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1.发明授权Human serum albumin-TIMP2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-TIMP2 fusion protein 有权人血清白蛋白-TMP2融合蛋白，编码其的多核苷酸和产生人血清白蛋白-TMP2融合蛋白的方法公开(公告)号：US07163805B2
公开(公告)日：2007-01-16
申请号：US10888887
申请日：2004-07-08
申请人： Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Ah Kang
发明人： Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Ah Kang
CPC分类号： C07K14/8146 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human serum albumin-TIMP2 fusion protein having the amino acid sequence set forth in SEQ ID NO. 10, a polynucleotide encoding the same and a vector comprising the polynucleotide, a host cell transformed with the vector, a method for producing the human serum albumin-TIMP2 fusion protein and a pharmaceutical composition comprising the human serum albumin-TIMP2 fusion protein. The human serum albumin-TIMP2 fusion protein is stable and retains the activity of TIMP2, thus it can be used as a pharmaceutical composition to treat diseases related to angiogenesis and/or metastasis of cancer cells.
摘要翻译： 本发明提供具有SEQ ID NO：1所示的氨基酸序列的人血清白蛋白-TMP2融合蛋白。 10，编码该多核苷酸的多核苷酸，包含多核苷酸的载体，用该载体转化的宿主细胞，生产人血清白蛋白-TMP2融合蛋白的方法和包含人血清白蛋白-TMP2融合蛋白的药物组合物。 人血清白蛋白TIMP2融合蛋白是稳定的并保留了TIMP2的活性，因此可用作药物组合物来治疗与癌细胞的血管发生和/或转移有关的疾病。
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2.发明申请Human serum albumin-TIMP2 fusion protein, a polynucleotide encoding the same and a method of producing the human serum albumin-TIMP2 fusion protein 有权人血清白蛋白-TMP2融合蛋白，编码其的多核苷酸和产生人血清白蛋白-TMP2融合蛋白的方法公开(公告)号：US20050048627A1
公开(公告)日：2005-03-03
申请号：US10888887
申请日：2004-07-08
申请人： Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Kang
发明人： Jeong-Yoon Kim , Min-Young Kim , Eun-Kyu Park , Jae-Young Chang , Hyun Kang
CPC分类号： C07K14/8146 , A61K38/00 , C07K2319/00
摘要： The present invention provides a human serum albumin-TIMP2 fusion protein having the amino acid sequence set forth in SEQ ID NO. 10, a polynucleotide encoding the same and a vector comprising the polynucleotide, a host cell transformed with the vector, a method for producing the human serum albumin-TIMP2 fusion protein and a pharmaceutical composition comprising the human serum albumin-TIMP2 fusion protein. The human serum albumin-TIMP2 fusion protein is stable and retains the activity of TIMP2, thus it can be used as a pharmaceutical composition to treat diseases related to angiogenesis and/or metastasis of cancer cells.
摘要翻译： 本发明提供具有SEQ ID NO：1所示的氨基酸序列的人血清白蛋白-TMP2融合蛋白。 10，编码该多核苷酸的多核苷酸，包含多核苷酸的载体，用该载体转化的宿主细胞，生产人血清白蛋白-TMP2融合蛋白的方法和包含人血清白蛋白-TMP2融合蛋白的药物组合物。 人血清白蛋白TIMP2融合蛋白是稳定的并保留了TIMP2的活性，因此可用作药物组合物来治疗与癌细胞的血管发生和/或转移有关的疾病。
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3.发明授权YLMPO1 gene derived from yarrowia lipolytica and a process for preparing a glycoprotein not being mannosylphosphorylated by using a mutated yarrowia lipolytica in which YLMPO1 gene is disrupted 有权衍生自解脂耶氏酵母的YLMPO1基因和通过使用其中YLMPO1基因被破坏的突变的解脂耶氏酵母的解脂耶氏酵母制备不被甘露糖基磷酸化的糖蛋白的方法公开(公告)号：US08003349B2
公开(公告)日：2011-08-23
申请号：US12598887
申请日：2007-11-30
申请人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
发明人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
CPC分类号： C12N15/815 , C12N9/1081
摘要： The present invention relates to a novel YlMPO1 gene which plays an important role in mannosylphosphorylation of an industrial yeast Yarrowia lipolytica, and to a method for preparing a host system capable of producing recombinant glycoproteins free of mannosylphosphate by disruption of the gene. The mannosylphosphorylation is suppressed by the disruption of YlMPO1 gene according to the present invention, thereby achieving humanization of glycosylation pathway of Yarrowia lipolytica.
