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1.发明申请Human Angiostatin Interacting and Tumor Metastasis Involving Protein Variants and Uses Thereof 审中-公开人血管抑素相互作用和肿瘤转移涉及蛋白质变体及其用途公开(公告)号：US20110236389A1
公开(公告)日：2011-09-29
申请号：US12601007
申请日：2007-05-22
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C07H21/04 , C12N1/00 , C07K14/47 , C07K19/00 , C07K16/18 , A61K38/17 , A61P3/10 , A61P35/00 , C07K7/08 , A61P3/04 , A61P3/06 , A61P9/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C07K16/28 , C07K16/30 , C07K2317/34 , C07K2317/73 , C12N9/14
摘要： The invention provides human angiostatin interacting and tumor metastasis involving protein (HAI-TMIP) isoforms, namely HAI-TMIP variants 1 to 7, and human protein complexes comprising HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7. The invention also provides antibodies that immunospecifically bind to HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7 or a complex comprising such a variant, and uses of such antibodies. The present invention provides peptides which may be used as immunogens to distinguish between the HAI-TMIP variants. The invention further provides compounds that modulate the expression and/or activity of HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7, or a complex comprising such a variant, and uses of such compounds in the prevention, treatment and/or management of various disorders, in particular, cancer.
摘要翻译： 本发明提供涉及蛋白质（HAI-TMIP）同种型（即HAI-TMIP变体1至7）的人类血管抑素相互作用和肿瘤转移以及包含HAI-TMIP变体1,2,3,4,5,6或7的人蛋白复合物。 本发明还提供免疫特异性结合HAI-TMIP变体1,2,3,4,5,6或7的抗体或包含这种变体的复合物以及这种抗体的用途。 本发明提供可用作免疫原来区分HAI-TMIP变体的肽。 本发明还提供调节HAI-TMIP变体1,2,3,4,5,6或7的表达和/或活性的化合物或包含这种变体的复合物，以及这些化合物在预防，治疗中的用途 和/或各种疾病的治疗，特别是癌症。
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公开(公告)号：US09015342B2
公开(公告)日：2015-04-21
申请号：US12017534
申请日：2008-01-22
申请人： Jian Ni , Jie Lin , Steven J. Harrington , Naveen Sharma
发明人： Jian Ni , Jie Lin , Steven J. Harrington , Naveen Sharma
IPC分类号： G06F15/173 , H04L12/46 , H04L12/715 , H04L29/08
CPC分类号： H04L12/4625 , H04L45/64 , H04L67/104 , H04L67/1053 , H04L67/1059 , H04L67/1065
摘要： A method and system for designing file replication schemes in file sharing systems consider node storage constraints and node up/down statistics, file storage costs, and file transfer costs among the nodes, user request rates for the files, and user specified file availability requirements. Based on these considerations, a systematic method for designing file replication schemes can be implemented. The method first determines the number of copies of the files to be stored in the system to achieve the desired goal (e.g., to satisfy file availability requirements, or to maximize the system hit rate), and then selects the nodes at which to store the file copies to minimize the total expected cost. The file replication scheme for a peer-to-peer file sharing system in a distributed and adaptive manner can scale to a large number of nodes and files and can handle changes in the user request pattern over time.
