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公开(公告)号：US20110029084A1
公开(公告)日：2011-02-03
申请号：US12599877
申请日：2008-05-14
IPC分类号： A61F2/44
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are spinal disc implants comprising a foam adapted to completely or partially replace a nucleus pulposus within a spinal disc cavity, the foam being a nonabsorbable, closed cell and having a Poisson ratio of less than 0.5. Also disclosed are methods of implanting a foam, either as an in-situ curable material or as a preformed foam.
摘要翻译： 本文公开了包括适于完全或部分替代脊椎盘腔内的髓核的泡沫的脊椎椎间盘植入物，所述泡沫是不可吸收的闭孔并且泊松比小于0.5。 还公开了将泡沫体作为原位可固化材料或预成型泡沫体进行植入的方法。
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公开(公告)号：US08869802B2
公开(公告)日：2014-10-28
申请号：US13086754
申请日：2011-04-14
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.
摘要翻译： 本文公开了用于治疗脊椎椎间盘核空间缺陷的方法，其包括：（a）通过开放，经皮或腹腔镜技术产生开放以接近核空间中的缺陷; （b）从核空间中去除所需量的组织; （c）将输送导管定位通过所述开口; （d）通过用导管的阻挡部件阻塞开口来流体地隔离核空间; （e）将原位可固化的液体材料通过导管的内腔递送到核空间; 和（f）保持隔离直到液体材料固化。 还公开了用于假体的处理系统和材料。
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公开(公告)号：US20090024107A1
公开(公告)日：2009-01-22
申请号：US12152389
申请日：2008-05-14
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.
摘要翻译： 本文公开了用于治疗脊椎椎间盘核空间缺陷的方法，包括：（a）通过开放，经皮或腹腔镜技术产生开放以接近核空间中的缺陷; （b）从核空间中去除所需量的组织; （c）将输送导管定位通过所述开口; （d）通过用导管的阻挡部件阻塞开口来流体地隔离核空间; （e）将原位可固化的液体材料通过导管的内腔递送到核空间; 和（f）保持隔离直到液体材料固化。 还公开了用于假体的处理系统和材料。
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公开(公告)号：US20110306982A1
公开(公告)日：2011-12-15
申请号：US13086754
申请日：2011-04-14
IPC分类号： A61B17/58
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.
摘要翻译： 本文公开了用于治疗脊椎椎间盘核空间缺陷的方法，包括：（a）通过开放，经皮或腹腔镜技术产生开放以接近核空间中的缺陷; （b）从核空间中去除所需量的组织; （c）将输送导管定位通过所述开口; （d）通过用导管的阻挡部件阻塞开口来流体地隔离核空间; （e）将原位可固化的液体材料通过导管的内腔递送到核空间; 和（f）保持隔离直到液体材料固化。 还公开了用于假体的处理系统和材料。
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公开(公告)号：US20100076486A1
公开(公告)日：2010-03-25
申请号：US12575638
申请日：2009-10-08
IPC分类号： A61B17/03
CPC分类号： A61F2/442 , A61F2002/30069 , A61F2002/30586 , A61F2002/30733 , A61F2002/3092 , A61F2002/444
摘要： Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.
摘要翻译： 本文公开了用于治疗脊椎椎间盘核空间缺陷的方法，其包括：（a）通过开放，经皮或腹腔镜技术产生开放以接近核空间中的缺陷; （b）从核空间中去除所需量的组织; （c）将输送导管定位通过所述开口; （d）通过用导管的阻挡部件阻塞开口来流体地隔离核空间; （e）将原位可固化的液体材料通过导管的内腔递送到核空间; 和（f）保持隔离直到液体材料固化。 还公开了用于假体的处理系统和材料。
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公开(公告)号：US20080221628A1
公开(公告)日：2008-09-11
申请号：US12108063
申请日：2008-04-23
CPC分类号： A61B17/1671 , A61B17/00491 , A61B17/0057 , A61B17/1604 , A61B17/1637 , A61B17/8897 , A61B50/30
摘要： Surgical methods of repairing defects and deficiencies in the spine are disclosed. The methods involve delivering a single part in-situ polymerizing fluid to (i) close a weakened segment or fissure in the annulus fibrosus, (ii) strengthen the annulus, (iii) replace or augment the disc nucleus, or (iv) localize a disc prosthesis. The methods may include placing a delivery conduit adjacent to the repair site and providing a liquid tissue adhesive to bond to and repair a disc defect or deficiency
摘要翻译： 公开了修复脊柱缺陷和缺陷的手术方法。 该方法包括将单一部分原位聚合的流体递送至（i）闭合纤维环中的弱化部分或裂缝，（ii）加强环，（iii）替换或增加椎间盘细胞核，或（iv） 椎间盘假体 所述方法可以包括将输送导管放置在邻近于修复部位并提供液体组织粘合剂以粘合并修复椎间盘缺损或缺陷
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公开(公告)号：US20120179176A1
公开(公告)日：2012-07-12
申请号：US13337393
