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    RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO ESCAPE THE ENDOSOME
    3.
    发明申请
    RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO ESCAPE THE ENDOSOME 有权
    具有增强能力的重组BCG菌株免除内吞

    公开(公告)号：US20080095794A1

    公开(公告)日：2008-04-24

    申请号：US11755936

    申请日：2007-05-31

    申请人： Ronggai Sun ,  David Hone ,  Jerald Sadoff

    发明人： Ronggai Sun ,  David Hone ,  Jerald Sadoff

    IPC分类号： A61K39/00 ,  A61P43/00 ,  C12N1/20

    CPC分类号： A61K39/04 ,  A61K2039/522 ,  A61K2039/523 ,  C07K14/33 ,  Y02A50/412

    摘要： Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomolytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.

    摘要翻译： 提供具有增强的引起MHC-I类限制性CD8 + T细胞免疫应答能力的分枝杆菌菌株。 分枝杆菌菌株被遗传工程化以表达：在中性pH下具有活性的内分解蛋白（例如Perfringolysin O），允许分枝杆菌从内体逃逸到细胞的细胞质中; 和目的抗原，如结核抗原。 本发明还提供含有这样的分枝杆菌菌株的疫苗制剂。

    Vaccine against Gram-negative bacterial infections
    5.
    发明授权
    Vaccine against Gram-negative bacterial infections 失效
    疫苗对革兰氏阴性细菌感染

    公开(公告)号：US07235644B2

    公开(公告)日：2007-06-26

    申请号：US11375215

    申请日：2006-03-15

    申请人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    发明人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    IPC分类号： C07K16/00 ,  A61K39/40 ,  A61K39/395 ,  A61K38/16

    CPC分类号： A61K39/095 ,  A61K39/0258 ,  A61K2039/522 ,  Y02A50/474 ,  Y10S424/803 ,  Y10S530/806 ,  Y10S530/825

    摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

    摘要翻译： 有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及 来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。 相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。 脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

    Multivalent vaccines comprising recombinant viral vectors
    8.
    发明授权
    Multivalent vaccines comprising recombinant viral vectors 有权
    包含重组病毒载体的多价疫苗

    公开(公告)号：US08012467B2

    公开(公告)日：2011-09-06

    申请号：US11667975

    申请日：2005-11-15

    申请人： Menzo J. E. Havenga ,  Ronald Vogels ,  Jerald Sadoff ,  David Hone ,  Yasir A. W. Skeiky ,  Katarina Radosevic

    发明人： Menzo J. E. Havenga ,  Ronald Vogels ,  Jerald Sadoff ,  David Hone ,  Yasir A. W. Skeiky ,  Katarina Radosevic

    IPC分类号： A61K39/00 ,  A61K39/04 ,  A61K39/235 ,  C12N15/31

    CPC分类号： A61K39/04 ,  A61K35/761 ,  A61K2039/523 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55544 ,  C07K14/35 ,  C07K2319/00 ,  C12N2710/10343

    摘要： The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. The invention also relates to the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. The invention furthermore relates to the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.

    摘要翻译： 本发明涉及包含重组载体例如重组腺病毒的疫苗。 载体包含编码来自一种或多种结核分枝杆菌的至少两种抗原的异源核酸。 本发明还涉及连接抗原的特异性蛋白酶识别位点的用途，通过该抗原将经编码的抗原在切割后分离。 在切割后，抗原以单独的方式有助于免疫应答。 重组载体可以包含编码切割接头并分离抗原的蛋白酶的核酸。 本发明还涉及由重组载体编码的遗传佐剂的用途，其中这种遗传佐剂也可以通过存在可切割接头和特异性蛋白酶来切割。

    Vaccine against Gram-negative bacterial infections
    9.
    发明申请
    Vaccine against Gram-negative bacterial infections 失效
    疫苗对革兰氏阴性细菌感染

    公开(公告)号：US20060159702A1

    公开(公告)日：2006-07-20

    申请号：US11375215

    申请日：2006-03-15

    申请人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    发明人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    IPC分类号： A61K39/116

    CPC分类号： A61K39/095 ,  A61K39/0258 ,  A61K2039/522 ,  Y02A50/474 ,  Y10S424/803 ,  Y10S530/806 ,  Y10S530/825

    摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

    摘要翻译： 有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及 来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。 相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。 脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

    Electroporation of mycobacterium and overexpression of antigens in mycobacteria
    10.
    发明申请
    Electroporation of mycobacterium and overexpression of antigens in mycobacteria 有权
    分枝杆菌的电穿孔和抗原在分枝杆菌中的过表达

    公开(公告)号：US20060121054A1

    公开(公告)日：2006-06-08

    申请号：US11288424

    申请日：2005-11-29

    申请人： Ronggai Sun ,  David Hone ,  Jerald Sadoff

    发明人： Ronggai Sun ,  David Hone ,  Jerald Sadoff

    IPC分类号： A61K39/02 ,  A61K39/04 ,  C12N1/21

    CPC分类号： C12N15/74 ,  A61K39/04 ,  A61K2039/523

    摘要： Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains do not display antibiotic resistance, and do not exhibit horizontal transfer to gram-negative bacteria.

    摘要翻译： 提供具有改进疫苗性质的重组分枝杆菌菌株用作疫苗接种剂。 选择重组分枝杆菌菌株的亲本菌株具有有效的免疫原性。 分枝杆菌菌株不显示抗生素抗性，并不表现出向革兰氏阴性细菌的水平转移。