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公开(公告)号：US08231873B2
公开(公告)日：2012-07-31
申请号：US12870548
申请日：2010-08-27
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , A61K38/18 , A61K38/19 , A61K38/22 , C07K16/22 , A61P3/10 , A61P19/02 , C07K14/475
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译： 本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。 本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。 还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。
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公开(公告)号：US20120122762A1
公开(公告)日：2012-05-17
申请号：US13359199
申请日：2012-01-26
申请人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
发明人： Steven M. Ruben , Craig A. Rosen , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , D. Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Carrie L. Fischer , Reinhard Ebner , Laurie A. Brewer , Paul A. Moore , Yanggu Shi , David W. LaFleur , Yi Li , Zhizhen Zeng , Hla Kyaw
IPC分类号： A61K38/17 , C12N15/63 , C07K14/435 , C07K16/18 , G01N33/53 , C12Q1/68 , C12P21/00 , G01N33/68 , C12N15/85 , C12N15/70 , C12N1/21 , C12N5/10 , A61P7/00 , A61P35/00 , A61P13/12 , A61P9/00 , A61P11/00 , A61P17/02 , A61P25/00 , A61P5/00 , A61P15/00 , A61P31/00 , A61P1/00 , C12N15/12
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20120039890A9
公开(公告)日：2012-02-16
申请号：US12870548
申请日：2010-08-27
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni
IPC分类号： A61K39/395 , G01N33/53 , A61P37/06 , C07K16/24
CPC分类号： C07K16/24 , A61K38/00 , A61K48/00 , A61K2039/505 , C07H21/04 , C07K14/52 , C07K14/715 , C07K16/2875 , C07K2317/34 , C07K2317/622 , C07K2317/76 , G01N33/564 , G01N33/6863 , G01N2333/52 , G01N2500/00 , G01N2500/02 , G01N2800/245 , Y02A50/473
摘要： The present invention relates to a Neutrokine-alpha antibody and a process for producing a Neutrokine-alpha antibody. The invention further relates to screening methods for identifying compounds that inhibit or enhance the action of Neutrokine-alpha. Also provided are diagnostic methods for detecting autoimmune disorders and therapeutic methods for treating autoimmune disorders using a Neutrokine-alpha antibody.
摘要翻译： 本发明涉及一种Neutrokine-α抗体及其制备Neutrokine-α抗体的方法。 本发明还涉及用于鉴定抑制或增强中枢神经素α作用的化合物的筛选方法。 还提供了用于检测自身免疫疾病的诊断方法和使用中和碱α抗体治疗自身免疫疾病的治疗方法。
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6.发明申请公开(公告)号：US20100261207A9
公开(公告)日：2010-10-14
申请号：US12295572
申请日：2007-03-30
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K16/24 , A61K51/088 , A61K51/1021 , C07K14/525 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域Neutrokine-α和/或Neutrokine-αSV多肽的可溶形式，载体，宿主细胞和重组方法 生产相同。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US07803615B1
公开(公告)日：2010-09-28
申请号：US09042583
申请日：1998-03-17
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Jeffrey Y. Su , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Jeffrey Y. Su , Craig A. Rosen
IPC分类号： C07K14/705 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63
CPC分类号： C07K14/7151 , A61K38/00 , C07K2319/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。 特别地，提供编码人DR5蛋白的分离的核酸分子。 还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。
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8.发明申请公开(公告)号：US20090221008A1
公开(公告)日：2009-09-03
申请号：US12295572
申请日：2007-03-30
申请人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
发明人： Guo-Liang Yu , Reinhard Ebner , Jian Ni , Craig A. Rosen , Stephen Ullrich , Marc Chevrier
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K16/24 , A61K51/088 , A61K51/1021 , C07K14/525 , C07K2317/21 , C07K2317/622 , C07K2317/76
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译： 本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域Neutrokine-α和/或Neutrokine-αSV多肽的可溶形式，载体，宿主细胞和重组方法 生产相同。 本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。 还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20090208969A1
公开(公告)日：2009-08-20
申请号：US12431986
申请日：2009-04-29
申请人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
发明人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
CPC分类号： C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要： Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译： 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。
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公开(公告)号：US20090092608A1
公开(公告)日：2009-04-09
申请号：US12241203
申请日：2008-09-30
申请人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
发明人： Jian Ni , Craig A. Rosen , Reiner L. Gentz
IPC分类号： A61K39/395 , C12N15/11 , C07K14/00 , C07K16/18
CPC分类号： C07K16/2878 , C07K2317/73 , C07K2319/30
摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
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