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公开(公告)号：US4116887A
公开(公告)日：1978-09-26
申请号：US539729
申请日：1975-01-09
申请人： Jean-Marie Lehn , Francois Schue , Sylvia Boileau , Bernd Kaempf , Alain Andre Cau , Jean Robert Moinard , Serge Fernand Raynal
发明人： Jean-Marie Lehn , Francois Schue , Sylvia Boileau , Bernd Kaempf , Alain Andre Cau , Jean Robert Moinard , Serge Fernand Raynal
IPC分类号： C08F4/00 , C08G61/10 , C08G63/82 , C08G63/87 , C08G65/26 , C08G75/00 , C08G75/06 , C08G77/08 , C08G85/00 , C08G65/12 , C08G63/10
CPC分类号： C08G65/2603 , C08F4/00 , C08G61/10 , C08G63/823 , C08G63/87 , C08G65/263 , C08G65/2648 , C08G65/2651 , C08G75/00 , C08G75/06 , C08G77/08 , C08G85/00
摘要： A novel process for polymerization or copolymerization of monomers is described, according to which the reaction is carried out in the presence of an anionic initiator and a macroheterocyclic complexing agent of formula ##STR1## in which: EACH R.sub.1 is a hydrogen atom, a hydrocarbon group or an alkoxycarbonyl group, or the two R.sub.1 together can form a group of the general formula: ##STR2## THAT IS TO SAY FORMING A THIRD BRIDGE BETWEEN THE TWO NITROGEN ATOMS IN THE MOLECULE, A is a hydrocarbon group,D is an oxygen or sulfur atom or a hydrocarbon group, with the proviso that at least two of the groups D are oxygen or sulfur atoms and that, if each R.sub.1 is hydrogen, a hydrocarbon group or an alkoxycarbonyl group, one of these two groups D is oxygen or sulfur and the other is oxygen,n and p are integers ranging from 1 to 3, andm is 2 or 3.
摘要翻译： 描述了单体聚合或共聚的新方法，根据该方法，反应在阴离子引发剂和式（I）的大环杂合络合剂的存在下进行，其中：
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公开(公告)号：US4224429A
公开(公告)日：1980-09-23
申请号：US823590
申请日：1977-08-11
申请人： Jean-Marie Lehn , Francois Schue , Sylvie Boileau , Alain A. Cau , Bernd Kaempf , Jean R. Moinard , Serge F. Raynal
发明人： Jean-Marie Lehn , Francois Schue , Sylvie Boileau , Alain A. Cau , Bernd Kaempf , Jean R. Moinard , Serge F. Raynal
IPC分类号： C08F2/00 , C08F2/04 , C08F4/00 , C08F4/42 , C08F36/00 , C08F36/04 , C08G61/10 , C08G63/00 , C08G63/78 , C08G63/82 , C08G65/26 , C08G77/08 , C08G85/00 , C08F4/46 , C08F4/50 , C08G63/10 , C08G63/62 , C08G65/12
CPC分类号： C08G77/08 , C08F36/04 , C08F4/00 , C08G61/10 , C08G65/2603 , C08G65/2651
摘要： A process for the anionic polymerization or copolymerization of olefinic monomers, dienic monomers, vinyl monomers and heterocyclic monomers is described which comprises reacting at least one monomer which is an olefinic monomer, a vinyl monomer or an heterocyclic monomer with a catalyst capable of inducing anionic polymerization and an aprotic macroheterocyclic cryptant, said at least one monomer being the only medium for the reaction.The macroheterocyclic complexing agent has general formula ##STR1## in which: R.sub.1 is hydrogen, a hydrocarbon radical or alkoxycarbonyl, or the two R.sub.1 together can form a group of the general formula: ##STR2## in which A is a hydrocarbon radical,D is oxygen, sulfur, or a hydrocarbon radical, with the proviso that at leat two of the D groups are oxygen or sulfur and that if R.sub.1 is hydrogen, a hydrocarbon radical or alkoxycarbonyl, one of these two D groups is oxygen or sulfur and the other is oxygen, andn and p are integers from 1 to 3 and m is 2 or 3.
摘要翻译： 描述了烯属单体，二烯单体，乙烯基单体和杂环单体的阴离子聚合或共聚方法，其包括使至少一种单体，即烯属单体，乙烯基单体或杂环单体与能够引发阴离子聚合的催化剂 所述至少一种单体是所述反应的唯一介质。 大环杂合络合剂具有通式“IMAGE”，其中：R 1为氢，烃基或烷氧基羰基，或两个R 1可以形成下列通式的基团：其中A为烃基 ，D是氧，硫或烃基，条件是在两个D基团中的两个是氧或硫，如果R 1是氢，则烃基或烷氧基羰基，这两个D基团之一是氧或硫 另一个为氧，n和p为1〜3的整数，m为2或3。
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3.发明申请公开(公告)号：US20130190524A1
公开(公告)日：2013-07-25
申请号：US13591930
申请日：2012-08-22
申请人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
发明人： Jean-Marie Lehn , Srinivasu Pothukanuri , Alexandros Koumbis , Carolina Duarte , Claude Nicolau
IPC分类号： C07F9/144
CPC分类号： C07F9/144 , C07F9/093 , C07F9/6561 , C07F9/65744 , C07F9/65746
摘要： The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
摘要翻译： 本发明涉及环磷酸的多磷酸化和焦磷酸衍生物。 更具体地说，本发明涉及肌醇的多磷酸化和焦磷酸衍生物。 本发明还涉及肌醇和其它类似的，更亲脂的衍生物的多磷酸化和焦磷酸衍生物的组合物，以及它们作为变构效应器，细胞信号分子类似物和治疗剂的用途。
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公开(公告)号：US20120094961A1
公开(公告)日：2012-04-19
申请号：US13247418
申请日：2011-09-28
申请人： Claude NICOLAU , Jean-Marie Lehn
发明人： Claude NICOLAU , Jean-Marie Lehn
IPC分类号： A61K31/6615 , A61P35/00
CPC分类号： A61K31/6615 , A61K31/665 , C07F9/65746
摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。
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公开(公告)号：US07772003B2
公开(公告)日：2010-08-10
申请号：US10228959
申请日：2002-08-28
CPC分类号： C07J41/0055
摘要： Transfecting compounds which include an aminoglycoside linked to a lipid via a spacer, and their polyguanidylated derivatives are provided. These compounds are useful for the in vitro, ex vivo, or in vivo transfection of nucleic acids into various cell types.
