公开(公告)号：US07085351B2

公开(公告)日：2006-08-01

申请号：US10358160

申请日：2003-02-05

申请人： Jianping Lu ,  Otto Zhou ,  Yuan Cheng

发明人： Jianping Lu ,  Otto Zhou ,  Yuan Cheng

IPC分类号： H01J35/32

CPC分类号： H01J35/06 ,  A61B6/032 ,  A61B6/4021 ,  A61B6/4028 ,  A61B6/405 ,  A61B6/4488 ,  A61B6/482 ,  B82Y10/00 ,  H01J3/021 ,  H01J35/065 ,  H01J35/08 ,  H01J35/105 ,  H01J35/14 ,  H01J35/22 ,  H01J35/28 ,  H01J35/30 ,  H01J2201/30469 ,  H01J2235/06 ,  H01J2235/062 ,  H01J2235/064 ,  H01J2235/068 ,  H05G1/34

摘要： An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.

公开(公告)号：US20070009081A1

公开(公告)日：2007-01-11

申请号：US11441281

申请日：2006-05-25

申请人： Otto Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

发明人： Otto Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

IPC分类号： A61B6/00 ,  G01N23/00 ,  G21K1/12 ,  H05G1/60

CPC分类号： B82Y10/00 ,  A61B6/032 ,  A61B6/4028 ,  A61B6/508 ,  A61B6/541 ,  G01N23/046 ,  G01N2223/316 ,  G01N2223/419 ,  G01N2223/612 ,  H01J35/065 ,  H01J2201/30469 ,  H01J2235/068

摘要： Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode target that emits an x-ray upon impact by the emitted electron, and a collimator. Each electron emitting unit includes an electron field emitting material. The electron field emitting material includes a nanostructured material or a plurality of nanotubes or a plurality of nanowires. Computed tomography methods are also provided.

摘要翻译： 计算机断层摄影装置，包括x射线源和x射线检测单元。 x射线源包括具有多个单独可编程的电子发射单元的阴极，每个单独可编程的电子发射单元在施加电场时发射电子，在被所发射的电子撞击时发射x射线的阳极靶和准直器。 每个电子发射单元包括电子场发射材料。 电子场发射材料包括纳米结构材料或多个纳米管或多个纳米线。 还提供了计算机断层扫描方法。

公开(公告)号：US20060274889A1

公开(公告)日：2006-12-07

申请号：US11415953

申请日：2006-05-02

申请人： Jianping Lu ,  Otto Zhou ,  Yuan Cheng

发明人： Jianping Lu ,  Otto Zhou ,  Yuan Cheng

IPC分类号： H01J35/00

CPC分类号： H01J35/06 ,  A61B6/032 ,  A61B6/4021 ,  A61B6/4028 ,  A61B6/405 ,  A61B6/4488 ,  A61B6/482 ,  B82Y10/00 ,  H01J3/021 ,  H01J35/065 ,  H01J35/08 ,  H01J35/105 ,  H01J35/14 ,  H01J35/22 ,  H01J35/28 ,  H01J35/30 ,  H01J2201/30469 ,  H01J2235/06 ,  H01J2235/062 ,  H01J2235/064 ,  H01J2235/068 ,  H05G1/34

摘要： An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.

摘要翻译： X射线产生装置包括至少部分地由具有至少4A / cm 2的发射电子电流密度的含纳米结构的材料形成的场致发射阴极。 由于容易聚焦冷阴极发射电子并显着降低阳极的加热，因此实现了高能量转换效率和紧凑设计。 此外，通过在阴极和栅极或阳极之间脉冲电场并将电子束聚焦在不同的阳极材料处，可以从单个器件产生具有变化能量的脉冲X射线辐射。 还提供了用于独立控制X射线管中的电子发射电流和X射线能量的方法和装置。 独立控制可以通过调节阴极和阳极之间的距离来实现。 独立控制也可以通过调节阴极的温度来实现。 独立控制也可以通过阴极的光学激发来实现。 阴极可以包括诸如碳纳米管的场发射材料。

公开(公告)号：US20050226361A1

公开(公告)日：2005-10-13

申请号：US11051332

申请日：2005-02-07

申请人： Otto Zhou ,  Yuan Cheng ,  Jian Zhang ,  Yueh Lee ,  Jianping Lu ,  Weili Lin

发明人： Otto Zhou ,  Yuan Cheng ,  Jian Zhang ,  Yueh Lee ,  Jianping Lu ,  Weili Lin

