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21 条记录 (耗时 0.026 秒)

    Mer receptor activation by gas6
    1.
    发明授权
    Mer receptor activation by gas6 失效
    气体受体激活受体6

    公开(公告)号：US06169070A

    公开(公告)日：2001-01-02

    申请号：US08628747

    申请日：1996-04-17

    申请人： Jian Chen ,  R. Glenn Hammonds ,  Paul J. Godowski ,  Melanie R. Mark ,  Jennie P. Mather ,  Ronghao Li

    发明人： Jian Chen ,  R. Glenn Hammonds ,  Paul J. Godowski ,  Melanie R. Mark ,  Jennie P. Mather ,  Ronghao Li

    IPC分类号： A61K3818

    CPC分类号： C07K14/745 ,  A61K38/00

    摘要： The translation product of the growth arrest-specific gene 6 (gas6) has been identified as an activator of the Mer receptor protein tyrosine kinase. The invention accordingly provides methods of activating Mer receptor in cells expressing it by exposing them to exogenous gas6 polypeptides. Also provided are methods of enhancing the growth, differentiation, or survival of such cells using gas6 polypeptides.

    摘要翻译： 生长停滞特异性基因6（gas6）的翻译产物已被鉴定为Mer受体蛋白酪氨酸激酶的激活剂。 因此，本发明提供了通过将它们暴露于外源性气体6多肽来激活表达它的细胞中的Mer受体的方法。 还提供了使用gas6多肽增强这些细胞的生长，分化或存活的方法。

    Media for culturing schwann cells
    2.
    发明授权
    Media for culturing schwann cells 失效
    培养雪旺细胞的培养基

    公开(公告)号：US5714385A

    公开(公告)日：1998-02-03

    申请号：US435434

    申请日：1995-05-10

    申请人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    发明人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    IPC分类号： A61K35/12 ,  C12N5/079 ,  C12N5/00

    CPC分类号： C12N5/0622 ,  A61K35/12 ,  C12N2500/90 ,  C12N2501/195 ,  C12N2501/40 ,  C12N2501/998

    摘要： A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.

    摘要翻译： 公开了一种用于增强细胞培养物中雪旺细胞（尤其是人雪旺细胞）的存活和/或增殖的方法，其涉及在包含气体6和其它有丝分裂剂（例如鸟氨酸和毛喉素）的无血清培养基中培养细胞。 培养步骤通常在预孵育期之前，其中包含雪旺细胞的神经组织在合适的条件下培养一段时间以使脱髓鞘发生。 孤立的施旺细胞可用作细胞假体来治疗神经系统损伤的患者。 本发明还提供了用于培养雪旺氏细胞的细胞培养基。

    Isolating and culturing Schwann cells
    3.
    发明授权
    Isolating and culturing Schwann cells 失效
    隔离和培养雪旺氏细胞

    公开(公告)号：US5849585A

    公开(公告)日：1998-12-15

    申请号：US438863

    申请日：1995-05-10

    申请人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    发明人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    IPC分类号： C12N15/00 ,  A61K35/12 ,  A61K35/30 ,  A61P25/00 ,  C12N5/02 ,  C12N5/079 ,  C12N15/09 ,  C12N5/06

    CPC分类号： C12N5/0622 ,  A61K35/30 ,  A61K35/12 ,  C12N2500/90 ,  C12N2501/195 ,  C12N2501/40 ,  C12N2501/998 ,  C12N2533/32 ,  C12N2533/52 ,  C12N2533/54

    摘要： A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.

    摘要翻译： 公开了一种用于增强细胞培养物中雪旺细胞（尤其是人雪旺细胞）的存活和/或增殖的方法，其涉及在包含气体6和其它有丝分裂剂（例如鸟氨酸和毛喉素）的无血清培养基中培养细胞。 培养步骤通常在预孵育期之前，其中包含雪旺细胞的神经组织在合适的条件下培养一段时间以使脱髓鞘发生。 孤立的施旺细胞可用作细胞假体来治疗神经系统损伤的患者。 本发明还提供了用于培养雪旺氏细胞的细胞培养基。

    Isolating and culturing schwann cells
    4.
    发明授权
    Isolating and culturing schwann cells 失效
    隔离和培养施万细胞

    公开(公告)号：US5721139A

    公开(公告)日：1998-02-24

    申请号：US435436

    申请日：1995-05-10

    申请人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    发明人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    IPC分类号： A61K35/12 ,  C12N5/079 ,  C12N5/06

    CPC分类号： C12N5/0622 ,  A61K35/12 ,  C12N2500/90 ,  C12N2501/195 ,  C12N2501/40 ,  C12N2501/998

    摘要： A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.

