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    Cosmetic composition
    2.
    发明授权
    Cosmetic composition 有权
    化妆品组成

    公开(公告)号：US09012414B2

    公开(公告)日：2015-04-21

    申请号：US13639997

    申请日：2011-04-14

    申请人： Charlotte Simmler ,  Virginie Leplanquais ,  Emmanuelle Noblesse ,  Patrice Andre ,  Annelise Lobstein

    发明人： Charlotte Simmler ,  Virginie Leplanquais ,  Emmanuelle Noblesse ,  Patrice Andre ,  Annelise Lobstein

    IPC分类号： A61K31/7034 ,  A61K8/60 ,  A61K8/49 ,  A61Q19/08 ,  C07H15/203 ,  C07H1/08 ,  C07H15/207

    CPC分类号： A61K8/602 ,  A61K8/498 ,  A61K31/7034 ,  A61Q19/08 ,  C07H1/08 ,  C07H15/203 ,  C07H15/207

    摘要： The invention relates to novel eucomic acid (2-(4-hydroxybenzyl)malic acid) derivatives or plant extracts comprising such derivatives, and also to cosmetic or dermatological compositions containing these compounds or these extracts, and to cosmetic care methods using said compositions. Exemplary compounds are represented by formula (I) below: in which, with the proviso that R1, R2 and R3 are not simultaneously a hydrogen atom, R1 and R3 each independently represent a hydrogen atom or a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain comprising an aromatic group, preferably a phenyl, said aromatic group being preferably substituted with a group comprising a sugar, preferably a monosaccharide or disaccharide, said chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N, and R2 represents a hydrogen atom or a sugar, preferably a monosaccharide or disaccharide, said sugar being optionally substituted, in particular with a residue comprising a saturated or unsaturated, preferably C1-C12, hydrocarbon-based chain itself comprising an aromatic group, preferably a phenyl, said hydrocarbon-based chain optionally also comprising one or more heteroatoms preferably chosen from O, S and N.

    摘要翻译： 本发明涉及包含这些衍生物的新型的泛酸（2-（4-羟基苄基）苹果酸）衍生物或植物提取物，以及含有这些化合物或这些提取物的化妆品或皮肤病学组合物以及使用所述组合物的化妆品护理方法。 示例性化合物由下式（I）表示：其中，条件是R1，R2和R3不同时为氢原子，R1和R3各自独立地表示氢原子或饱和或不饱和的，优选C1-C12， 优选苯基的所述芳族基团优选被包含糖，优选单糖或二糖的基团取代，所述链任选还包含一个或多个优选选自O，S和N的杂原子， 并且R 2表示氢原子或糖，优选单糖或二糖，所述糖任选被取代，特别是与包含饱和或不饱和的，优选C 1 -C 12的基于烃的链本身包含芳族基团的残基，优选为 苯基，所述烃基链任选还包含一个或多个优选选自O，S和N的杂原子。

    METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS
    3.
    发明申请
    METHOD FOR INCREASING THE REPLICATION CAPACITY OF AN INFLUENZA VIRUS IN CULTURED CELLS 审中-公开
    增加培养细胞中流感病毒的复制能力的方法

    公开(公告)号：US20140024101A1

    公开(公告)日：2014-01-23

    申请号：US14110203

    申请日：2012-04-10

    申请人： Vincent Lotteau ,  Benoit De Chassey ,  Patrice Andre ,  Laurene Meyniel-Schicklin ,  Anne Aublin-Gex

    发明人： Vincent Lotteau ,  Benoit De Chassey ,  Patrice Andre ,  Laurene Meyniel-Schicklin ,  Anne Aublin-Gex

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  A61K31/435 ,  C12N2760/16151

    摘要： The present invention relates to methods for increasing the replication capacity of an influenza virus in cultured cells. More particularly, the present invention relates to a method for increasing the replication capacity of an influenza virus in a cell comprising the steps consisting of i) infecting said cell with said influenza virus and ii) culturing said infected cell with a least one molecule selected from the group consisting of Dibucaine, Aprindine, Amiloride, Mevinolin, Simvastatin, Promathazine, Pranlukast, Nimodipine, Ibutilide hemifumarate Salt, Risperidone and derivatives or analogues thereof.