IPC分类号： A61B6/00 ,  A61B6/03 ,  A61B6/14 ,  G01N23/00 ,  G01N23/04 ,  G21K1/12 ,  H01J35/06 ,  H01J35/14 ,  H05G1/60

CPC分类号： A61B6/032 ,  A61B6/4028 ,  A61B6/4488 ,  A61B6/508 ,  A61B6/541 ,  B82Y10/00 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  H01J35/065 ,  H01J35/14

摘要： Computed tomography scanning systems and methods using a field emission x-ray source are disclosed. An exemplary micro-computed tomography scanner comprises a micro-focus field emission x-ray source, an x-ray detector, an object stage placed between the x-ray source and the detector, an electronic control system and a computer that control the x-ray radiation and detector data collection, and computer software that reconstructs the three dimension image of the object using a series of projection images collected from different projection angles. Exemplary methods obtain a computed tomography image of an object in oscillatory motion using the micro computed tomography scanner.

摘要翻译： 公开了使用场致发射X射线源的计算机断层摄影扫描系统和方法。 示例性的微型计算机断层扫描仪包括微焦点场发射x射线源，x射线检测器，放置在x射线源和检测器之间的物体台，控制x射线源的电子控制系统和计算机 射线辐射和检测器数据采集，以及使用从不同投影角度收集的一系列投影图像重建对象的三维图像的计算机软件。 示例性方法使用微型计算机断层摄影扫描仪获得振荡运动中物体的计算机断层摄影图像。

公开(公告)号：US20060008047A1

公开(公告)日：2006-01-12

申请号：US10923385

申请日：2004-08-20

申请人： Otto Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

发明人： Otto Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

IPC分类号： A61B6/00

CPC分类号： B82Y10/00 ,  A61B6/032 ,  A61B6/4028 ,  A61B6/508 ,  A61B6/541 ,  G01N23/046 ,  G01N2223/316 ,  G01N2223/419 ,  G01N2223/612 ,  H01J35/065 ,  H01J2201/30469 ,  H01J2235/068

摘要： Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode target that emits an x-ray upon impact by the emitted electron, and a collimator. Each electron emitting unit includes an electron field emitting material. The electron field emitting material includes a nanostructured material or a plurality of nanotubes or a plurality of nanowires. Computed tomography methods are also provided.

摘要翻译： 计算机断层摄影装置，包括x射线源和x射线检测单元。 x射线源包括具有多个单独可编程的电子发射单元的阴极，每个单独可编程的电子发射单元在施加电场时发射电子，在被发射的电子撞击时发射x射线的阳极靶和准直器。 每个电子发射单元包括电子场发射材料。 电子场发射材料包括纳米结构材料或多个纳米管或多个纳米线。 还提供了计算机断层扫描方法。

公开(公告)号：US08155262B2

公开(公告)日：2012-04-10

申请号：US11526217

申请日：2006-09-22

申请人： Otto Z. Zhou ,  Jianping Lu ,  Jian Zhang ,  Guang Yang ,  Yueh Lee ,  Qi Qiu ,  Yuan Cheng

发明人： Otto Z. Zhou ,  Jianping Lu ,  Jian Zhang ,  Guang Yang ,  Yueh Lee ,  Qi Qiu ,  Yuan Cheng

IPC分类号： A61B6/03

CPC分类号： G01N23/04 ,  G01N2223/204 ,  G01N2223/419

摘要： Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object with a plurality of x-ray beams from a plurality of viewing angles, wherein each x-ray beam has a distinct waveform; detecting the x-ray intensities of the plurality of pulsed x-ray beams as a function of time, and extracting individual projection image data from the detected x-ray intensities based on the distinct waveforms of the x-ray beams for combining the projection image data to generate three-dimensional tomographic image data of the object.

摘要翻译： 公开了用于复用计算机断层摄影的方法，系统和计算机程序产品。 根据一个方面，本文描述的主题可以包括用多个视角对多个X射线束照射物体，其中每个X射线束具有不同的波形; 检测作为时间的函数的多个脉冲X射线束的x射线强度，并且基于用于组合投影图像的x射线束的不同波形从检测到的x射线强度中提取各个投影图像数据 数据以产生对象的三维断层图像数据。

公开(公告)号：US07082182B2

公开(公告)日：2006-07-25

申请号：US10923385

申请日：2004-08-20

申请人： Otto Z. Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

发明人： Otto Z. Zhou ,  Jianping Lu ,  Yueh Lee ,  Weili Lin ,  Yuan Cheng ,  Jian Zhang

IPC分类号： G01N23/00

CPC分类号： B82Y10/00 ,  A61B6/032 ,  A61B6/4028 ,  A61B6/508 ,  A61B6/541 ,  G01N23/046 ,  G01N2223/316 ,  G01N2223/419 ,  G01N2223/612 ,  H01J35/065 ,  H01J2201/30469 ,  H01J2235/068

摘要： Computed tomography device comprising an x-ray source and an x-ray detecting unit. The x-ray source comprises a cathode with a plurality of individually programmable electron emitting units that each emit an electron upon an application of an electric field, an anode target that emits an x-ray upon impact by the emitted electron, and a collimator. Each electron emitting unit includes an electron field emitting material. The electron field emitting material includes a nanostructured material or a plurality of nanotubes or a plurality of nanowires. Computed tomography methods are also provided.

