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1.发明申请Method for the Production of Polymerized Nanoparticles and Microparticles by Ternary Agent Concentration and Temperature Alteration Induced Immiscibility 审中-公开通过三元试剂浓度和温度改变制备聚合纳米颗粒和微粒的方法诱导不混溶性公开(公告)号：US20090117189A1
公开(公告)日：2009-05-07
申请号：US12351222
申请日：2009-01-09
CPC分类号： C08F2/22 , A61K9/1682 , A61K9/5089
摘要： Polymerized drug delivery devices are described. Additionally, methods are described for producing and for using polymerized particles for use as drug delivery devices.
摘要翻译： 描述了聚合药物递送装置。 另外，描述了用于生产和使用用作药物递送装置的聚合颗粒的方法。
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2.发明授权公开(公告)号：US08377464B2
公开(公告)日：2013-02-19
申请号：US13405604
申请日：2012-02-27
IPC分类号： A61F2/00
CPC分类号： G02B1/043
摘要： This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.
摘要翻译： 本发明描述了可聚合表面活性剂作为共聚单体在形成眼科装置如隐形眼镜，人工晶状体，角膜植入物等中的用途。
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公开(公告)号：US20080142038A1
公开(公告)日：2008-06-19
申请号：US11924336
申请日：2007-10-25
IPC分类号： B08B7/00
摘要： A method for improving the wettability of a medical device is provided, the method comprising the steps of (a) providing a medical device formed from a monomer mixture comprising a hydrophilic monomer and a siloxy-containing monomer, (b) subjecting a surface of the medical device to a surface treatment, and (c) contacting the treated surface of the medical device with a wetting agent solution comprising a carboxylic acid-containing polymer or copolymer to form a carboxylic acid-containing polymeric or copolymeric layer on the treated surface of the medical device.
摘要翻译： 提供一种改善医疗装置的润湿性的方法，所述方法包括以下步骤：（a）提供由包含亲水性单体和含甲硅烷氧基的单体的单体混合物形成的医疗装置，（b）使 医疗装置进行表面处理，以及（c）使处理过的医疗装置的表面与包含含羧酸的聚合物或共聚物的润湿剂溶液接触，以在经处理的表面上形成含羧酸的聚合物或共聚物层 医疗装置。
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4.发明申请公开(公告)号：US20120157565A1
公开(公告)日：2012-06-21
申请号：US13405604
申请日：2012-02-27
IPC分类号： G02B1/04
CPC分类号： G02B1/043
摘要： This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.
摘要翻译： 本发明描述了可聚合表面活性剂作为共聚单体在形成眼科装置如隐形眼镜，人工晶状体，角膜植入物等中的用途。
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5.发明授权公开(公告)号：US08197841B2
公开(公告)日：2012-06-12
申请号：US11020541
申请日：2004-12-22
IPC分类号： A61F2/00
CPC分类号： G02B1/043
摘要： This invention describes the use of polymerizable surfactants as comonomers in forming ophthalmic devices such as contact lenses, intraocular lenses, corneal implants, etc.
摘要翻译： 本发明描述了可聚合表面活性剂作为共聚单体在形成眼科装置如隐形眼镜，人工晶状体，角膜植入物等中的用途。
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6.发明授权Silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups 有权用可聚合的阳离子亲水基团封端的含硅单体公开(公告)号：US07759408B2
公开(公告)日：2010-07-20
申请号：US11341209
申请日：2006-01-27
IPC分类号： G02B1/04 , C08F290/06
CPC分类号： G02B1/043 , A61L27/18 , C08F222/1006 , C08F230/08 , C08F290/06 , C08F290/061 , C08F290/068 , C08G77/388 , C08L51/085 , C08L101/02 , C08L83/04
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymer compositions comprise polymerized silicon-containing monomers end-capped with polymerizable cationic hydrophilic groups.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子单体。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的含有可聚合阳离子亲水基团的含硅单体。
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公开(公告)号：US07622512B2
公开(公告)日：2009-11-24
申请号：US11341208
申请日：2006-01-27
IPC分类号： G02B1/04 , C08F290/06
CPC分类号： C08F230/08 , C08F226/10
摘要： The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. Such properties include the ability to extract the polymerized medical devices with water. This avoids the use of organic solvents as is typical in the art. The polymeric compositions comprise polymerized cationic hydrophilic siloxanyl monomers.