申请日：2011-12-27
IPC分类号： A61B17/03
CPC分类号： A61L31/10 , A61F2/0063 , A61F2002/009 , A61F2210/0076 , A61F2250/0091 , A61L31/14 , A61L31/16 , C08L71/02
摘要： The present invention relates to a composite prosthesis including a coated mesh having at least one opening through a first surface and a second surface of the coated mesh; the coated mesh comprising a mesh and a biocompatible coating substantially surrounding each filament of the mesh, wherein the biocompatible coating is formed by coating the mesh with a polyol prepolymer and curing the prepolymer, the prepolymer comprising a polyalkylene oxide polyol end capped with isocyanate, the polyalkylene oxide polyol having from about 70% to about 95% ethylene oxide groups and the remainder propylene oxide; and a barrier material comprising a biocompatible membrane constructed and arranged to cover at least one surface of the coated mesh, wherein the barrier material comprises a biologic material.
摘要翻译： 复合假体技术领域本发明涉及一种复合假体，其包括具有穿过第一表面的至少一个开口和涂覆的网的第二表面的涂覆网格; 所述涂覆网包括网和基本上围绕所述网的每个细丝的生物相容性涂层，其中所述生物相容性涂层通过用多元醇预聚物涂覆所述网并固化所述预聚物形成，所述预聚物包含用异氰酸酯封端的聚环氧烷多元醇， 具有约70％至约95％环氧乙烷基团的聚环氧烷多元醇，其余为环氧丙烷; 以及阻挡材料，其包括构造和布置成覆盖所述涂覆网的至少一个表面的生物相容膜，其中所述阻挡材料包括生物材料。
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8.发明申请REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION 有权用于外科修复和补充的可逆性聚氨酯组合物公开(公告)号：US20090012462A1
公开(公告)日：2009-01-08
申请号：US12162039
申请日：2007-01-24
摘要： A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.
摘要翻译： 描述了新的可逆胶凝聚氨酯（RGP）聚合物组合物，以及其制备的新方法及其用于填充组织或膨胀组织中的空间或恢复器官功能的医疗用途。 新型RGP聚合物在静置时形成凝胶，在剪切过程中液化并在剪切后可立即重新形成宏观凝胶。 使用的方法包括将改进的凝胶递送到身体上的部位以填充空隙或增加局部组织体积。
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9.发明授权Reversibly gelling polyurethane composition for surgical repair and augmentation 有权反射胶凝聚氨酯组合物进行手术修复和增强公开(公告)号：US08114157B2
公开(公告)日：2012-02-14
申请号：US12162039
申请日：2007-01-24
IPC分类号： A61F2/00
摘要： A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.
摘要翻译： 描述了新的可逆胶凝聚氨酯（RGP）聚合物组合物，以及其制备的新方法及其用于填充组织或膨胀组织中的空间或恢复器官功能的医疗用途。 新型RGP聚合物在静置时形成凝胶，在剪切过程中液化并在剪切后可立即重新形成宏观凝胶。 使用的方法包括将改进的凝胶递送到身体上的部位以填充空隙或增加局部组织体积。
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公开(公告)号：US10278810B2
公开(公告)日：2019-05-07
申请号：US13096729
申请日：2011-04-28
申请人： Liane Clamen , Paul Glazer , Michael T. Milbocker
发明人： Liane Clamen , Paul Glazer , Michael T. Milbocker
IPC分类号： A61F2/16
摘要： A device and method for forming an adaptive optic in the capsule of a human eye is disclosed, comprising a capsular interface enclosing an optically acceptable medium. The device establishes a physiologic range of optical power in response to a range of ciliary contractile states. The preferred bi-phasic medium of the device is comprised of a solid three dimensional polymeric network suspended in a liquid aqueous phase and bonded to a capsular interface. The polymeric network provides shape to the capsular interface, optical power, and a physiologic response to the suspensory ligament. The three dimensional network of the bi-phasic medium mimics the stacked fiber configuration and elasticity of a natural lens. An alternative embodiment utilizing a single phase medium is also disclosed with associated structural features provided in the capsular interface.
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