公开(公告)号：US20100239064A1

公开(公告)日：2010-09-23

申请号：US11526217

申请日：2006-09-22

申请人： Otto Z. Zhou ,  Jianping Lu ,  Jian Zhang ,  Guang Yang ,  Yueh Lee ,  Qi Qiu ,  Yuan Cheng

发明人： Otto Z. Zhou ,  Jianping Lu ,  Jian Zhang ,  Guang Yang ,  Yueh Lee ,  Qi Qiu ,  Yuan Cheng

IPC分类号： A61B6/03 ,  G06K9/00

CPC分类号： G01N23/04 ,  G01N2223/204 ,  G01N2223/419

摘要： Methods, systems, and computer program products for multiplexing computed tomography are disclosed. According to one aspect, the subject matter described herein can include illuminating an object with a plurality of x-ray beams from a plurality of viewing angles, wherein each x-ray beam has a distinct waveform; detecting the x-ray intensities of the plurality of pulsed x-ray beams as a function of time, and extracting individual projection image data from the detected x-ray intensities based on the distinct waveforms of the x-ray beams for combining the projection image data to generate three-dimensional tomographic image data of the object.

摘要翻译： 公开了用于复用计算机断层摄影的方法，系统和计算机程序产品。 根据一个方面，本文描述的主题可以包括用多个视角对多个X射线束照射物体，其中每个X射线束具有不同的波形; 检测作为时间的函数的多个脉冲X射线束的x射线强度，并且基于用于组合投影图像的x射线束的不同波形从检测到的x射线强度中提取各个投影图像数据 数据以产生对象的三维断层图像数据。

公开(公告)号：US07227924B2

公开(公告)日：2007-06-05

申请号：US11051332

申请日：2005-02-07

申请人： Otto Z. Zhou ,  Yuan Cheng ,  Jian Zhang ,  Yueh Lee ,  Jianping Lu ,  Weili Lin

发明人： Otto Z. Zhou ,  Yuan Cheng ,  Jian Zhang ,  Yueh Lee ,  Jianping Lu ,  Weili Lin

IPC分类号： G01N23/00

CPC分类号： A61B6/032 ,  A61B6/4028 ,  A61B6/4488 ,  A61B6/508 ,  A61B6/541 ,  B82Y10/00 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612 ,  H01J35/065 ,  H01J35/14

摘要： Computed tomography scanning systems and methods using a field emission x-ray source are disclosed. An exemplary micro-computed tomography scanner comprises a micro-focus field emission x-ray source, an x-ray detector, an object stage placed between the x-ray source and the detector, an electronic control system and a computer that control the x-ray radiation and detector data collection, and computer software that reconstructs the three dimension image of the object using a series of projection images collected from different projection angles. Exemplary methods obtain a computed tomography image of an object in oscillatory motion using the micro computed tomography scanner.

摘要翻译： 公开了使用场致发射X射线源的计算机断层摄影扫描系统和方法。 示例性的微型计算机断层扫描仪包括微焦点场发射x射线源，x射线检测器，放置在x射线源和检测器之间的物体台，控制x射线源的电子控制系统和计算机 射线辐射和检测器数据采集，以及使用从不同投影角度收集的一系列投影图像重建对象的三维图像的计算机软件。 示例性方法使用微型计算机断层摄影扫描仪获得振荡运动中物体的计算机断层摄影图像。

公开(公告)号：US08883782B2

公开(公告)日：2014-11-11

申请号：US13047734

申请日：2011-03-14

申请人： Yuan Cheng ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

发明人： Yuan Cheng ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

IPC分类号： A61K31/42 ,  A61K31/422 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/5377 ,  C07D221/20 ,  C07D235/02 ,  C07D263/08 ,  C07D295/135 ,  C07D491/10 ,  C07D498/10

CPC分类号： C07D491/10 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D221/20 ,  C07D235/02 ,  C07D263/08 ,  C07D295/135 ,  C07D498/10 ,  C07D498/20 ,  C07D513/10 ,  C09B11/28

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

摘要翻译： 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和其它相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I中的A1，A2，A3，A4，A5，A6，R2，R7，X和Y如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。