摘要翻译： 本发明涉及可用于制造生物相容性医疗器械的聚合物组合物。 更具体地，本发明涉及能聚合形成具有用于制造眼科装置的理想物理特性的聚合物组合物的某些阳离子单体。 这些性质包括用水提取聚合的医疗装置的能力。 这避免了使用本领域典型的有机溶剂。 聚合物组合物包含聚合的阳离子亲水硅氧烷基单体。
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公开(公告)号：US08100528B2
公开(公告)日：2012-01-24
申请号：US12334619
申请日：2008-12-15
CPC分类号： G02B1/043 , A61L27/34 , A61L31/10 , A61M25/0045 , C08F130/08 , C08F230/00 , C08F293/005 , C08F2438/03 , C08J7/04 , C08J2343/04 , C08J2383/00 , Y10T428/31536 , Y10T428/31663
摘要： This invention is directed toward surface treatment of a device. The surface treatment comprises the attachment of interactive segmented block copolymers to the surface of the substrate by means of interactive functionalities of the segmented block copolymer reacting with complementary surface functionalities in monomeric units along the polymer substrate. The present invention is also directed to a surface modified medical device, examples of which include contact lenses, intraocular lenses, vascular stents, phakic intraocular lenses, aphakic intraocular lenses, corneal implants, catheters, implants, and the like, comprising a surface made by such a method.
摘要翻译： 本发明涉及一种装置的表面处理。 表面处理包括通过与沿着聚合物基底的单体单元的互补表面官能团反应的分段嵌段共聚物的相互作用官能团将相互作用的嵌段共聚物连接到基材的表面。 本发明还涉及一种表面改性医疗装置，其实例包括隐形眼镜，眼内透镜，血管支架，晶状体眼内透镜，无晶状体眼内透镜，角膜植入物，导管，植入物等，其包括由 这样一种方法。
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公开(公告)号：US07919136B2
公开(公告)日：2011-04-05
申请号：US11874427
申请日：2007-11-20
IPC分类号： A61L33/00
CPC分类号： C09D133/02 , A61L27/18 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08J7/047 , C08J2433/00 , G02B1/043 , C08L83/04
摘要： A surface modified biomedical device is provided comprising a biomedical device having a coating on at least a portion thereof, the coating comprising a polymer or copolymer having one or more repeating units of the formula: wherein R independently is a C2-C20 hydrocarbon radical and n is an integer of 2 to 5000.
摘要翻译： 提供了表面改性的生物医学装置，其包括在其至少一部分上具有涂层的生物医学装置，所述涂层包含具有一个或多个下式重复单元的聚合物或共聚物：其中R独立地为C 2 -C 20烃基，n 是2〜5000的整数。
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公开(公告)号：US20090173044A1
公开(公告)日：2009-07-09
申请号：US12258916
申请日：2008-10-27
IPC分类号： B65B55/02
CPC分类号： C11D3/0078 , A45C11/005 , A61L12/04 , B65B25/008 , B65B55/06 , C11D1/82 , C11D17/041 , Y10S514/84
摘要： Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a substantially water-soluble silicone-containing surfactant. Such solutions are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, which may provide significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.
摘要翻译： 公开了用于存储诸如隐形眼镜的眼科装置的包装系统，以及用于包装这些眼科装置的方法以提供穿戴期间镜片的舒适度的解决方案。 包装系统包括存储在包含基本上水溶性的含硅氧烷表面活性剂的水性包装溶液中的眼科装置。 这种溶液长时间保留在未使用的镜片的表面上，导致眼睛中持续存在的表面改性，这可以显着改善首次使用的新鲜隐形眼镜的润湿性能，此外甚至 镜片插入后数小时，防止干燥，提高润滑性。
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