    摘要翻译： 本发明涉及提高培养细胞中流感病毒复制能力的方法。 更具体地说，本发明涉及增加细胞中流感病毒的复制能力的方法，包括以下步骤：i）用所述流感病毒感染所述细胞，和ii）用至少一种选自以下的分子培养所述感染细胞： 包括迪布卡因，奥林定宁，阿米洛利，米维林，辛伐他汀，普拉那嗪，普兰司他，尼莫地平，伊碧替利半富马酸盐，利培酮及其衍生物或类似物。

    Coloring material and its uses, in particular in the field of cosmetics, especially for making up the skin and superficial body growths
    4.
    发明授权
    Coloring material and its uses, in particular in the field of cosmetics, especially for making up the skin and superficial body growths 有权
    着色材料及其用途，特别是在化妆品领域，特别是用于补充皮肤和表面的身体生长

    公开(公告)号：US08216556B2

    公开(公告)日：2012-07-10

    申请号：US12706863

    申请日：2010-02-17

    申请人： Patrice Andre ,  Elodie Verdier ,  Michel Garcia

    发明人： Patrice Andre ,  Elodie Verdier ,  Michel Garcia

    IPC分类号： A61K8/00 ,  A61K8/81

    CPC分类号： C09B61/00 ,  A61K8/25 ,  A61K8/97 ,  A61K2800/43 ,  A61Q1/02 ,  A61Q1/10 ,  A61Q3/02 ,  C09B63/005

    摘要： The invention relates to a solid coloring material obtained by precipitation, in an aqueous medium, of the reaction product of an alkali metal silicate with a colored complex obtained by reaction, in aqueous solution, of a hydrolysable tannin or of a plant extract comprising it with a salt of a metal cation. The invention also relates to a cosmetic composition intended for making up the skin or superficial body growths comprising this coloring material. It also relates to a method for making up the skin or superficial body growths comprising the topical application of this cosmetic composition.

    摘要翻译： 本发明涉及一种固体着色材料，其通过在水性介质中沉淀碱金属硅酸盐与通过在水溶液中将水解性单宁或包含其的植物提取物与 金属阳离子的盐。 本发明还涉及用于构成包含该着色材料的皮肤或表面体生长的化妆品组合物。 它还涉及一种用于构成皮肤或表面体生长的方法，其包括该化妆品组合物的局部应用。

    Use in the cosmetics field of an extract of an exsudate of the plant Daniella oliveri, in particular as an antiwrinkle agent
    5.
    发明授权
    Use in the cosmetics field of an extract of an exsudate of the plant Daniella oliveri, in particular as an antiwrinkle agent 有权
    在化妆品领域中使用植物丹参的渗出物提取物，特别是作为抗皱剂

    公开(公告)号：US07776367B2

    公开(公告)日：2010-08-17

    申请号：US12217230

    申请日：2008-07-02

    申请人： Cécile Lamy ,  Nancy Sauvan ,  Isabelle Renimel ,  Patrice Andre ,  Sylvie Darnault

    发明人： Cécile Lamy ,  Nancy Sauvan ,  Isabelle Renimel ,  Patrice Andre ,  Sylvie Darnault

    IPC分类号： A61K36/00 ,  A61K9/00 ,  A61K47/00

    CPC分类号： A61K8/97 ,  A61Q19/08

    摘要： The invention relates to the use, in a cosmetic composition or for the production of a cosmetic composition, of an extract of an exudate of the plant Daniellia oliveri, said exudate being at least partially made up of the oleoresin of said plant.It relates most particularly to the use of this extract as a cosmetic agent for modifying the surface of the skin by giving it a smoother appearance through a reduction in the depth of the wrinkles and/or fine lines and/or by providing it with a re-plumping effect.It also relates to a cosmetic care method for modifying the surface of the skin by giving it a smoother appearance through a reduction in the depth of the wrinkles and fine lines and/or by providing it with a re-plumping effect, comprising the application, to the areas of the skin in question, of a cosmetic composition containing this extract.

