Glycine transporter-1 inhibitors
    6.
    发明授权
    Glycine transporter-1 inhibitors 有权
    甘氨酸转运蛋白-1抑制剂

    公开(公告)号:US08258306B2

    公开(公告)日:2012-09-04

    申请号:US12746755

    申请日:2008-12-11

    IPC分类号: C07D211/34

    CPC分类号: C07D211/50 C07D241/06

    摘要: The present invention provides compounds that are glycine transporter 1 (hereinafter referred to as GlyT-1) inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of GlyT1 such as cognitive disorders associated with Schizophrenia, ADHD (attention deficit hyperactivity disorder), MCI (mild cognitive impairment), and the like. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

    摘要翻译: 本发明提供了作为甘氨酸转运蛋白1(以下称为GlyT-1)抑制剂的化合物,因此可用于治疗通过抑制GlyT1可治疗的疾病,例如与精神分裂症,ADHD(注意缺陷多动障碍)相关的认知障碍, MCI(轻度认知障碍)等。 还提供含有这些化合物的药物组合物和制备这些化合物的方法。