摘要翻译： 提供了包括通过间隔基与脂质连接的氨基糖苷类及其聚胍基化衍生物的化合物。 这些化合物可用于核酸进入各种细胞类型的体外，离体或体内转染。
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6.发明申请CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN 审中-公开硝基磷酸三钙磷酸钙/钠盐作为HEMOGLOBIN的独立效应公开(公告)号：US20100029593A1
公开(公告)日：2010-02-04
申请号：US12554734
申请日：2009-09-04
CPC分类号： A61K31/6615 , A61K31/66 , C07F9/093
摘要： The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
摘要翻译： 本发明涉及三水磷酸肌醇的混合钙/钠盐，其制备方法和使用方法。 混合的钙/钠盐可以是三磷酸肌醇的单钙四钠盐。 使用方法包括以有效量施用上述盐，以治疗由与肺或循环系统功能不足相关的缺氧或其它病症所引起的疾病，例如各种类型的癌症和阿尔茨海默氏病。
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公开(公告)号：US07618954B2
公开(公告)日：2009-11-17
申请号：US11328313
申请日：2006-01-09
IPC分类号： A61K31/663 , C07F9/02
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
摘要翻译： 本发明包括化合物，其组合物和能够将包含内部焦磷酸盐环的改性肌醇六磷酸（IHP）递送至哺乳动物细胞的细胞质的方法。 在某些实施方案中，本发明涉及通过将IHP递送至红细胞的细胞质来增强哺乳动物红细胞传递氧的能力的化合物，其组合物和方法。
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8.发明申请Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation 审中-公开用于治疗以异常细胞增殖为特征的癌症和其他疾病的组合物和方法公开(公告)号：US20080119492A1
公开(公告)日：2008-05-22
申请号：US11374312
申请日：2006-07-28
申请人： Jean-Marie Lehn , Jean-Louis Mergny , Anne Petitjean , Maia-Paule Teulade-Fichou , Andrei Tchirkov , Pierre Verrelle
发明人： Jean-Marie Lehn , Jean-Louis Mergny , Anne Petitjean , Maia-Paule Teulade-Fichou , Andrei Tchirkov , Pierre Verrelle
IPC分类号： A61K31/506 , C07D403/14
CPC分类号： A61K31/506 , C07D401/14
摘要： The present invention relates to compositions and methods for treating cancer and other disease states characterized by abnormal cell proliferation. In particular, the present invention relates to certain novel non-nucleoside pharmacologically active compounds that alter telomere and telomerase functions, regulate cell proliferation and/or treat cancer and other diseases characterized by abnormal cell proliferation. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, and to treat cancer or to inhibit the proliferation of the rumor cells, and to treat other proliferative conditions.
摘要翻译： 本发明涉及用于治疗以异常细胞增殖为特征的癌症和其他疾病状态的组合物和方法。 特别地，本发明涉及改变端粒和端粒酶功能，调节细胞增殖和/或治疗癌症和以异常细胞增殖为特征的其它疾病的某些新型非核苷药物活性化合物。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制端粒酶，调节细胞增殖，以及治疗癌症或抑制肿瘤细胞的增殖 ，并治疗其他增殖性疾病。
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公开(公告)号：US20070141011A1
公开(公告)日：2007-06-21
申请号：US11669560
申请日：2007-01-31
申请人： Jean-Marie Lehn , Andreas Herrmann
发明人： Jean-Marie Lehn , Andreas Herrmann
摘要： The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. The inventive mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include such mixtures.
摘要翻译： 本发明涉及一种动态混合物形式的递送系统，其通过在水存在下使至少一种肼衍生物与至少一种加香，调味剂，驱虫剂或引诱剂，杀菌剂或杀真菌剂醛或酮 。 本发明的混合物能够以受控和延长的方式释放在周围环境中的醛或酮。 此外，本发明还涉及这些动态混合物作为加香成分以及包含这些混合物的加香组合物或香料制品的用途。
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公开(公告)号：US20060116358A1
公开(公告)日：2006-06-01
申请号：US11328313
申请日：2006-01-09
IPC分类号： A61K31/663 , C07F9/02
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/70 , A61K31/715 , A61K35/18 , C07F9/117 , C07F9/65746 , C07H15/207 , C12N5/0641
摘要： The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
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