摘要翻译： 本发明涉及一种在工业酵母解脂耶氏酵母（Yarrowia lipolytica）的甘露糖基磷酸化中起重要作用的新型YlMPO1基因，以及能够通过破坏基因产生不含磷酸甘露糖基的重组糖蛋白的宿主系统的方法。 通过根据本发明的YlMPO1基因的破坏来抑制甘露糖基磷酸化，从而实现解脂耶氏酵母的糖基化途径的人源化。
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4.发明申请Novel YLMPO1 Gene Derived From Yarrowia Lipolytica and A Process for Preparing a Glycoprotein Not Being Mannosylphosphorylated By Using a Mutated Yarrowia Lipolytica in Which YLMPO1 Gene is Disrupted 有权来自解脂耶氏酵母的新型YLMPO1基因和通过使用其中YLMPO1基因被破坏的突变型耶氏酵母属（Larrowia Lipolytica）而不是正羰基磷酸化的糖蛋白的制备方法公开(公告)号：US20100227362A1
公开(公告)日：2010-09-09
申请号：US12598887
申请日：2007-11-30
申请人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
发明人： Jeong-Nam Park , Yunkyoung Song , Jeong-Yoon Kim , Doo-Byoung Oh , Hyun Ah Kang
CPC分类号： C12N15/815 , C12N9/1081
摘要： The present invention relates to a novel YlMPOl gene which plays an important role in mannosylphosphorylation of an industrial yeast Yarrowia lipolytica, and to a method for preparing a host system capable of producing recombinant glycoproteins free of mannosylphosphate by disruption of the gene. The mannosylphosphorylation is suppressed by the disruption of YlMPOl gene according to the present invention, thereby achieving humanization of glycosylation pathway of Yarrowia lipolytica.
摘要翻译： 本发明涉及在工业酵母解脂耶氏酵母解脂耶氏酵母的甘油糖基磷酸化中起重要作用的新型YlMPO1基因，以及能够通过破坏基因产生不含磷酸甘露糖基的重组糖蛋白的宿主系统的方法。 通过根据本发明的YlMPO1基因的破坏来抑制甘露糖基磷酸化，从而实现解脂耶氏酵母的糖基化途径的人源化。
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5.发明授权公开(公告)号：US07262287B2
公开(公告)日：2007-08-28
申请号：US10518377
申请日：2003-06-28
申请人： Hyun-Ah Kang , Sang-Ki Rhee , Min-Jeong Sohn , Jeong-Yoon Kim
发明人： Hyun-Ah Kang , Sang-Ki Rhee , Min-Jeong Sohn , Jeong-Yoon Kim
CPC分类号： C12N9/58 , C07K2319/02 , C12N15/815 , C12P21/02 , C12P21/06
摘要： The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYPS gene encoding H. polymorpha yapsin1, a recombinant H. polymorpha strain expressing a foreign protein produced by introducing a gene encoding the foreign protein into the H. polymorpha mutant strain, and a process for preparing a foreign protein comprising culturing the recombinant H. polymorpha strain under conditions to express the foreign protein and isolating the foreign protein from the culture.
摘要翻译： 本发明涉及包含编码多形汉逊酵母多肽1的HpYPS1基因的核酸分子，由核酸分子编码的多肽，通过编码多形汉逊酵母多肽的hpYPS基因的突变而具有降低的yapsin活性的多形汉逊酵母突变菌株， 通过将编码外来蛋白质的基因导入多形汉逊酵母突变菌株而产生的外源蛋白质的重组多形汉逊酵母菌株，以及制备外源蛋白质的方法，包括在表达外源蛋白质的条件下培养重组多形汉逊酵母菌 并从培养物中分离外源蛋白质。
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6.发明申请公开(公告)号：US20050239074A1
公开(公告)日：2005-10-27
申请号：US10518377
申请日：2003-06-28
申请人： Hyun-Ah Kang , Sang-Ki Rhee , Min-Jeong Sohn , Jeong-Yoon Kim
发明人： Hyun-Ah Kang , Sang-Ki Rhee , Min-Jeong Sohn , Jeong-Yoon Kim
IPC分类号： C12N9/58 , C12N15/31 , C12N15/81 , C12P21/02 , C12P21/06 , C12Q1/68 , A61K38/16 , C07H21/04 , C12N1/21 , C12N9/52 , C12N15/09 , C12N15/74
CPC分类号： C12N9/58 , C07K2319/02 , C12N15/815 , C12P21/02 , C12P21/06
摘要： The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYPS gene encoding H. polymorpha yapsin1, a recombinant H. polymorpha strain expressing a foreign protein produced by introducing a gene encoding the foreign protein into the H. polymorpha mutant strain, and a process for preparing a foreign protein comprising culturing the recombinant H. polymorpha strain under conditions to express the foreign protein and isolating the foreign protein from the culture.
摘要翻译： 本发明涉及包含编码多形汉逊酵母多肽1的HpYPS1基因的核酸分子，由核酸分子编码的多肽，通过编码多形汉逊酵母多肽的hpYPS基因的突变而具有降低的yapsin活性的多形汉逊酵母突变菌株， 通过将编码外来蛋白质的基因导入多形汉逊酵母突变菌株而产生的外源蛋白质的重组多形汉逊酵母菌株，以及制备外源蛋白质的方法，包括在表达外源蛋白质的条件下培养重组多形汉逊酵母菌 并从培养物中分离外源蛋白质。
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