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    HISTONE DEACETYLASE INHIBITORS
    8.
    发明申请
    HISTONE DEACETYLASE INHIBITORS 失效
    HISTONE脱乙酰酶抑制剂

    公开(公告)号：US20070149495A1

    公开(公告)日：2007-06-28

    申请号：US11557402

    申请日：2006-11-07

    申请人： Jerome Bressi ,  Sheldon Cao ,  Jeffrey Stafford ,  Phong Vu

    发明人： Jerome Bressi ,  Sheldon Cao ,  Jeffrey Stafford ,  Phong Vu

    IPC分类号： A61K31/55 ,  A61K31/445 ,  A61K31/401 ,  A61K31/397 ,  A61K31/396 ,  A61K31/395

    CPC分类号： C07C259/06 ,  C07D231/16 ,  C07D239/38 ,  C07D241/44

    摘要： Histone deacetylase inhibitors and uses thereof are provided that have the general formula wherein R1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen; R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl; M is a substituent capable of complexing with a protein metal ion; and L is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.

    摘要翻译： 提供组蛋白脱乙酰酶抑制剂及其用途，其具有以下通式：其中R 1，R 2，R 3和R 4， / SUB>各自独立地选自氢，取代或未取代的直链C 1-12烷基，C 2-12-12氨基烷基或C 1 -C 12烷基， 2-12个氧杂烷基，以及取代和未取代的3,4,5,6,7或8元环，条件是R 3和R 4 不是氢; R 5选自羰基，取代或未取代的C 1-3烷基，取代或未取代的C 1-3烷基， 烷基-C（O），取代或未取代的-C（O）-C 1-3烷基和取代或未取代的-C（O）C（O）C 1-3烷基; M是能与蛋白质金属离子络合的取代基; L是包含连接M取代基与L取代基的α原子的3-12个原子的链的取代基。