    摘要翻译： 本发明涉及在化妆品组合物中或用于生产化妆品组合物中植物丹参的渗出物提取物的用途，所述渗出物至少部分地由所述植物的油树脂组成。 它最特别地涉及使用这种提取物作为化妆品，以通过减少皱纹和/或细纹的深度和/或通过提供皱纹和/或细纹而使其更平滑的外观来改变皮肤的表面 - 效果。 本发明还涉及一种美容护理方法，其通过减少皱纹和细纹的深度和/或通过使皱纹和细纹的深度赋予其更平滑的外观来改变皮肤的表面， 涉及含有该提取物的化妆品组合物的所述皮肤区域。

    Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro
    7.
    发明申请
    Use of L-alpha-lysophosphatidylcholine to obtain the differentiation of monocytes into mature dendritic cells in vitro 审中-公开
    使用L-α-溶血磷脂酰胆碱在体外获得单核细胞分化成成熟树突状细胞

    公开(公告)号：US20080176820A1

    公开(公告)日：2008-07-24

    申请号：US12076591

    申请日：2008-03-20

    申请人： Vincent Lotteau ,  Patrice Andre

    发明人： Vincent Lotteau ,  Patrice Andre

    IPC分类号： A61K31/685 ,  A61P29/00

    CPC分类号： A61K31/4439 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/24

    摘要： The disclosure relates to a method for in vivo differentiation of monocytes in mature dendritic cells, wherein a) monocytes are provided in an appropriate culture medium, b) the monocycles are differentiated in dendritic cells in the presence of a differentiation factor, c) L-α-lysophosphatidylcholine is added to the medium and mature dendritic cells are obtained. The disclosure also relates to the use of at least one inhibitor of L-α-lysophosphatidylcholine in the production of a medicament for the prevention of an inflammation and/or in order to combat an inflammatory disease and/or autoimmune disease.

    摘要翻译： 本公开涉及成熟树突状细胞中单核细胞的体内分化方法，其中a）在合适的培养基中提供单核细胞，b）在分化因子存在下，单环在树突状细胞中分化，c） 向培养基中加入α-溶血磷脂酰胆碱，得到成熟树突状细胞。 本公开还涉及至少一种L-α-溶血磷脂酰胆碱抑制剂在制备用于预防炎症和/或用于抵抗炎性疾病和/或自身免疫疾病的药物中的用途。

    Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells
    8.
    发明授权
    Use of oxidized lipoproteins for differentiation of precursor cells into mature dendritic cells 失效
    使用氧化脂蛋白将前体细胞分化成成熟树突状细胞

    公开(公告)号：US07259012B2

    公开(公告)日：2007-08-21

    申请号：US10482480

    申请日：2002-07-08

    申请人： Vincent Lotteau ,  Patrice Andre

    发明人： Vincent Lotteau ,  Patrice Andre

    IPC分类号： C12N5/00 ,  C12N5/06 ,  C12N5/08 ,  A61K47/44

    CPC分类号： C12N5/0639 ,  A61K2039/5154 ,  C12N2500/36

    摘要： The invention concerns a method for differentiating precursor cells into mature dendritic cells, comprising placing the precursor cells in a medium suitable for their differentiation and adding to the medium, in a predetermined amount, at least one fraction of oxidized lipoproteins selected among oxidized very low density lipoproteins (VLDLs) and/or oxidized intermediate density lipoproteins (IDLs) and/or oxidized low density lipoproteins (LDLs). The precursor cells are preferably monocytes.

    摘要翻译： 本发明涉及将前体细胞分化为成熟树突状细胞的方法，包括将前体细胞置于适于其分化的培养基中，并以预定量向培养基中加入至少一部分氧化的低密度脂蛋白 脂蛋白（VLDL）和/或氧化的中密度脂蛋白（IDL）和/或氧化的低密度脂蛋白（LDL）。 前体细胞优选为单核细胞。