    摘要翻译： 公开了一种用于增强细胞培养物中雪旺细胞（尤其是人雪旺细胞）的存活和/或增殖的方法，其涉及在包含气体6和其它有丝分裂剂（例如鸟氨酸和毛喉素）的无血清培养基中培养细胞。 培养步骤通常在预孵育期之前，其中包含雪旺细胞的神经组织在合适的条件下培养一段时间以使脱髓鞘发生。 孤立的施旺细胞可用作细胞假体来治疗神经系统损伤的患者。 本发明还提供了用于培养雪旺氏细胞的细胞培养基。

    Method of treating a nervous system injury with cultured schwann cells
    5.
    发明授权
    Method of treating a nervous system injury with cultured schwann cells 失效
    用培养的雪旺细胞治疗神经系统损伤的方法

    公开(公告)号：US6033660A

    公开(公告)日：2000-03-07

    申请号：US438862

    申请日：1995-05-10

    申请人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    发明人： Jennie P. Mather ,  Ronghao Li ,  Jian Chen

    IPC分类号： A61K35/12 ,  C12N5/079 ,  C12N5/06

    CPC分类号： C12N5/0622 ,  A61K35/12 ,  C12N2500/90 ,  C12N2501/195 ,  C12N2501/40 ,  C12N2501/998

    摘要： A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as heregulin and forskolin. The culturing step is generally preceded by a pre-incubation period wherein nerve tissue comprising the Schwann cells is cultured under appropriate conditions and for a period of time such that demyelination occurs. The isolated Schwann cells can be used as cellular prostheses to treat patients with nervous system injuries. The invention also provides a cell culture medium for culturing Schwann cells.

    摘要翻译： 公开了一种用于增强细胞培养物中雪旺细胞（尤其是人雪旺细胞）的存活和/或增殖的方法，其涉及在包含气体6和其它有丝分裂剂（例如鸟氨酸和毛喉素）的无血清培养基中培养细胞。 培养步骤通常在预孵育期之前，其中包含雪旺细胞的神经组织在合适的条件下培养一段时间以使脱髓鞘发生。 孤立的施旺细胞可用作细胞假体来治疗神经系统损伤的患者。 本发明还提供了用于培养雪旺氏细胞的细胞培养基。

    Rse receptor activation
    6.
    发明授权
    Rse receptor activation 失效
    Rse受体激活

    公开(公告)号：US5955420A

    公开(公告)日：1999-09-21

    申请号：US438864

    申请日：1995-05-10

    申请人： Jian Chen ,  R. Glenn Hammonds ,  Paul J. Godowski ,  Melanie R. Mark ,  Jennie P. Mather ,  Ronghao Li

    发明人： Jian Chen ,  R. Glenn Hammonds ,  Paul J. Godowski ,  Melanie R. Mark ,  Jennie P. Mather ,  Ronghao Li

    IPC分类号： A61K38/00 ,  C07K14/745 ,  C12N1/21 ,  C12N15/12 ,  A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/745 ,  A61K38/00

    摘要： An activator of the Rse receptor protein tyrosine kinase has been identified which is encoded by growth arrest-specific gene 6 (gas6). Accordingly, the present invention provides a method of activating the Rse receptor by exposing a cell comprising the Rse receptor to exogenous gas6 polypeptide. Moreover, the present invention is directed to a method for enhancing the survival, proliferation or differentiation of a cell comprising a Rse receptor by exposing the cell to exogenous gas6 polypeptide. The types of cells which can be treated according to the method include glial cells such as Schwann cells.

    摘要翻译： 已经鉴定了由生长停滞特异性基因6（gas6）编码的Rse受体蛋白酪氨酸激酶的激活剂。 因此，本发明提供了通过将包含Rse受体的细胞暴露于外源性气体6多肽来激活Rse受体的方法。 此外，本发明涉及通过将细胞暴露于外源性气体6多肽来增强包含Rse受体的细胞的存活，增殖或分化的方法。 根据该方法可以治疗的细胞类型包括神经胶质细胞，例如施旺细胞。