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公开(公告)号：US06699664B1
公开(公告)日：2004-03-02
申请号：US09667857
申请日：2000-09-20
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed , Thomas S. Vedvick , Darrick Carter
IPC分类号： C12Q168
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/3069 , C07K2317/34 , C07K2319/00
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US07202334B1
公开(公告)日：2007-04-10
申请号：US09636801
申请日：2000-08-10
申请人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
发明人： Jennifer L. Mitcham , Gordon E. King , Paul A. Algate , Steven P. Fling , Marc W. Retter , Gary R. Fanger , Steven G. Reed
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/70532 , C07K2319/00 , Y02A50/472 , Y10S436/813 , Y10S530/806 , Y10S530/828 , Y10S530/853
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US07074898B2
公开(公告)日：2006-07-11
申请号：US10010940
申请日：2001-12-05
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Gary R. Fanger , Marc W. Retter , John A. Stolk , Craig H. Day
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/5156 , A61K2039/53 , C07K14/4748 , C07K14/705 , C07K2319/00 , C12N9/6424 , C12N2760/16022 , C12N2760/16222
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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公开(公告)号：US07048931B1
公开(公告)日：2006-05-23
申请号：US10129909
申请日：2000-11-09
申请人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Marc W. Retter , John A. Stolk , Craig H. Day , Yasir A. W. Skeiky , Aijun Wang
发明人： Jiangchun Xu , Davin C. Dillon , Jennifer L. Mitcham , Susan L. Harlocker , Yuqiu Jiang , Steven G. Reed , Michael D. Kalos , Marc W. Retter , John A. Stolk , Craig H. Day , Yasir A. W. Skeiky , Aijun Wang
CPC分类号： C07K14/4748 , A61K38/00 , C07H21/02 , C07K16/3069 , C07K2317/34 , C07K2317/80
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
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5.发明授权Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer 失效前列腺癌的免疫治疗和免疫诊断的化合物和方法
公开(公告)号：US6034218A
公开(公告)日：2000-03-07
申请号：US946026
申请日：1997-10-07
IPC分类号： A61K39/00 , C07K14/705 , C07K14/82 , C07K14/00
CPC分类号： C07K14/705 , C07K14/82 , A61K39/00
摘要： Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
摘要翻译： 提供了治疗和诊断前列腺癌的化合物和方法。 本发明化合物包括含有至少一部分前列腺蛋白质的多肽。 还提供了包含这样的多肽或编码这种多肽的DNA分子的前列腺癌的免疫治疗用疫苗和药物组合物。 本发明的多肽也可用于产生可用于诊断和监测前列腺癌的抗体。 还提供了用于制备探针，引物和多肽的核酸序列。
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公开(公告)号：US20080226643A1
公开(公告)日：2008-09-18
申请号：US11929833
申请日：2007-10-30
IPC分类号： A61K39/395 , C07H21/04 , C07K9/00 , C07K14/00 , C12N15/64 , C12Q1/68 , C12N5/08 , C07K16/00 , G01N33/53 , C07K19/00 , A61P35/00
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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公开(公告)号：US20080311109A1
公开(公告)日：2008-12-18
申请号：US11929835
申请日：2007-10-30
IPC分类号： A61K35/12 , C07H21/04 , C12N15/63 , C12N5/06 , C07K16/00 , C07K2/00 , G01N33/53 , C12Q1/68 , A61P35/00 , C07K14/00 , C12N5/08 , A61K38/02 , A61K31/711 , A61K39/395 , A61K38/16
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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8.发明申请公开(公告)号：US20110150919A1
公开(公告)日：2011-06-23
申请号：US11929831
申请日：2007-10-30
IPC分类号： A61K39/00 , C07K2/00 , C07H21/04 , A61P35/00 , G01N33/68 , C12N5/0783 , A61K35/12 , A61P37/04
CPC分类号： C07K14/47 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C07K14/4748 , C07K14/82 , C07K16/3015 , C07K2317/21 , C07K2317/34 , C07K2319/00 , C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
摘要翻译： 公开了用于治疗和诊断癌症，特别是乳腺癌的组合物和方法。 示例性组合物包含一种或多种乳腺肿瘤多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是乳腺癌的诊断，预防和/或治疗。
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9.发明授权公开(公告)号：US06861506B1
公开(公告)日：2005-03-01
申请号：US09534825
申请日：2000-03-23
申请人： Tony N. Frudakis , John M. Smith , Steven G. Reed , Lynda E. Misher , Marc W. Retter , Davin C. Dillon
发明人： Tony N. Frudakis , John M. Smith , Steven G. Reed , Lynda E. Misher , Marc W. Retter , Davin C. Dillon
IPC分类号： A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , C07K14/15 , C07K14/47 , C07K14/82 , C12Q1/68 , C07K1/00 , C07K14/00 , C07K17/00 , C07K2/00
CPC分类号： C07K14/005 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/53 , A61K2039/57 , C07K14/47 , C07K14/82 , C07K2319/00 , C12N2740/12022 , C12Q1/6886 , C12Q2600/158
摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.
摘要翻译： 公开了用于乳腺癌检测和治疗的组合物和方法。 所提供的化合物包括优先在乳腺肿瘤组织中表达的核苷酸序列，以及由该核苷酸序列编码的多肽。 还提供包含这些化合物的疫苗和药物组合物，并且可以用于例如乳腺癌的预防和治疗。 多肽也可用于生产抗体，其可用于诊断和监测患者乳腺癌的进展。
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公开(公告)号：US07241876B2
公开(公告)日：2007-07-10
申请号：US09924400
申请日：2001-08-07
申请人： Tony N. Frudakis , Steven G. Reed , John M. Smith , Lynda E. Misher , Davin C. Dillon , Marc W. Retter , Aijun Wang , Yasir A. W. Skeiky , Susan L. Harlocker , Craig H. Day , Samuel X. Li , Ta Deng
发明人： Tony N. Frudakis , Steven G. Reed , John M. Smith , Lynda E. Misher , Davin C. Dillon , Marc W. Retter , Aijun Wang , Yasir A. W. Skeiky , Susan L. Harlocker , Craig H. Day , Samuel X. Li , Ta Deng
IPC分类号： C07H21/02
CPC分类号： C12Q1/6886 , A61K35/12 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/5154 , A61K2039/5156 , A61K2039/53 , A61K2039/57 , C07K14/005 , C07K14/47 , C07K14/82 , C07K2319/00 , C12N2740/14022 , C12Q2600/158
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
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