请号：US12448627

    申请日：2008-01-04

    申请人： Jean-Daniel Brion ,  Maud Hervet ,  Anne Moreau ,  Zafiarisoa Dolor Renko ,  Alain Le Ridant ,  Catherine Harpey

    发明人： Jean-Daniel Brion ,  Maud Hervet ,  Anne Moreau ,  Zafiarisoa Dolor Renko ,  Alain Le Ridant ,  Catherine Harpey

    IPC分类号： A61K31/551 ,  C07D487/22 ,  A61P25/22 ,  A61P25/16 ,  A61P25/24

    CPC分类号： C07D471/22

    摘要： Compounds of formula (I): wherein: R1 represents hydrogen, (C1-C6)alkyl, (C1-C6)aminoalkyl or (C1-C6)hydroxyalkyl, R2 represents hydrogen, or R1 and R2, together with the carbon atoms carrying them, form a carbon-carbon bond, R3 represents hydrogen, R4 represents hydrogen, methyl or (C3-C6)alkyl, (C1-C6)aminoalkyl, (C1-C6)hydroxyalkyl, aryl-(C1-C6)alkyl or heterocycloalkyl-(C1-C6)alkyl, or R3 and R4 together with the carbon atoms carrying them, form a carbon-carbon bond, R5, R6, R7 and R8 represent hydrogen, or a pair of geminal substituents (R5 and R6 and/or R7 and R8) form an oxo, thioxo or imino group, R9 represents hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, R10 and R11 represent hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, cyano, nitro, (C1-C6)polyhaloalkyl or optionally substituted amino, n represents an integer between 0 and 4 inclusive, m represents an integer between 0 and 2 inclusive, p represents an integer between 0 and 3 inclusive, X represents a group NR12, R12 represents hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, aryl-(C1-C6)alkyl or (C1-C6)polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

    摘要翻译： 式（I）化合物：其中：R1表示氢，（C1-C6）烷基，（C1-C6）氨基烷基或（C1-C6）羟基烷基，R2表示氢，或R1和R2以及携带它们的碳原子 （C 1 -C 6）烷基，（C 1 -C 6）羟基烷基，芳基 - （C 1 -C 6）烷基或杂环烷基 - （C 1 -C 6） （C1-C6）烷基或R3和R4与携带它们的碳原子一起形成碳 - 碳键，R5，R6，R7和R8表示氢或一对偕取代基（R5和R6和/或R7 卤素，（C1-C6）烷基，（C1-C6）烷氧基，羟基，氰基，硝基，（C1-C6）多卤代烷基或任意取代的氨基，R10 并且R 11表示氢，卤素，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，羟基，氰基，硝基，（C 1 -C 6）多卤代烷基或任选取代的氨基，n表示0至4的整数， 0和2之间的整数，包括0和2， p表示0〜3的整数，X表示NR12，R12表示氢，（C1-C6）烷基，（C2-C6）烯基，芳基 - （C1-C6）烷基或（C1-C6）多卤代烷基， 它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。

    1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds
    10.
    发明申请
    1H-Indole-Pyridinecarboxamide and 1H-Indole-Piperidinecarboxamide Compounds 审中-公开
    1H-吲哚 - 吡啶甲酰胺和1H-吲哚 - 哌啶甲酰胺化合物

    公开(公告)号：US20090258883A1

    公开(公告)日：2009-10-15

    申请号：US11988424

    申请日：2006-07-06

    申请人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

    发明人： Jean-Daniel Brion ,  Fabrice Bintein ,  Rodolphe Razet ,  Patrick Razon ,  Zafiarisoa Dolor Renko ,  Eric Levoirier ,  Jean-Francois Pujol ,  Dinah Weissmann ,  Alain Le Ridant ,  Catherine Harpey

    IPC分类号： A61K31/496 ,  C07D401/12 ,  A61K31/454 ,  A61P25/22 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61K31/4439 ,  C07D401/14

    CPC分类号： C07D401/12

    摘要： Compounds of formula (I): wherein: A represents a divalent radical: wherein: Z represents an oxygen atom or a sulphur atom, R6 represents a hydrogen atom, an alkyl, alkenyl, arylalkyl or polyhaloalkyl group or a substituted, linear or branched alkyl chain, represents a single bond or a double bond, R1, R2, R3 and R4 represent a hydrogen or halogen atom, an alkyl, alkoxy, hydroxy, cyano, nitro, polyhaloalkyl or optionally substituted amino group, or a linear or branched alkyl chain substituted by one or more groups, R5 represents a hydrogen atom or an alkyl, aminoalkyl or hydroxyalkyl group, X and Y represent a hydrogen atom or an alkyl group, Ra, Rb, Rc and Rd represent a hydrogen or halogen atom, an alkyl, hydroxy, alkoxy, cyano, nitro, polyhaloalkyl, optionally substituted amino group, or a substituted, linear or branched alkyl chain, Re represents a hydrogen atom or an alkyl, arylalkyl or alkenyl group or a substituted, linear or branched alkyl chain, their enantiomers, diastereoisomers, and N-oxides, and also addition salts thereof with a pharmaceutically acceptable acid or base.

    摘要翻译： 式（I）化合物：其中：A表示二价基团：其中：Z表示氧原子或硫原子，R6表示氢原子，烷基，烯基，芳基烷基或多卤代烷基或取代的直链或支链烷基 链接，表示单键或双键，R 1，R 2，R 3和R 4表示氢或卤素原子，烷基，烷氧基，羟基，氰基，硝基，多卤代烷基或任选取代的氨基，或直链或支链烷基链 被一个或多个基团取代，R 5表示氢原子或烷基，氨基烷基或羟烷基，X和Y表示氢原子或烷基，R a，R b，R c和R d表示氢或卤素原子，烷基， 羟基，烷氧基，氰基，硝基，多卤代烷基，任选取代的氨基或取代的直链或支链烷基链， 表示氢原子或烷基，芳基烷基或烯基或取代的直链或支链烷基链，它们的对映异构体，非对映异构体和N-氧化物，以及其与药学上可接受的酸或碱的加成盐。